Asthma can be considered a combination of three features: airways obstruction with spontaneous
and pharmacologic reversibility, increased airways responsiveness to exogenous and …

Airway inflammation is central to the pathogenesis of both airway remodelling and
parenchymal destruction in chronic obstructive pulmonary disease (COPD). Neutrophils, …

Since the first attempts to use standardised methods for sampling induced airways sputum,
two methods for processing the expectorate have evolved. The first involves selecting all …

Severe or therapy-resistant asthma is increasingly recognised as a major unmet need. A
Task Force, supported by the European Respiratory Society and American Thoracic Society, …

… R. Djukanovic was supported by a TV James fellowship awarded by the British Medical
Association. The cell line 52B83 was supplied to Celltech by Dr. Wim Buurman (Biomedical …

Background Interleukin-5 (IL-5) is essential for the formation of eosinophils, which are thought
to have a major role in the pathogenesis of asthma and other allergic diseases. We aimed …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection carries
a substantial risk of severe and prolonged illness; treatment options are currently limited. …

Materials and Methods Subjects The details of the subjects are shown in Table 1. There
were all nonsmokers, and the asthmatics used only inhaled medication. Five days prior to …

… There was also a weak, but significant, positive correlation between the concentrations of
albumin and those of tryptase (r s = 0.42, p = 0.001) and ECP (r s = 0.36, p < 0.01). …

As physiologic and autopsy evidence suggests that peripheral airways and parenchyma are
involved in asthma, we hypothesized that significant alveolar tissue inflammation is present …