A fundamental function of the brain is to evaluate the emotional and motivational significance
of stimuli and to adapt behaviour accordingly. The IMAGEN study is the first multicentre …

There is recognition that biomedical research into the causes of mental disorders and their
treatment needs to adopt new approaches to research. Novel biomedical techniques have …

Neuroimaging studies have consistently shown functional brain abnormalities in patients
with Bipolar Disorder (BD) and Major Depressive Disorder (MDD). However, the extent to …

During rest, brain activity is synchronized between different regions widely distributed throughout
the brain, forming functional networks. However, the molecular mechanisms supporting …

The resting-state cerebral metabolic rates for glucose of 10 severely depressed patients (seven
bipolar and three unipolar) were compared, before and after treatment with tricyclic …

A comprehensive account of the causes of alcohol misuse must accommodate individual
differences in biology, psychology and environment, and must disentangle cause and effect. …

Nebulized budesonide has been used successfully to treat acute asthma exacerbation, and
we hypothesized that it could also be effective for exacerbations of chronic obstructive …

The impulsive behavior that is often characteristic of adolescence may reflect underlying
neurodevelopmental processes. Moreover, impulsivity is a multi-dimensional construct, and it is …

The extent of structural brain damage and related cognitive deficits has been little described
in alcohol-dependent individuals with preserved social functioning. Thus, we investigated …

The authors compared 16 nondepressed obsessive‐compulsive patients (OCS) with 8 normal
controls (NC) of similar age for resting‐state regional cerebral glucose metabolic rates (…