Addressing the complexity of chronic obstructive pulmonary disease: from phenotypes and biomarkers to scale-free networks, systems biology, and P4 medicine
… to patients with COPD with chronic respiratory failure, in whom a specific type of treatment
(domiciliary oxygen therapy) has been shown to improve prognosis below a given arterial Po …
(domiciliary oxygen therapy) has been shown to improve prognosis below a given arterial Po …
P4 medicine: the future around the corner
P Sobradillo, F Pozo, Á Agustí - Archivos de Bronconeumología ((English …, 2011 - Elsevier
… Perhaps the most important property that characterizes the structure of a complex network
is the P(k) function of link distribution, which gives information about the probability of a …
is the P(k) function of link distribution, which gives information about the probability of a …
Fenotipos clínicos de la EPOC
P Sobradillo, J García-Aymerich, À Agustí - Archivos de Bronconeumología, 2010 - Elsevier
… Este último es un concepto bien establecido en otras enfermedades (p. ej., artritis reumatoide)
pero no en la EPOC. Recientemente, hemos propuesto que la gravedad de la …
pero no en la EPOC. Recientemente, hemos propuesto que la gravedad de la …
Mortality prediction in chronic obstructive pulmonary disease comparing the GOLD 2007 and 2011 staging systems: a pooled analysis of individual patient data
…, MA Puhan, P Sobradillo, P Lange… - The Lancet …, 2015 - thelancet.com
Background There is no universal consensus on the best staging system for chronic obstructive
pulmonary disease (COPD). Although documents (eg, the Global Initiative for Chronic …
pulmonary disease (COPD). Although documents (eg, the Global Initiative for Chronic …
[HTML][HTML] Sex differences between women and men with COPD: a new analysis of the 3CIA study
…, G Ter Riet, P Sobradillo, P Lange… - Respiratory …, 2020 - Elsevier
… p < 0.05). On symptoms, women reported more dyspnea, equal cough but less expectoration
(p … There were no differences in the BODE index score in women (2.4) versus men (2.4) (p = …
(p … There were no differences in the BODE index score in women (2.4) versus men (2.4) (p = …
Large-scale international validation of the ADO index in subjects with COPD: an individual subject data analysis of 10 cohorts
…, NN Hansel, P Sobradillo, P Enright, P Lange… - BMJ open, 2012 - bmjopen.bmj.com
… The original ADO index showed high discrimination but poor calibration (p<0.001 for
difference between predicted and observed risk). The updated ADO index (scores from 0 to 14) …
difference between predicted and observed risk). The updated ADO index (scores from 0 to 14) …
A simple algorithm for the identification of clinical COPD phenotypes
…, AS Ramírez, DD Sin, P Sobradillo… - European …, 2017 - Eur Respiratory Soc
This study aimed to identify simple rules for allocating chronic obstructive pulmonary disease
(COPD) patients to clinical phenotypes identified by cluster analyses. Data from 2409 …
(COPD) patients to clinical phenotypes identified by cluster analyses. Data from 2409 …
Enfermedad pulmonar obstructiva crónica en mujeres:¿ somos diferentes?
T Alonso, P Sobradillo… - Arch. bronconeumol.(Ed …, 2017 - pesquisa.bvsalud.org
… Alonso, Tamara; Sobradillo, Patricia; Torres, Juan P de. … Sobradillo, Patricia; Hospital
Universitario Araba. Servicio de Neumología. Vitoria-Gasteiz. … Torres, Juan P de; Clínica …
Universitario Araba. Servicio de Neumología. Vitoria-Gasteiz. … Torres, Juan P de; Clínica …
The inflammasome pathway in stable COPD and acute exacerbations
R Faner, P Sobradillo, A Noguera, C Gomez… - ERJ open …, 2016 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) is characterised by pulmonary and systemic
inflammation that bursts during exacerbations of the disease (ECOPD). The NLRP3 …
inflammation that bursts during exacerbations of the disease (ECOPD). The NLRP3 …
[HTML][HTML] Large-scale external validation and comparison of prognostic models: an application to chronic obstructive pulmonary disease
…, BR Celli, JM Marin, G Ter Riet, P Sobradillo, P Lange… - BMC medicine, 2018 - Springer
Background External validations and comparisons of prognostic models or scores are a
prerequisite for their use in routine clinical care but are lacking in most medical fields including …
prerequisite for their use in routine clinical care but are lacking in most medical fields including …