Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced
increased sebum production, altered keratinisation, inflammation, and bacterial …

Atopic dermatitis (AD) is a chronic, pruritic, inflammatory dermatosis that affects up to 25% of
children and 2% to 3% of adults. This guideline addresses important clinical questions that …

Abstract Knowledge of the complete genomic DNA sequence of an organism allows a systematic
approach to defining its genetic components. The genomic sequence provides access …

Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by
hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80% 1 , 2 . …

… In this article, HP Williams explains his original motivation and objectives in writing the book,
how it has been modified and updated over the years, what is new in this edition and why it …

Importance Cancer is among the leading causes of death worldwide. Current estimates of
cancer burden in individual countries and regions are necessary to inform local cancer control …

Background The incidence and severity of herpes zoster and postherpetic neuralgia increase
with age in association with a progressive decline in cell-mediated immunity to varicella–…

Background Glucosamine and chondroitin sulfate are used to treat osteoarthritis. The
multicenter, double-blind, placebo- and celecoxib-controlled Glucosamine/chondroitin Arthritis …

Background Data for trends in prevalence of asthma, allergic rhinoconjunctivitis, and eczema
over time are scarce. We repeated the International Study of Asthma and Allergies in …