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All-cause admissions following a first ever exacerbation-related hospitalisation in COPD
Nonrespiratory events are the predominant cause of hospital admission in patients with COPD following their first ever exacerbation-related hospitalisation. These findings challenge the current global post-exacerbation management goals.
The trajectory of COVID-19 cardiopulmonary disease: insights from an autopsy study of community-based, pre-hospital deaths
Heterogeneous, overlapping and severe cardiopulmonary histopathological states occur following COVID-19 deaths in the community. Explanations for this were previously lacking and include unsensed hypoxaemia, rapid progression and psychosocial factors
Early-life risk factors for development of asthma from 8 to 28 years of age: a prospective cohort study
The incidence of asthma is high during childhood and teenage but decreases substantially during young adulthood. This study identified early-life risk factors for asthma in childhood; some remained important throughout teenage years and young adulthood.
Arterial remodelling in smokers and in patients with small airway disease and COPD: implications for lung physiology and early origins of pulmonary hypertension
Pulmonary arterial remodelling occurs in smokers and in patients with small airway disease or COPD, where it affects lung function and may exaggerate pulmonary hypertension. Endothelial-to-mesenchymal transition might be central to these vascular changes.
Immunophenotypes of anti-SARS-CoV-2 responses associated with fatal COVID-19
By employing unsupervised machine learning, this study identified multiple anti-SARS-CoV-2 immune response profiles and observed major differences in COVID-19 mortality between these profiles

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ERJ Open Research Jan 2023, 00479-2022; DOI: 10.1183/23120541.00479-2022
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ERJ Open Research Jan 2023, 00389-2022; DOI: 10.1183/23120541.00389-2022
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ERJ Open Research Jan 2023, 00651-2022; DOI: 10.1183/23120541.00651-2022
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Jieping Lei, Ke Huang, Jun Pan, Wei Li, Hongtao Niu, Xiaoxia Ren, Fen Dong, Yong Li, Baicun Li, Cunbo Jia, Ting Yang, Chen Wang

ERJ Open Research Jan 2023, 00597-2022; DOI: 10.1183/23120541.00597-2022
Impact of remote vital sign monitoring on health outcomes in acute respiratory infection and exacerbation of chronic respiratory conditions: systematic review and meta-analysis
Samuel Thomas Creavin, Megha Garg, Alastair D. Hay

ERJ Open Research Jan 2023, 00393-2022; DOI: 10.1183/23120541.00393-2022
Incidence of cognitive impairment and dementia after hospitalisation for pneumonia: a UK population-based matched cohort study
Christos V. Chalitsios, Vadsala Baskaran, Rowan H. Harwood, Wei Shen Lim, Tricia M. McKeever

ERJ Open Research Jan 2023, 00328-2022; DOI: 10.1183/23120541.00328-2022