[PDF][PDF] Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity
…, LG Gonçalves, I Mesquita, C Cunha, A van Laarhoven… - Cell metabolism, 2016 - cell.com
Induction of trained immunity (innate immune memory) is mediated by activation of immune
and metabolic pathways that result in epigenetic rewiring of cellular functional programs. …
and metabolic pathways that result in epigenetic rewiring of cellular functional programs. …
Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells
Cells in homeostasis metabolize glucose mainly through the tricarboxylic acid cycle and
oxidative phosphorylation, while activated cells switch their basal metabolism to aerobic …
oxidative phosphorylation, while activated cells switch their basal metabolism to aerobic …
[HTML][HTML] Plasma levels of danger-associated molecular patterns are associated with immune suppression in trauma patients
…, M van den Berg, A John, A van Laarhoven… - Intensive care …, 2016 - Springer
Purpose Danger-associated molecular patterns (DAMPs) released of trauma could contribute
to an immune suppressed state that renders patients vulnerable towards nosocomial …
to an immune suppressed state that renders patients vulnerable towards nosocomial …
Early Clearance of Mycobacterium tuberculosis Is Associated With Increased Innate Immune Responses
…, L Apriani, A van Laarhoven… - The Journal of …, 2020 - academic.oup.com
Background A proportion of tuberculosis (TB) case contacts do not become infected, even
when heavily exposed. We studied the innate immune responses of TB case contacts to …
when heavily exposed. We studied the innate immune responses of TB case contacts to …
[PDF][PDF] The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity
…, MJ Marakalala, JC Hoving, A Van Laarhoven… - Cell host & …, 2015 - cell.com
The interaction of microbes with pattern recognition receptors (PRRs) is essential for protective
immunity. While many PRRs that recognize mycobacteria have been identified, none is …
immunity. While many PRRs that recognize mycobacteria have been identified, none is …
[HTML][HTML] Diagnosing COVID-19 pneumonia in a pandemic setting: Lung Ultrasound versus CT (LUVCT)–a multicentre, prospective, observational study
…, K Azijli, J Heijmans, A van Laarhoven… - ERJ Open …, 2020 - Eur Respiratory Soc
Background In this coronavirus disease 2019 (COVID-19) pandemic, fast and accurate
testing is needed to profile patients at the emergency department (ED) and efficiently allocate …
testing is needed to profile patients at the emergency department (ED) and efficiently allocate …
[HTML][HTML] Plasma metabolome predicts trained immunity responses after antituberculosis BCG vaccination
…, H Dijkstra, LAB Joosten, A van Laarhoven… - PLoS …, 2022 - journals.plos.org
The antituberculosis vaccine Bacillus Calmette–Guérin (BCG) induces nonspecific protection
against heterologous infections, at least partly through induction of innate immune memory …
against heterologous infections, at least partly through induction of innate immune memory …
Clinical Parameters, Routine Inflammatory Markers, and LTA4H Genotype as Predictors of Mortality Among 608 Patients With Tuberculous Meningitis in Indonesia
A van Laarhoven, S Dian, C Ruesen… - The Journal of …, 2017 - academic.oup.com
Background. Damaging inflammation is thought to contribute to the high morbidity and
mortality of tuberculous meningitis (TBM), but the link between inflammation and outcome …
mortality of tuberculous meningitis (TBM), but the link between inflammation and outcome …
[HTML][HTML] Berberine and obatoclax inhibit SARS-Cov-2 replication in primary human nasal epithelial cells in vitro
…, L Kurver, N van Heerbeek, A van Laarhoven… - Viruses, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged as a new human
pathogen in late 2019 and it has infected over 100 million people in less than a year. There …
pathogen in late 2019 and it has infected over 100 million people in less than a year. There …
[PDF][PDF] Interferon gamma immunotherapy in five critically ill COVID-19 patients with impaired cellular immunity: A case series
A van Laarhoven, L Kurver, GJ Overheul, EJ Kooistra… - Med, 2021 - cell.com
Background Prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
shedding has been described in immunocompromised coronavirus disease 2019 (COVID-19) …
shedding has been described in immunocompromised coronavirus disease 2019 (COVID-19) …