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The effects of dual IQOS and cigarette smoke exposure on airway epithelial cells: implications for lung health and respiratory disease pathogenesis
The use of multiple electronic nicotine delivery products is on the rise. While the potential harm associated with dual- or poly-product usage is not yet clear, this study suggests that dual cigarette smoke and IQOS may be detrimental to lung health.
Clinical trial simulations in pulmonary fibrosis: patient-focused insights and adaptations
Insights were harnessed through simulations of planned trials in patients with pulmonary fibrosis, caregivers and healthcare professionals. Findings were analysed in patient and expert advisory boards, and patient-friendly changes to the trials were made.
Expansion of ST2-expressing macrophages in a patient with bronchiolitis obliterans syndrome
This case study of a patient with BOS after HSCT found increased ST2+CD64+ macrophages in BALF, a potential therapeutic target for treatment-refractory BOS, and reduced CCR2+CD14+ monocytes compared to other lung disorders
Computed tomography measure of lung injury and future interstitial features: the CARDIA Lung Study
“CT lung injury” is an objective computed tomography feature that is associated with future interstitial features and restrictive spirometry
Azithromycin alters spatial and temporal dynamics of airway microbiota in idiopathic pulmonary fibrosis
In IPF, azithromycin alters the dynamics of the microbiota between the upper and lower airways and community turnover over time, with a decrease in richness without impacting the bacterial density.

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