Inflammasome signaling and regulation of interleukin-1 family cytokines
AH Chan, K Schroder - Journal of Experimental Medicine, 2019 - rupress.org
Specific IL-1 family cytokines are expressed by cells as cytosolic pro-forms that require cleavage
for their activity and cellular release. IL-1β, IL-18, and IL-37 maturation and secretion is …
for their activity and cellular release. IL-1β, IL-18, and IL-37 maturation and secretion is …
Inflammatory caspases: toward a unified model for caspase activation by inflammasomes
Inflammasomes are inflammatory signaling complexes that provide molecular platforms to
activate the protease function of inflammatory caspases. Caspases-1, -4, -5, and -11 are …
activate the protease function of inflammatory caspases. Caspases-1, -4, -5, and -11 are …
Bandwidth aggregation in heterogeneous wireless networks: A survey of current approaches and issues
AL Ramaboli, OE Falowo, AH Chan - Journal of Network and Computer …, 2012 - Elsevier
Future wireless networks are envisaged to consist of a variety of integrated and jointly managed
radio access technologies (RATs). This is motivated by the complementary features of …
radio access technologies (RATs). This is motivated by the complementary features of …
[PDF][PDF] CRISPR interference efficiently induces specific and reversible gene silencing in human iPSCs
…, EB Frolov, E Shin, A Truong, MP Olvera, AH Chan… - Cell stem cell, 2016 - cell.com
Developing technologies for efficient and scalable disruption of gene expression will
provide powerful tools for studying gene function, developmental pathways, and disease …
provide powerful tools for studying gene function, developmental pathways, and disease …
Sorption and transport of various gases in polycarbonate
WJ Koros, AH Chan, DR Paul - Journal of Membrane Science, 1977 - Elsevier
The solubility, permeability, and diffusion time lag for CO 2 , CH 4 , Ar, N 2 , and He in
polycarbonate are reported at 35C for pressures ranging from 1 atm to 20 atm. The solubility data …
polycarbonate are reported at 35C for pressures ranging from 1 atm to 20 atm. The solubility data …
Two‐and three‐dimensional rings in drugs
Using small, flat aromatic rings as components of fragments or molecules is a common practice
in fragment‐based drug discovery and lead optimization. With an increasing focus on the …
in fragment‐based drug discovery and lead optimization. With an increasing focus on the …
[HTML][HTML] Genome-Wide Fine-Scale Recombination Rate Variation in Drosophila melanogaster
AH Chan, PA Jenkins, YS Song - PLoS genetics, 2012 - journals.plos.org
Estimating fine-scale recombination maps of Drosophila from population genomic data is a
challenging problem, in particular because of the high background recombination rate. In this …
challenging problem, in particular because of the high background recombination rate. In this …
Isolation of single-base genome-edited human iPS cells without antibiotic selection
Precise editing of human genomes in pluripotent stem cells by homology-driven repair of
targeted nuclease–induced cleavage has been hindered by the difficulty of isolating rare clones…
targeted nuclease–induced cleavage has been hindered by the difficulty of isolating rare clones…
[HTML][HTML] Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing
…, JR Berman, SB Cooper, SJ Mayerl, AH Chan… - Scientific reports, 2016 - nature.com
Precise genome-editing relies on the repair of sequence-specific nuclease-induced DNA
nicking or double-strand breaks (DSBs) by homology-directed repair (HDR). However, …
nicking or double-strand breaks (DSBs) by homology-directed repair (HDR). However, …
The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site
B Chen, J Mariano, YC Tsai, AH Chan… - Proceedings of the …, 2006 - National Acad Sciences
Efficient targeting of proteins for degradation from the secretory pathway is essential to
homeostasis. This occurs through endoplasmic reticulum (ER)-associated degradation (ERAD). …
homeostasis. This occurs through endoplasmic reticulum (ER)-associated degradation (ERAD). …