User profiles for T. Velkov
 | Tony VelkovMelbourne University Verified email at unimelb.edu.au Cited by 10417 |
Structure− activity relationships of polymyxin antibiotics
The world is facing an enormous and growing threat from the emergence of bacteria that
are resistant to almost all available antibiotics. 1 Multidrug resistance is a significant public …
are resistant to almost all available antibiotics. 1 Multidrug resistance is a significant public …
Pharmacology of polymyxins: new insights into an 'old'class of antibiotics
… J Li is an Australian National Health and Medical Research Council Senior Research
Fellow and T Velkov is an Australian National Health and Medical Research Council Industry …
Fellow and T Velkov is an Australian National Health and Medical Research Council Industry …
Rescuing the last-line polymyxins: achievements and challenges
Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …
Colistin and polymyxin B: peas in a pod, or chalk and cheese?
Colistin and polymyxin B have indistinguishable microbiological activity in vitro, but they differ
in the form administered parenterally to patients. Polymyxin B is administered directly as …
in the form administered parenterally to patients. Polymyxin B is administered directly as …
[HTML][HTML] Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination
… To determine the potency and efficacy, the effect of VX-445 EN1 and the Velkov lab preparation
were … For subsequent experiments, the Velkov lab preparation of VX-445 was used. …
were … For subsequent experiments, the Velkov lab preparation of VX-445 was used. …
[HTML][HTML] A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity
… Tony Velkov … Velkov, T et al. Surface changes and polymyxin interactions with a
resistant strain of Klebsiella pneumoniae. Innate Immun. … Tony Velkov …
resistant strain of Klebsiella pneumoniae. Innate Immun. … Tony Velkov …
Pharmacokinetics/pharmacodynamics of colistin and polymyxin B: are we there yet?
The polymyxin antibiotics [colistin and polymyxin B (PMB)] are increasingly used as a last-line
option for the treatment of infections caused by extensively drug-resistant Gram-negative …
option for the treatment of infections caused by extensively drug-resistant Gram-negative …
The rise and spread of mcr plasmid-mediated polymyxin resistance
Polymyxins are important lipopeptide antibiotics that serve as the last-line defense against
multidrug-resistant (MDR) Gram-negative bacterial infections. Worryingly, the clinical utility of …
multidrug-resistant (MDR) Gram-negative bacterial infections. Worryingly, the clinical utility of …
[HTML][HTML] The natural product curcumin as an antibacterial agent: Current achievements and problems
The rapid spread of antibiotic resistance and lack of effective drugs for treating infections
caused by multi-drug resistant bacteria in animal and human medicine have forced us to find …
caused by multi-drug resistant bacteria in animal and human medicine have forced us to find …
Antimicrobial activity and toxicity of the major lipopeptide components of polymyxin B and colistin: last-line antibiotics against multidrug-resistant Gram-negative …
Polymyxin B and colistin are currently used as a “last-line” treatment for multidrug-resistant
Gram-negative bacteria. However, very little is known about the pharmacological differences …
Gram-negative bacteria. However, very little is known about the pharmacological differences …