Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease?

W Broekman, PPSJ Khedoe, K Schepers, H Roelofs… - Thorax, 2018 - thorax.bmj.com
COPD is characterised by tissue destruction and inflammation. Given the lack of curative
treatments and the progressive nature of the disease, new treatments for COPD are highly …

A phase I study for intravenous autologous mesenchymal stromal cell administration to patients with severe emphysema

J Stolk, W Broekman, T Mauad… - … Journal of Medicine, 2016 - academic.oup.com
Background: Mesenchymal stromal cells (MSCs) may reduce inflammation and promote tissue
repair in pulmonary emphysema. Aim: To study the safety and feasibility of bone marrow-…

[HTML][HTML] TNF-α and IL-1β-activated human mesenchymal stromal cells increase airway epithelial wound healing in vitro via activation of the epidermal growth factor …

W Broekman, GD Amatngalim, Y de Mooij-Eijk… - Respiratory …, 2016 - Springer
Background Mesenchymal stromal cells (MSCs) are investigated for their potential to reduce
inflammation and to repair damaged tissue. Inflammation and tissue damage are hallmarks …

[HTML][HTML] Cigarette smoke modulates repair and innate immunity following injury to airway epithelial cells

GD Amatngalim, W Broekman, NM Daniel… - PLoS …, 2016 - journals.plos.org
Cigarette smoking is the main risk factor associated with chronic obstructive pulmonary
disease (COPD), and contributes to COPD development and progression by causing epithelial …

[HTML][HTML] Pessary treatment for pelvic organ prolapse and health-related quality of life: a review

BHC Lamers, BMW Broekman, AL Milani - International urogynecology …, 2011 - Springer
Pessaries have been used to treat women with pelvic organ prolapse (POP) since the
beginning of recorded history. This review aims to assess the effect of pessary treatment on the …

Diagnostic yield of bacteriological tests and predictors of severe outcome in adult patients with COVID-19 presenting to the emergency department

…, N van Burgel, T Ottens, W Broekman… - Emergency Medicine …, 2021 - emj.bmj.com
Background Guidelines recommend maximal efforts to obtain blood and sputum cultures in
patients with COVID-19, as bacterial coinfection is associated with worse outcomes. The aim …

Functional characterisation of bone marrow-derived mesenchymal stromal cells from COPD patients

W Broekman, H Roelofs, MC Zarcone… - ERJ Open …, 2016 - Eur Respiratory Soc
Autologous bone marrow-derived mesenchymal stromal cells (BM-MSCs) are evaluated for
clinical use in chronic obstructive pulmonary disease (COPD) patients, but it is unclear …

The polymerisation of 4‐chloropyridine

JP Wibaut, FW Broekman - Recueil des Travaux Chimiques …, 1959 - Wiley Online Library
W e studied the spontaneous transformation of pure 4-chloropyridine more closely in 1939 3.
In … W e were able to show that by the action of dilute solutions of oxalic acid and picric acid, …

Investigations on pyridine and quinoline derivatives:(42nd. Communication) The formation of (4‐pyridyl)‐pyridinium compounds from 4‐chloropyridine and 4 …

JP Wibaut, FW Broekman - Recueil des Travaux Chimiques …, 1939 - Wiley Online Library
W e have worked out a preparative method for 4-chloropyridine by the action of phosphorus
… This method is more satisfactory than that of B obra ns ki, K o ch an s k a and K o wa 1 e w s …

Components in soy allergy diagnostics: Gly m 2S albumin has the best diagnostic value in adults

…, SGMA Pasmans, W de Kruijf‐Broekman… - Allergy, 2013 - Wiley Online Library
Background Thus far, four soy allergens have been characterized. Their diagnostic value was
assessed only using a case‐control design with controls not suspected of soy allergy or in …