Prevalence, risk factors, and clinical implications of preserved ratio impaired spirometry: a UK Biobank cohort analysis
DH Higbee, R Granell, GD Smith… - The Lancet Respiratory …, 2022 - thelancet.com
Background Preserved ratio impaired spirometry (PRISm) is defined as a FEV 1 of less than
80% predicted and a FEV 1 /forced vital capacity (FVC) ratio of 0·70 or higher. Previous …
80% predicted and a FEV 1 /forced vital capacity (FVC) ratio of 0·70 or higher. Previous …
[HTML][HTML] Lack of correlation between the spatial distribution of A2E and lipofuscin fluorescence in the human retinal pigment epithelium
Z Ablonczy, D Higbee, DM Anderson… - … & visual science, 2013 - tvst.arvojournals.org
Purpose.: The accumulation of lipofuscin in the RPE is a hallmark of aging in the eye. The
best characterized component of lipofuscin is A2E, a bis-retinoid byproduct of the normal …
best characterized component of lipofuscin is A2E, a bis-retinoid byproduct of the normal …
[HTML][HTML] Lipofuscin and N-retinylidene-N-retinylethanolamine (A2E) accumulate in retinal pigment epithelium in absence of light exposure: their origin is 11-cis-retinal
NP Boyer, D Higbee, MB Currin, LR Blakeley… - Journal of Biological …, 2012 - ASBMB
The age-dependent accumulation of lipofuscin in the retinal pigment epithelium (RPE) has
been associated with the development of retinal diseases, particularly age-related macular …
been associated with the development of retinal diseases, particularly age-related macular …
Lung function and cardiovascular disease: a two-sample Mendelian randomisation study
DH Higbee, R Granell, E Sanderson… - European …, 2021 - Eur Respiratory Soc
Background Observational studies suggest an association between reduced lung function
and risk of coronary artery disease and ischaemic stroke, independent of shared …
and risk of coronary artery disease and ischaemic stroke, independent of shared …
The impact of asthma on mental health and wellbeing during COVID-19 lockdown
DH Higbee, GW Nava, ASF Kwong… - European …, 2021 - Eur Respiratory Soc
It has been assumed that people with asthma would be at a high risk of developing severe
illness from coronavirus disease 2019 (COVID-19), despite a lack of evidence [1]. Social …
illness from coronavirus disease 2019 (COVID-19), despite a lack of evidence [1]. Social …
[HTML][HTML] The impact of the first COVID-19 surge on severe asthma patients in the UK. Which is worse: the virus or the lockdown?
…, MG Crooks, A Thompson, D Higbee… - ERJ open …, 2021 - Eur Respiratory Soc
Respiratory viral infections are a significant cause of morbidity in asthma [1]. Patients with
severe asthma were assumed to be at greater risk from novel coronavirus disease 2019 (…
severe asthma were assumed to be at greater risk from novel coronavirus disease 2019 (…
Similar molecules spatially correlate with lipofuscin and N-retinylidene-N-retinylethanolamine in the mouse but not in the human retinal pigment epithelium
Z Ablonczy, D Higbee, AC Grey, Y Koutalos… - Archives of biochemistry …, 2013 - Elsevier
The accumulation of lipofuscin in the retinal pigment epithelium (RPE) has been implicated
in the development of age-related macular degeneration (AMD) in humans. The exact …
in the development of age-related macular degeneration (AMD) in humans. The exact …
[HTML][HTML] Cognitive impairment in COPD: an often overlooked co-morbidity
DH Higbee, JW Dodd - Expert review of respiratory medicine, 2021 - Taylor & Francis
Chronic Obstructive Pulmonary Disease (COPD) is characterized by multiple co-morbidities,
such as cardiovascular disease, diabetes, depression, and osteoporosis [1]. However, co-…
such as cardiovascular disease, diabetes, depression, and osteoporosis [1]. However, co-…
[HTML][HTML] Lung function, COPD and cognitive function: a multivariable and two sample Mendelian randomization study
Background Observational studies show an association between reduced lung function and
impaired cognition. Cognitive dysfunction influences important health outcomes and is a …
impaired cognition. Cognitive dysfunction influences important health outcomes and is a …
Miniaturization of electrospray ionization mass spectrometry
…, PM Bigwarfe Jr, TP White, DR Smith, DJ Higbee - 2003 - Taylor & Francis
1. Abstract The development of electrospray ionization (ESI) has proved an enormous
breakthrough in structural biology because it provides a means for transferring large biological …
breakthrough in structural biology because it provides a means for transferring large biological …