Figures
- FIGURE 1
Physical lung model composed of a) a 3 L Hans Rudolph syringe, b) an attachment made from 18 flexible tubes, c) a helical mixer device inserted at the syringe entrance, and d) an adjustable syringe stopper.
- FIGURE 2
Bland–Altman plots of in vitro functional residual capacity (FRC) measurements on each device. Data are plotted as measured FRC minus lung model FRC, expressed as the absolute difference versus mean of measured and lung model FRC values. Absolute differences (circles), mean difference and upper and lower limits of agreement (mean difference±sd of differences) are shown as dashed lines. a) Woolcock in-house device; b) Exhalyzer D device; c) EasyOne Pro LAB device analysed in Version 2.01.00.09.
- FIGURE 3
Bland–Altman plots of in vivo functional residual capacity (FRC) measurements on each device. Data are plotted as body plethysmography FRC (FRCpleth) minus multiple-breath nitrogen washout (MBNW) FRC, expressed as the absolute difference versus mean of FRCpleth and MBNW FRC. Absolute differences (circles), mean difference and upper and lower limits of agreement (mean difference±sd of differences) are shown as dashed lines. a) Woolcock in-house device; b) Exhalyzer D device; c) EasyOne Pro LAB device analysed in Version 2.01.00.09.
Tables
- TABLE 1
In vitro functional residual capacity (FRC) measurements on each device
Lung model FRC volume Trials WIMR EM ndd v.2.00 ndd v.2.01 2.31 9 2.30±0.02 2.39±0.02 1.78±0.14 2.16±0.04 2.11 9 2.10±0.02 2.17±0.02 1.72±0.12 2.00±0.03 1.81 9 1.84±0.02 1.88±0.02 1.37±0.11 1.72±0.03 1.51 9 1.53±0.03 1.53±0.02 1.25±0.05 1.43±0.02 Data presented as mean±sd, unless otherwise stated. Measurements are in litres. WIMR: Woolcock in-house device; EM: Exhalyzer D device; ndd v.2.00: EasyOne Pro LAB device Version 2.00.01.05; ndd v.2.01: EasyOne Pro LAB device analysed in Version 2.01.00.09.
- TABLE 2
Differences in in vitro functional residual capacity (FRC) measurements from the lung model functional residual capacity for four different lung volumes
Lung model FRC volume Subjects WIMR EM ndd v.2.00 ndd v.2.01 Absolute Relative Absolute Relative Absolute Relative Absolute Relative 2.31 9 −0.01±0.02 −0.2±0.8% 0.07±0.02 3.3±1.0% −0.54±0.14 −23.4±6.1% −0.15±0.04 −6.3±1.7% 2.11 9 −0.01±0.02 −0.43±0.9% 0.06±0.02 2.9±0.9% −0.39±0.12 −18.5±5.7% −0.11±0.03 −5.2±1.5% 1.81 9 0.03±0.02 1.6±1.4% 0.07±0.02 3.7±1.0% −0.44±0.11 −24.1±6.4% −0.09±0.03 −4.7±1.6% 1.51 9 0.02±0.03 1.7±13.1% 0.02±0.02 1.1±1.3% −0.26±0.05 −17.1±3.0% −0.08±0.02 −5.0±1.2% Data presented as mean±sd, unless otherwise stated. Absolute measurements are in litres. WIMR: Woolcock in-house device; EM: Exhalyzer D device; ndd v.2.00: EasyOne Pro LAB device Version 2.00.01.05; ndd v.2.01: EasyOne Pro LAB device analysed in Version 2.01.00.09.
- TABLE 3
Subject demographics and standard lung function measurements
All subjects Controls Asthmatics Subjects n 29 20 9 Males/females n 12/17 8/12 4/5 Age years 37±12 36±12 37±13 Height cm 172±12 174±12.5 168±10 BMI kg·m−2 24.1±3.63 23.9±3.48 24.6±4.10 Smoking history pack-years 2.5±3.2 2.75±3.31 0.70±0.00 FEV1 L 3.66±0.93 3.75±0.93 3.47±0.95 FVC L 4.75±1.17 4.77±1.16 4.71±1.25 FEV1/FVC 0.77±0.06 0.79±0.05 0.74±0.08 TLC L 6.51±1.38 6.55±1.41 6.42±1.41 FRCpleth L 3.44±0.77 3.49±0.78 3.34±0.80 Data presented as mean±sd unless otherwise stated. BMI: body mass index; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; TLC: total lung capacity; FRCpleth: functional residual capacity measured using body plethysmography.
- TABLE 4
Differences in in vivo functional residual capacity (FRC) measurements from body plethysmography FRC on each device
Subjects n WIMR EM ndd v2.00 ndd v2.01 Absolute Relative Absolute Relative Absolute Relative Absolute Relative Controls 20 −0.13±0.46# −3.3±13.0% 0.17±0.41 4.7±11.8% −0.73±0.36 −20.6±8.9% −0.36±0.32 −10.1±8.4% Asthmatics 9 −0.24±0.45 −6.8±13.8% 0.01±0.39 0.12±12.0% −0.73±0.59 −20.7±15.3% −0.42±0.57 −11.2±15.8% All subjects 29 −0.17±0.45 −4.4±13.1% 0.12±0.40 3.3±11.8% −0.73±0.43 −20.6±11% −0.38±0.40 −10.5±10.9% Data presented as mean±sd, unless otherwise stated. Absolute measurements are in litres. WIMR: Woolcock in-house device; EM: Exhalyzer D device; ndd v.2.00: EasyOne Pro LAB device Version 2.00.01.05; ndd v.2.01: EasyOne Pro LAB device analysed in Version 2.01.00.09. #: missing data for one subject.
Supplementary Material
Please note: supplementary material is not edited by the Editorial Office, and is uploaded as it has been supplied by the author.
Description of MBNW devices 00011-2017_supp
Supplementary Material
G.G. King 00011-2017_King
