Sarcoidosis is a granulomatous disorder of unknown cause, affecting multiple organs, but
mainly the lungs. The exact order of immunological events remains obscure. Reviewing …

… Author links open overlay panel Heleen Vroman , Bernt van den Blink , Mirjam Kool … (B)
Th17 cell differentiation is induced by high antigen dose, CD40 and CD86 expression in addition …

BACKGROUND & AIMS:: We investigated if inhibition of mitogen-activated protein kinases (MAPKs)
was beneficial in Crohn's disease. METHODS:: Inhibition of JNK and p38 MAPK …

Importance Tissue verification of noncaseating granulomas is recommended for the diagnosis
of sarcoidosis. Bronchoscopy with transbronchial lung biopsies, the current diagnostic …

… Bernt van den Blink; Bernt van den Blink … Tests for HIV and hepatitis B and C were
negative. The participants did not use any medication. All participants were nonsmokers. …

… Bernt van den Blink … (A and B) Representative sample is shown for blood (A) and BAL cells
(B) from a patient with sarcoidosis. Lymphocytes were analyzed using the following series of …

… b Patients receiving a stable dosage of pirfenidone or nintedanib. … van den Blink B, Dillingh
… with patients treated with placebo (Figure 2B). Additional analyses showing the distribution in …

… Bernt van den Blink , Bernt van den Blink … 1B). We did not detect differences between
patients and healthy controls for the other two Th17 cytokines tested, IL-17F and IL-22 (Fig. 1…

… Dr Van Den Blink reported being formerly employed by and receiving warrants (subscription
rights) from Galapagos NV. Dr Fieuw reported being employed by and receiving warrants (…

Within the group of Idiopathic Interstitial Pneumonias (IIPs), above all Idiopathic Pulmonary
Fibrosis (IPF) poses a considerable diagnostic and therapeutic problem. Although genetic …