Background Respiratory syncytial virus (RSV) is the most common cause of acute lower
respiratory infection in young children. We previously estimated that in 2015, 33·1 million …

Chronic obstructive pulmonary disease is mainly a smoking-related disorder and affects
millions of people worldwide, with a large effect on individual patients and society as a whole. …

Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung
cell types in health and disease is currently revolutionizing the identification of disease …

There is pressing urgency to understand the pathogenesis of the severe acute respiratory
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-…

Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions. …

Human lungs enable efficient gas exchange and form an interface with the environment, which
depends on mucosal immunity for protection against infectious agents. Tightly controlled …

Background Respiratory syncytial virus (RSV) is a major cause of hospitalisation in infants.
The burden of RSV infection in healthy term infants has not yet been established. Accurate …

Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …

Genome-wide association studies (GWAS) have identified loci reproducibly associated with
pulmonary diseases; however, the molecular mechanism underlying these associations are …

Oscillometry (also known as the forced oscillation technique) measures the mechanical
properties of the respiratory system (upper and intrathoracic airways, lung tissue and chest wall) …