Lung biology and experimental studies

Cross-talk of inflammatory mediators and airway epithelium reveals the cystic fibrosis transmembrane conductance regulator as a major target
Filipa B. Simões, Arthur Kmit, Margarida D. Amaral

ERJ Open Research Oct 2021, 7 (4) 00247-2021; DOI: 10.1183/23120541.00247-2021
In vitro and in vivo modulation of NADPH oxidase activity and reactive oxygen species production in human neutrophils by α₁-antitrypsin
Padraig Hawkins, Thomas McEnery, Claudie Gabillard-Lefort, David A. Bergin, Bader Alfawaz, Vipatsorn Shutchaidat, Paula Meleady, Michael Henry, Orla Coleman, Mark Murphy, Noel G. McElvaney, Emer P. Reeves

ERJ Open Research Oct 2021, 7 (4) 00234-2021; DOI: 10.1183/23120541.00234-2021
The emerging role of proteases in α₁-antitrypsin deficiency and beyond
Aishath Fazleen, Tom Wilkinson

ERJ Open Research Oct 2021, 7 (4) 00494-2021; DOI: 10.1183/23120541.00494-2021
Inflammatory epithelial cytokines after in vitro respiratory syncytial viral infection are associated with reduced lung function
Wenming Duan, Yuchen Cen, Cindy Lin, Hong Ouyang, Kai Du, Anushree Kumar, Borui Wang, Julie Avolio, Hartmut Grasemann, Theo J. Moraes

ERJ Open Research Jul 2021, 7 (3) 00365-2021; DOI: 10.1183/23120541.00365-2021
A systematic review of the diagnostic accuracy of volatile organic compounds in airway diseases and their relation to markers of type-2 inflammation
Wadah Ibrahim, Sushiladevi Natarajan, Michael Wilde, Rebecca Cordell, Paul S. Monks, Neil Greening, Christopher E. Brightling, Rachael Evans, Salman Siddiqui

ERJ Open Research Jul 2021, 7 (3) 00030-2021; DOI: 10.1183/23120541.00030-2021
High serum granulocyte-colony stimulating factor characterises neutrophilic COPD exacerbations associated with dysbiosis
Arindam Chakrabarti, Jordan S. Mar, David F. Choy, Yi Cao, Nisha Rathore, Xiaoying Yang, Gaik W. Tew, Olga Li, Prescott G. Woodruff, Christopher E. Brightling, Michele Grimbaldeston, Stephanie A. Christenson, Mona Bafadhel, Carrie M. Rosenberger

ERJ Open Research Jul 2021, 7 (3) 00836-2020; DOI: 10.1183/23120541.00836-2020
Development and validation of a mouse model of contemporary cannabis smoke exposure
Matthew F. Fantauzzi, Steven P. Cass, Joshua J.C. McGrath, Danya Thayaparan, Peiyao Wang, Martin R. Stampfli, Jeremy A. Hirota

ERJ Open Research Jul 2021, 7 (3) 00107-2021; DOI: 10.1183/23120541.00107-2021
Reduced neutrophil elastase inhibitor elafin and elevated transforming growth factor-β₁ are linked to inflammatory response in sputum of cystic fibrosis patients with Pseudomonas aeruginosa
Jan C. Thomassen, Tobias Trojan, Maxine Walz, Christina Vohlen, Gregor Fink, Ernst Rietschel, Miguel A. Alejandre Alcazar, Silke van Koningsbruggen-Rietschel

ERJ Open Research Jul 2021, 7 (3) 00636-2020; DOI: 10.1183/23120541.00636-2020
Airway monocyte modulation relates to tumour necrosis factor dysregulation in neutrophilic asthma
Natalie M. Niessen, Peter G. Gibson, Jodie L. Simpson, Hayley A. Scott, Katherine J. Baines, Michael Fricker

ERJ Open Research Jul 2021, 7 (3) 00131-2021; DOI: 10.1183/23120541.00131-2021
Vaping-induced metabolomic signatures in the circulation of mice are driven by device type, e-liquid, exposure duration and sex
Alexander Moshensky, Mulong Du, John Shin, Ira Advani, Deepti Gunge, Denzil Mathew, Rita Alkolla, Ashley Du, Christian Javier, Lauren Ma, Albert Tran, Nicholas Nguyen, Jarod Olay, Sedtavut Nilaad, Jeffrey Ding, Mahan Najhawan, Jeramie D. Watrous, Christine M. Bojanowksi, Mohit Jain, David C. Christiani, Laura E. Crotty Alexander

ERJ Open Research Jul 2021, 7 (3) 00229-2021; DOI: 10.1183/23120541.00229-2021

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