Background Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with
high mortality, uncertain cause, and few treatment options. Studies have identified a significant …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by
scarring of the lung that is believed to result from an atypical response to injury of the …

Background Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disorder with a variable
disease trajectory. The aim of this study was to assess potential biomarkers to predict …

… Thielemans, FJ Wilson, PF Mercer, RC Chambers and WA Fahy made substantial
contributions to the acquisition, analysis, or interpretation of data for the study. All the authors …

Idiopathic pulmonary fibrosis (IPF) is characterised by excessive extracellular matrix (ECM)
deposition and remodelling. Measuring this activity provides an opportunity to develop tools …

Background Idiopathic pulmonary fibrosis (IPF) is an incurable lung disease characterised by
progressive scarring leading to alveolar stiffness, reduced lung capacity, and impeded gas …

BACKGROUND: Neutrophil elastase (NE) is implicated in chronic obstructive pulmonary
disease (COPD). AZD9668 is a reversible and selective inhibitor of NE, well tolerated at doses …

Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with
poor prognosis and a significant unmet medical need. This study evaluated the safety, …

Purpose The RGD-integrin, αvβ6, plays a role in the pathogenesis of pulmonary fibrosis
through activation of transforming growth factor beta (TGFβ). This study sought to quantify …

Background Minimizing the risk of disease progression and exacerbations is the key goal of
COPD management, as these are well-established indicators of poor COPD prognosis. We …