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Severe pulmonary hypertension associated with lung disease is characterised by a loss of small pulmonary vessels on quantitative computed tomography
In patients with pulmonary hypertension associated with lung disease, reduced small pulmonary vessel volume on quantitative CT imaging identifies patients with severe pulmonary hypertension
Noninvasive diagnosis of pulmonary hypertension with hyperpolarised 129Xe magnetic resonance imaging and spectroscopy
Diagnostic models using 129Xe MRI/MRS metrics can noninvasively detect pre-capillary PH, post-capillary PH and ILD. The combination of 129Xe MRI/MRS provides a comprehensive assessment of haemodynamics and gas-exchange impairment in individual patients.
Lung involvement during the prediagnostic phase of idiopathic pleuroparenchymal fibroelastosis
Patients with PPFE sometimes have lung involvement at the lung apex long before the diagnosis. The prediagnostic phase with apical fibrosis is much longer than the postdiagnostic phase in patients with PPFE.
Heparan sulfate mimetic fucoidan restores the endothelial glycocalyx and protects against dysfunction induced by serum of COVID-19 patients in the intensive care unit
The heparan sulfate mimetic fucoidan reduces endothelial activation induced by severe COVID-19 serum, restores the endothelial glycocalyx and the cell–cell barrier, and reverses the endothelial pro-coagulable state
Autoimmune pulmonary alveolar proteinosis in children
In children, management of autoimmune pulmonary alveolar proteinosis is very challenging. We need to consider all treatment options, as the most effective one with the best harm-to-benefit ratio is unknown.

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