[HTML][HTML] The discovery of α1-antitrypsin and its role in health and disease

SM Janciauskiene, R Bals, R Koczulla… - Respiratory …, 2011 - Elsevier
… By 1975, Carrell and co-workers were able to show that the S variant is due to the substitution
of a glutamic acid by a valine at position 264 in AAT. Soon after this, the abnormality of Z …

Latest developments in metal complexes as anticancer agents

…, M Wiese-Szadkowska, S Janciauskiene… - Coordination Chemistry …, 2022 - Elsevier
Every year novel biologically active compounds are designed as antitumor agents. This
review covers and highlights some of the most important findings described during 2018–2020 …

[HTML][HTML] Conformational properties of serine proteinase inhibitors (serpins) confer multiple pathophysiological roles

S Janciauskiene - Biochimica Et Biophysica Acta (BBA)-Molecular Basis …, 2001 - Elsevier
… The most widely studied deficiency variants of AAT are Z and S, which have E342K and
E264V mutations respectively [54], [55]. Polymerisation of AAT is also known to be involved in …

OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation

…, M Gattorno, V Grau, S Janciauskiene… - Proceedings of the …, 2018 - National Acad Sciences
Activation of the NLRP3 inflammasome induces maturation of IL-1β and IL-18, both validated
targets for treating acute and chronic inflammatory diseases. Here, we demonstrate that …

Anti-inflammatory and immunomodulatory properties of α1-antitrypsin without inhibition of elastase

…, CA Dinarello, S Janciauskiene - Proceedings of the …, 2013 - National Acad Sciences
… Different varieties of electroconductive wood are widely reported; however, modulating the
wood’s ...The nature of mass transport in plants has recently inspired the development of low-…

Recombinant human antibodies against aldehyde-modified apolipoprotein B-100 peptide sequences inhibit atherosclerosis

…, I Söderberg, S Janciauskiene, S Lindgren… - Circulation, 2004 - Am Heart Assoc
Background— Accumulation and oxidation of LDL are believed to be important initiating
factors in atherosclerosis. Oxidized LDL is recognized by the immune system, and animal …

[HTML][HTML] Large-scale hematopoietic differentiation of human induced pluripotent stem cells provides granulocytes or macrophages for cell replacement therapies

…, MP Kühnel, A Schambach, S Janciauskiene… - Stem cell reports, 2015 - cell.com
Interleukin-3 (IL-3) is capable of supporting the proliferation of a broad range of hematopoietic
cell types, whereas granulocyte colony-stimulating factor (G-CSF) and macrophage CSF (…

[HTML][HTML] CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer's disease

…, P Buchhave, H Nielsen, L Minthon, S Janciauskiene… - PloS one, 2012 - journals.plos.org
… significantly associated with a higher annual decrease in MMSE score (r s = 0.42, p = 0.004;
Figure 1) and with a shorter time to conversion to AD (r s = −0.39, p = 0.006). When using …

Polymers of Z α1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo

…, C Atkinson, Z Li, S Stewart, S Janciauskiene… - The American journal of …, 2005 - Elsevier
The molecular mechanisms that cause emphysema are complex but most theories suggest
that an excess of proteinases is a crucial requirement. This paradigm is exemplified by …

[HTML][HTML] Plexiform lesions in pulmonary arterial hypertension: composition, architecture, and microenvironment

…, U Maus, U Lehmann, S Janciauskiene… - The American journal of …, 2011 - Elsevier
Pulmonary arterial hypertension (PAH) is a debilitating disease with a high mortality rate. A
hallmark of PAH is plexiform lesions (PLs), complex vascular formations originating from …