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Validity of the diagnosis of pneumonia in hospitalised patients with COPD
Pneumonia is common in hospitalised COPD patients but is frequently not recognised and underdiagnosed. This has implications for the correct risk stratification and treatment of COPD patients.
The long-term effect of an exercise and diet intervention in asthma patients: a 1-year follow-up on a randomised controlled trial
This study provides evidence that improvements in maximal oxygen uptake prompted by a 2-month spinning programme regress to pre-intervention values. However, results suggest the presence of long-lasting improvements in self-reported asthma control.
Does oxygen pulse trajectory during incremental exercise discriminate impaired oxygen delivery from poor muscle oxygen utilisation?
A flattened or decreasing O2 pulse trajectory during incremental CPET is commonly found in patents with low exercise stroke volume but not in those with severely impaired muscle O2 utilisation. This finding should prompt additional cardiovascular work-up.
Clinical development of triple-combination CFTR modulators for cystic fibrosis patients with one or two F508del alleles
An efficient development programme for VX-659 and VX-445 in triple combination with tezacaftor/ivacaftor in patients with CF with one or two F508del-CFTR alleles was designed based on extensive CFTR modulator experience and pre-clinical and clinical data.
Cystic fibrosis disease severity correlates with plasma levels of desmosine and isodesmosine, biomarkers of elastin degradation
Novel methodological approaches now demonstrate that the unique elastin degradation products desmosine and isodesmosine are detectable in plasma of cystic fibrosis patients and correlate to lung function, exacerbation frequency and disease progression

Latest Articles

The long-term effect of an exercise and diet intervention in asthma patients: a 1-year follow-up on a randomised controlled trial
Adrian Koch Bentzon, Linda Wolfgang Loehde, Vibeke Backer, Louise Toennesen

ERJ Open Research Apr 2019, 5 (2) 00032-2019; DOI: 10.1183/23120541.00032-2019
Validity of the diagnosis of pneumonia in hospitalised patients with COPD
Lydia J. Finney, Vijay Padmanaban, Samuel Todd, Nadia Ahmed, Sarah L. Elkin, Patrick Mallia

ERJ Open Research Apr 2019, 5 (2) 00031-2019; DOI: 10.1183/23120541.00031-2019
Does oxygen pulse trajectory during incremental exercise discriminate impaired oxygen delivery from poor muscle oxygen utilisation?
Luiza H. Degani-Costa, Luiz E. Nery, Maíra T. Rodrigues, Ana Cristina Gimenes, Eloara V. Ferreira, Jaquelina S. Ota-Arakaki, J. Alberto Neder, Roberta P. Ramos

ERJ Open Research Apr 2019, 5 (2) 00108-2018; DOI: 10.1183/23120541.00108-2018
Cystic fibrosis disease severity correlates with plasma levels of desmosine and isodesmosine, biomarkers of elastin degradation
Shuren Ma, Patrick Geraghty, Abdoulaye Dabo, Cormac McCarthy, N. Gerry McElvaney, Gerard M. Turino

ERJ Open Research Apr 2019, 5 (2) 00250-2018; DOI: 10.1183/23120541.00250-2018
Clinical development of triple-combination CFTR modulators for cystic fibrosis patients with one or two F508del alleles
Jennifer L. Taylor-Cousar, Marcus A. Mall, Bonnie W. Ramsey, Edward F. McKone, Elizabeth Tullis, Gautham Marigowda, Charlotte M. McKee, David Waltz, Samuel M. Moskowitz, Jessica Savage, Fengjuan Xuan, Steven M. Rowe

ERJ Open Research Apr 2019, 5 (2) 00082-2019; DOI: 10.1183/23120541.00082-2019
Highlights of thoracic oncology from the 2018 ERS International Congress
Polyxeni Ntontsi, Clementine Bostantzoglou, Torsten Gerriet Blum

ERJ Open Research Apr 2019, 5 (2) 00222-2018; DOI: 10.1183/23120541.00222-2018