Aspergillus fumigatus-specific immunoglobulin levels in BALF of CF patients

Mia Goña-Höpler; Birgit Pfaller; Jonathan Argeny; Stefan Kanolzer; Saskia Gruber; Klara Schmidthaler; Sabine Renner; Edith Nachbaur; Petra Fucik; Andreas G. Glaser; Markus Debiasi; Zsolt Szépfalusi; Reto Crameri; Claudio Rhyner; Thomas Eiwegger

doi:10.1183/23120541.00067-2017

Aspergillus fumigatus-specific immunoglobulin levels in BALF of CF patients

Mia Goña-Höpler, Birgit Pfaller, Jonathan Argeny, Stefan Kanolzer, Saskia Gruber, Klara Schmidthaler, Sabine Renner, Edith Nachbaur, Petra Fucik, Andreas G. Glaser, Markus Debiasi, Zsolt Szépfalusi, Reto Crameri, Claudio Rhyner, Thomas Eiwegger

ERJ Open Research 2017 3: 00067-2017; DOI: 10.1183/23120541.00067-2017

Mia Goña-Höpler

1Dept of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria

7These authors contributed equally

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Birgit Pfaller

2Dept of Pediatrics, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Canada

7These authors contributed equally

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Jonathan Argeny

1Dept of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria

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Stefan Kanolzer

1Dept of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria

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Saskia Gruber

1Dept of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria

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Klara Schmidthaler

1Dept of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria

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Sabine Renner

1Dept of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria

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Edith Nachbaur

1Dept of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria

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Petra Fucik

1Dept of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria

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Andreas G. Glaser

3Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Zurich, Switzerland

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Markus Debiasi

1Dept of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria

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Zsolt Szépfalusi

1Dept of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria

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Reto Crameri

3Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Zurich, Switzerland

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Claudio Rhyner

3Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Zurich, Switzerland

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Thomas Eiwegger

1Dept of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria

4Division of Immunology and Allergy, Food allergy and Anaphylaxis Program, Dept of Paediatrics, The Hospital for Sick Children, Toronto, Canada

5Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada

6Depts of Pediatrics and Immunology, The University of Toronto, Toronto, Canada

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For correspondence: thomas.eiwegger@sickkids.ca

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FIGURE 1
a) In the presence of Aspergillus fumigatus, local IgA and IgG levels to A. fumigatus are significantly elevated; *: p<0.05. b–d) Exclusive IgE production in the lung was associated with a significantly higher lung function as compared to patients that had serum and bronchoalveolar lavage fluid (BALF) A. fumigatus-specific (AF)-IgE (p<0.05, Mann–Whitney U-test). FVC: forced vital capacity; FEV₁: forced expiratory volume in 1 s.

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