Background The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
might be curtailed by vaccination. We assessed the safety, reactogenicity, and …

The influenza pandemic of 1918–19 was responsible for about 50 million deaths worldwide
1 . Modern histopathological analysis of autopsy samples from human influenza cases from …

The NS1 protein of influenza A virus contributes to viral pathogenesis, primarily by enabling
the virus to disarm the host cell type IFN defense system. We examined the downstream …

Few animal models are currently in use for the recognized clinical problem of nicotine
dependence and abstinence. This study introduces a rapid and convenient model using the rat. …

Background Poor inhaler technique has been linked to poor asthma outcomes. Training can
reduce the number of inhaler errors, but it is unknown which errors have the greatest impact …

Existing mouse models of lethal Ebola virus infection do not reproduce hallmark symptoms
of Ebola hemorrhagic fever, neither delayed blood coagulation and disseminated …

A novel human coronavirus (HCoV-EMC) was recently identified in the Middle East as the
causative agent of a severe acute respiratory syndrome (SARS) resembling the illness caused …

The enormous toll on human life during the 1918–1919 Spanish influenza pandemic is a
constant reminder of the potential lethality of influenza viruses. With the declaration by the …

Background Clinical characteristics of the international population with severe asthma are
unknown. Intercountry comparisons are hindered by variable data collection within regional …

We studied the effect of filovirus infection on host cell gene expression by characterizing the
regulation of gene expression responses in human liver cells infected with Zaire Ebolavirus (…