Background Advances in our knowledge of attachment, stress and coping may foster new
explanations for the development of challenging behaviour in people with intellectual disability …

Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder that manifests as pulmonary
emphysema, liver cirrhosis and, rarely, as the skin disease panniculitis, and is characterized by …

α 1 -antitrypsin deficiency (AATD) is the most common hereditary disorder in adults. It is
associated with an increased risk of developing pulmonary emphysema and liver disease. The …

Phagocytes are able to generate reactive oxygen species by an activatable NADPH
oxidase system. We investigated the inhibition of NADPH oxidase activation by a methoxy-…

We demonstrate that four different proteins from calf thymus are able to restore splicing in
the same splicing-deficient extract using several different pre-mRNA substrates. These …

We have investigated whether restoration of the balance between neutrophil elastase and its
inhibitor, α 1 -antitrypsin, can prevent the progression of pulmonary emphysema in patients …

We have identified human prostate cancer- and tissue-specific genes using cDNA library
subtraction in conjunction with high throughput microarray screening. Subtracted cDNA …

Antileukoprotease (ALP), or secretory leukocyte proteinase inhibitor, is an endogenous
inhibitor of serine proteinases that is present in various external secretions. ALP, one of the …

Cigarette smoking results in oxidative stress and inflammation in the lungs, which are
involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). 4-Hydroxy-2-…

Chronic obstructive pulmonary disease (COPD) is one of the most common causes of death,
with cigarette smoking among the main risk factors. Hallmarks of COPD include chronic …