Mutations in CCNO result in congenital mucociliary clearance disorder with reduced generation of multiple motile cilia
…, T Zimmermann, C Koerner-Rettberg… - Nature …, 2014 - nature.com
Using a whole-exome sequencing strategy, we identified recessive CCNO (encoding cyclin
O) mutations in 16 individuals suffering from chronic destructive lung disease due to …
O) mutations in 16 individuals suffering from chronic destructive lung disease due to …
[PDF][PDF] ZMYND10 is mutated in primary ciliary dyskinesia and interacts with LRRC6
…, S Levy, S Fan, C Koerner-Rettberg… - The American Journal of …, 2013 - cell.com
Defects of motile cilia cause primary ciliary dyskinesia (PCD), characterized by recurrent
respiratory infections and male infertility. Using whole-exome resequencing and high-…
respiratory infections and male infertility. Using whole-exome resequencing and high-…
Preventive inhalation of hypertonic saline in infants with cystic fibrosis (PRESIS). A randomized, double-blind, controlled study
…, J Hüsing, C Koerner-Rettberg… - American journal of …, 2019 - atsjournals.org
Rationale: Cystic fibrosis (CF) lung disease starts in early infancy, suggesting that preventive
treatment may be most beneficial. Lung clearance index (LCI) and chest magnetic …
treatment may be most beneficial. Lung clearance index (LCI) and chest magnetic …
Sustained increases in numbers of pulmonary dendritic cells after respiratory syncytial virus infection
…, H Bartz, K Hörner, S Doths, C Koerner-Rettberg… - Journal of Allergy and …, 2004 - Elsevier
BACKGROUND: Respiratory syncytial virus (RSV) bronchiolitis in infants can lead to
wheezing and early allergic sensitization. In mice, RSV infection enhances allergic airway …
wheezing and early allergic sensitization. In mice, RSV infection enhances allergic airway …
Lung function in patients with primary ciliary dyskinesia: an iPCD Cohort study
…, B Karadag, C Koerner-Rettberg… - European respiratory …, 2018 - Eur Respiratory Soc
Primary ciliary dyskinesia (PCD) has been considered a relatively mild disease, especially
compared to cystic fibrosis (CF), but studies on lung function in PCD patients have been few …
compared to cystic fibrosis (CF), but studies on lung function in PCD patients have been few …
The international primary ciliary dyskinesia cohort (iPCD Cohort): methods and first results
…, B Karadag, C Koerner-Rettberg… - European respiratory …, 2017 - Eur Respiratory Soc
Data on primary ciliary dyskinesia (PCD) epidemiology is scarce and published studies are
characterised by low numbers. In the framework of the European Union project BESTCILIA …
characterised by low numbers. In the framework of the European Union project BESTCILIA …
[HTML][HTML] Factors Associated with Worse Lung Function in Cystic Fibrosis Patients with Persistent Staphylococcus aureus
…, P Küster, M Ballmann, C Koerner-Rettberg… - PloS one, 2016 - journals.plos.org
Background Staphylococcus aureus is an important pathogen in cystic fibrosis (CF).
However, it is not clear which factors are associated with worse lung function in patients with …
However, it is not clear which factors are associated with worse lung function in patients with …
Long-term safety and efficacy of tezacaftor–ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del …
…, J Mainz, A Kiefer, C Koerner-Rettberg… - The Lancet …, 2021 - thelancet.com
Background Tezacaftor–ivacaftor is an approved cystic fibrosis transmembrane conductance
regulator (CFTR) modulator shown to be efficacious and generally safe and well tolerated …
regulator (CFTR) modulator shown to be efficacious and generally safe and well tolerated …
[HTML][HTML] High variability in oral glucose tolerance among 1,128 patients with cystic fibrosis: a multicenter screening study
…, JM Hermann, S Junge, C Koerner-Rettberg… - PLoS …, 2014 - journals.plos.org
Background In cystic fibrosis, highly variable glucose tolerance is suspected. However, no
study provided within-patient coefficients of variation. The main objective of this short report …
study provided within-patient coefficients of variation. The main objective of this short report …
[HTML][HTML] Randomized controlled phase 2 trial of hydroxychloroquine in childhood interstitial lung disease
…, J Schulze, W Baden, C Koerner-Rettberg… - Orphanet Journal of …, 2022 - Springer
Background No results of controlled trials are available for any of the few treatments offered
to children with interstitial lung diseases (chILD). We evaluated hydroxychloroquine (HCQ) …
to children with interstitial lung diseases (chILD). We evaluated hydroxychloroquine (HCQ) …