User profiles for D. R. Thickett

Thickett d

University of birmingham
Verified email at bham.ac.uk
Cited by 10724

Cigarette smoke exposure and alveolar macrophages: mechanisms for lung disease

ST Lugg, A Scott, D Parekh, B Naidu, DR Thickett - Thorax, 2022 - thorax.bmj.com
… David R Thickett … With regards to cell surface markers, M1 are typically characterised by
expression of HLA-DR, CD14 and CD38, while M2 are characterised by CD36, CD206 and …

Epithelial–mesenchymal transition in lung development and disease: does it exist and is it important?

D Bartis, N Mise, RY Mahida, O Eickelberg, DR Thickett - Thorax, 2014 - thorax.bmj.com
… David R Thickett1 … Correspondence to Dr Domokos Bartis, Department of Clinical
Respiratory Sciences, Centre for Translational Inflammation and Fibrosis Research, University of …

The vitamin D axis in the lung: a key role for vitamin D-binding protein

L Chishimba, DR Thickett, RA Stockley, AM Wood - Thorax, 2010 - thorax.bmj.com
There has been much recent interest in the role of the vitamin D axis in lung disease, which
includes vitamin D, vitamin D receptor (VDR) and vitamin D-binding protein (VDBP; also …

The β-Agonist Lung Injury Trial (BALTI) a randomized placebo-controlled clinical trial

GD Perkins, DF McAuley, DR Thickett… - American journal of …, 2006 - atsjournals.org
Rationale: Experimental data suggest that manipulation of alveolar fluid clearance with β-agonists
can accelerate the resolution of alveolar edema and improve survival. Objective: To …

[HTML][HTML] Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS)

…, DM Sansom, AR Martineau, GD Perkins, DR Thickett - Thorax, 2015 - thorax.bmj.com
Rationale Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and
intensive therapy unit mortality but has not been assessed as a risk factor for acute respiratory …

[HTML][HTML] Pro-inflammatory effects of e-cigarette vapour condensate on human alveolar macrophages

…, D Parekh, R Foronjy, E Sapey, B Naidu, DR Thickett - Thorax, 2018 - thorax.bmj.com
Objective Vaping may increase the cytotoxic effects of e-cigarette liquid (ECL). We
compared the effect of unvaped ECL to e-cigarette vapour condensate (ECVC) on alveolar …

Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers

…, TR Craig, V Brown, DR Thickett… - American journal of …, 2009 - atsjournals.org
Rationale: Simvastatin inhibits inflammatory responses in vitro and in murine models of lung
inflammation in vivo. As simvastatin modulates a number of the underlying processes …

Vascular endothelial growth factor may contribute to increased vascular permeability in acute respiratory distress syndrome

DR Thickett, L Armstrong, SJ Christie… - American journal of …, 2001 - atsjournals.org
The development of noncardiogenic pulmonary edema is a characteristic feature of acute
respiratory distress syndrome (ARDS). We hypothesized that vascular endothelial growth …

MMP expression and abnormal lung permeability are important determinants of outcome in IPF

…, C O'Kane, DF McAuley, DR Thickett - European …, 2009 - Eur Respiratory Soc
Matrix metalloproteinases (MMPs) degrade all of the extracellular matrix components of the
intersititium and may play a role in abnormal alveolar permeability, which is a feature of …

Long-term impact of developing a postoperative pulmonary complication after lung surgery

…, MS Kalkat, RS Steyn, PB Rajesh, DR Thickett… - Thorax, 2016 - thorax.bmj.com
… David R Thickett1, … Mortality Statistics: Deaths Registered in England and Wales (Series
DR), 2013. http://www.ons.gov.uk/ons/rel/vsob1/mortality-statistics–deaths-registered-in-england-…