User profiles for J. C. Watts

Joel C. Watts

Associate Professor, University of Toronto
Verified email at utoronto.ca
Cited by 5760

Antiviral activity of 1-adamantanamine (amantadine)

…, JW McGahen, EM Neumayer, M Paulshock, JC Watts… - Science, 1964 - science.org
1-Adamantanamine (amantadine) causes a selective, reproducible, dose-related inhibition
of influenza infections in tissue culture, chick embryos, and mice. The compound is not …

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

…, AL Woerman, DA Mordes, JC Watts… - Proceedings of the …, 2015 - National Acad Sciences
Prions are proteins that adopt alternative conformations that become self-propagating; the
PrP Sc prion causes the rare human disorder Creutzfeldt–Jakob disease (CJD). We report …

Transmission of multiple system atrophy prions to transgenic mice

JC Watts, K Giles, A Oehler… - Proceedings of the …, 2013 - National Acad Sciences
Prions are proteins that adopt alternative conformations, which become self-propagating.
Increasing evidence argues that prions feature in the synucleinopathies that include Parkinson’…

Purified and synthetic Alzheimer's amyloid beta (Aβ) prions

J Stöhr, JC Watts, ZL Mensinger… - Proceedings of the …, 2012 - National Acad Sciences
The aggregation and deposition of amyloid-β (Aβ) peptides are believed to be central
events in the pathogenesis of Alzheimer’s disease (AD). Inoculation of brain homogenates …

Inner volume MR imaging: technical concepts and their application.

…, JC Hoenninger, LE Crooks, L Kaufman, JC Watts… - Radiology, 1985 - pubs.rsna.org
Although cross-sectional magnetic resonance examination of the head and body is useful for
screening large regions of tissue, subsectional regions of the head and body often need to …

Halving MR imaging time by conjugation: demonstration at 3.5 kG.

DA Feinberg, JD Hale, JC Watts, L Kaufman, A Mark - Radiology, 1986 - pubs.rsna.org
Conjugation can be used to synthesize half of the data acquired during a conventional two-dimensional
Fourier transform imaging procedure, thus reducing imaging time by nearly half. …

Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients

JC Watts, C Condello, J Stöhr… - Proceedings of the …, 2014 - National Acad Sciences
An increasing number of studies argues that self-propagating protein conformations (ie,
prions) feature in the pathogenesis of several common neurodegenerative diseases. Mounting …

Effects of fear and instructions on how to cope with danger.

H Leventhal, JC Watts, F Pagano - Journal of personality and …, 1967 - psycnet.apa.org
… But more data are needed to decide the point, since only in Leventhal and Watts (1966) were
changes in smoking behavior measured, and in this study the measures were taken at only …

α-Synuclein strains target distinct brain regions and cell types

…, H Wille, M Ingelsson, D Klenerman, JC Watts - Nature …, 2020 - nature.com
The clinical and pathological differences between synucleinopathies such as Parkinson’s
disease and multiple system atrophy have been postulated to stem from unique strains of α-…

Propagation of prions causing synucleinopathies in cultured cells

…, Z Krejciova, JC Watts… - Proceedings of the …, 2015 - National Acad Sciences
Increasingly, evidence argues that many neurodegenerative diseases, including progressive
supranuclear palsy (PSP), are caused by prions, which are alternatively folded proteins …