[PDF][PDF] Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity

…, LG Gonçalves, I Mesquita, C Cunha, A van Laarhoven… - Cell metabolism, 2016 - cell.com
Induction of trained immunity (innate immune memory) is mediated by activation of immune
and metabolic pathways that result in epigenetic rewiring of cellular functional programs. …

Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells

…, SC Cheng, V Kumar, A van Laarhoven… - European journal of …, 2016 - Wiley Online Library
Cells in homeostasis metabolize glucose mainly through the tricarboxylic acid cycle and
oxidative phosphorylation, while activated cells switch their basal metabolism to aerobic …

[HTML][HTML] Plasma levels of danger-associated molecular patterns are associated with immune suppression in trauma patients

…, M van den Berg, A John, A van Laarhoven… - Intensive care …, 2016 - Springer
Purpose Danger-associated molecular patterns (DAMPs) released of trauma could contribute
to an immune suppressed state that renders patients vulnerable towards nosocomial …

Early Clearance of Mycobacterium tuberculosis Is Associated With Increased Innate Immune Responses

…, L Apriani, A van Laarhoven… - The Journal of …, 2020 - academic.oup.com
Background A proportion of tuberculosis (TB) case contacts do not become infected, even
when heavily exposed. We studied the innate immune responses of TB case contacts to …

[PDF][PDF] The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity

…, MJ Marakalala, JC Hoving, A Van Laarhoven… - Cell host & …, 2015 - cell.com
The interaction of microbes with pattern recognition receptors (PRRs) is essential for protective
immunity. While many PRRs that recognize mycobacteria have been identified, none is …

[HTML][HTML] Diagnosing COVID-19 pneumonia in a pandemic setting: Lung Ultrasound versus CT (LUVCT)–a multicentre, prospective, observational study

…, K Azijli, J Heijmans, A van Laarhoven… - ERJ Open …, 2020 - Eur Respiratory Soc
Background In this coronavirus disease 2019 (COVID-19) pandemic, fast and accurate
testing is needed to profile patients at the emergency department (ED) and efficiently allocate …

[HTML][HTML] Plasma metabolome predicts trained immunity responses after antituberculosis BCG vaccination

…, H Dijkstra, LAB Joosten, A van Laarhoven… - PLoS …, 2022 - journals.plos.org
The antituberculosis vaccine Bacillus Calmette–Guérin (BCG) induces nonspecific protection
against heterologous infections, at least partly through induction of innate immune memory …

Clinical Parameters, Routine Inflammatory Markers, and LTA4H Genotype as Predictors of Mortality Among 608 Patients With Tuberculous Meningitis in Indonesia

A van Laarhoven, S Dian, C Ruesen… - The Journal of …, 2017 - academic.oup.com
Background. Damaging inflammation is thought to contribute to the high morbidity and
mortality of tuberculous meningitis (TBM), but the link between inflammation and outcome …

[HTML][HTML] Berberine and obatoclax inhibit SARS-Cov-2 replication in primary human nasal epithelial cells in vitro

…, L Kurver, N van Heerbeek, A van Laarhoven… - Viruses, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged as a new human
pathogen in late 2019 and it has infected over 100 million people in less than a year. There …

[PDF][PDF] Interferon gamma immunotherapy in five critically ill COVID-19 patients with impaired cellular immunity: A case series

A van Laarhoven, L Kurver, GJ Overheul, EJ Kooistra… - Med, 2021 - cell.com
Background Prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
shedding has been described in immunocompromised coronavirus disease 2019 (COVID-19) …