Lung biology and experimental studies

Lung biology and experimental studies

Reduced neutrophil elastase inhibitor elafin and elevated transforming growth factor-β₁ are linked to inflammatory response in sputum of cystic fibrosis patients with Pseudomonas aeruginosa
Jan C. Thomassen, Tobias Trojan, Maxine Walz, Christina Vohlen, Gregor Fink, Ernst Rietschel, Miguel A. Alejandre Alcazar, Silke van Koningsbruggen-Rietschel

ERJ Open Research Jul 2021, 7 (3) 00636-2020; DOI: 10.1183/23120541.00636-2020
Development and validation of a mouse model of contemporary cannabis smoke exposure
Matthew F. Fantauzzi, Steven P. Cass, Joshua J.C. McGrath, Danya Thayaparan, Peiyao Wang, Martin R. Stampfli, Jeremy A. Hirota

ERJ Open Research Jul 2021, 7 (3) 00107-2021; DOI: 10.1183/23120541.00107-2021
Airway monocyte modulation relates to tumour necrosis factor dysregulation in neutrophilic asthma
Natalie M. Niessen, Peter G. Gibson, Jodie L. Simpson, Hayley A. Scott, Katherine J. Baines, Michael Fricker

ERJ Open Research Jul 2021, 7 (3) 00131-2021; DOI: 10.1183/23120541.00131-2021
Vaping-induced metabolomic signatures in the circulation of mice are driven by device type, e-liquid, exposure duration and sex
Alexander Moshensky, Mulong Du, John Shin, Ira Advani, Deepti Gunge, Denzil Mathew, Rita Alkolla, Ashley Du, Christian Javier, Lauren Ma, Albert Tran, Nicholas Nguyen, Jarod Olay, Sedtavut Nilaad, Jeffrey Ding, Mahan Najhawan, Jeramie D. Watrous, Christine M. Bojanowksi, Mohit Jain, David C. Christiani, Laura E. Crotty Alexander

ERJ Open Research Jul 2021, 7 (3) 00229-2021; DOI: 10.1183/23120541.00229-2021
Sex-specific longitudinal association of DNA methylation with lung function
Shadia Khan Sunny, Hongmei Zhang, Caroline L. Relton, Susan Ring, Latha Kadalayil, Fawaz Mzayek, Susan Ewart, John W. Holloway, S. Hasan Arshad

ERJ Open Research Jul 2021, 7 (3) 00127-2021; DOI: 10.1183/23120541.00127-2021
The sputum transcriptome better predicts COPD exacerbations after the withdrawal of inhaled corticosteroids than sputum eosinophils
Benedikt Ditz, Aartik Sarma, Huib A.M. Kerstjens, Jeroen J.W. Liesker, Erik Bathoorn, Judith M. Vonk, Victor Bernal, Peter Horvatovich, Victor Guryev, Saharai Caldera, Chaz Langelier, Alen Faiz, Stephanie A. Christenson, Maarten van den Berge

ERJ Open Research Jul 2021, 7 (3) 00097-2021; DOI: 10.1183/23120541.00097-2021
Phagocyte extracellular traps in children with neutrophilic airway inflammation
Paul T. King, Lovisa Dousha, Nadeene Clarke, Jennifer Schaefer, Rosemary Carzino, Roleen Sharma, Ken L. Wan, Aveena Anantharajah, Kim O'Sullivan, Zhong X. Lu, Stephen R. Holdsworth, Sarath Ranganathan, Philip G. Bardin, David S. Armstrong

ERJ Open Research Apr 2021, 7 (2) 00883-2020; DOI: 10.1183/23120541.00883-2020
COL4A3 expression in asthmatic epithelium depends on intronic methylation and ZNF263 binding
Sai Sneha Priya Nemani, Cornelis Joseph Vermeulen, Martin Pech, Alen Faiz, Brian George G. Oliver, Maarten van den Berge, Janette Kay Burgess, Matthias V. Kopp, Markus Weckmann

ERJ Open Research Apr 2021, 7 (2) 00802-2020; DOI: 10.1183/23120541.00802-2020
Increased myofibroblasts in the small airways, and relationship to remodelling and functional changes in smokers and COPD patients: potential role of epithelial–mesenchymal transition
Mathew Suji Eapen, Wenying Lu, Tillie L. Hackett, Gurpreet Kaur Singhera, Malik Q. Mahmood, Ashutosh Hardikar, Chris Ward, Eugene Haydn Walters, Sukhwinder Singh Sohal

ERJ Open Research Apr 2021, 7 (2) 00876-2020; DOI: 10.1183/23120541.00876-2020
Anti-HSP47 siRNA lipid nanoparticle ND-L02-s0201 reverses interstitial pulmonary fibrosis in preclinical rat models
Yun Liu, Jian Liu, Alistair Quimbo, Fengcheng Xia, Jiping Yao, Jean-Pierre Clamme, Sonya Zabludoff, Jun Zhang, Wenbin Ying

ERJ Open Research Apr 2021, 7 (2) 00733-2020; DOI: 10.1183/23120541.00733-2020

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