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The clinical utility of lung clearance index in early cystic fibrosis lung disease is not impacted by the number of multiple-breath washout trials

Rachel E. Foong, Alana J. Harper, Billy Skoric, Louise King, Lidija Turkovic, Miriam Davis, Charles C. Clem, Tim Rosenow, Stephanie D. Davis, Sarath Ranganathan, Graham L. Hall, Kathryn A. Ramsey on behalf of AREST CF
ERJ Open Research 2018 4: 00094-2017; DOI: 10.1183/23120541.00094-2017
Rachel E. Foong
1Telethon Kids Institute, Subiaco, Australia
2The Hospital for Sick Children, Toronto, ON, Canada
3School of Physiotherapy and Exercise Science, Curtin University, Bentley, Australia
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Alana J. Harper
1Telethon Kids Institute, Subiaco, Australia
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Billy Skoric
4Murdoch Children's Research Institute, Parkville, Australia
5Dept of Respiratory Medicine, The Royal Children's Hospital, Parkville, Australia
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Louise King
4Murdoch Children's Research Institute, Parkville, Australia
5Dept of Respiratory Medicine, The Royal Children's Hospital, Parkville, Australia
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Lidija Turkovic
1Telethon Kids Institute, Subiaco, Australia
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Miriam Davis
6Section of Pediatric Pulmonology, Allergy and Sleep Medicine, Dept of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA
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Charles C. Clem
6Section of Pediatric Pulmonology, Allergy and Sleep Medicine, Dept of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA
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Tim Rosenow
1Telethon Kids Institute, Subiaco, Australia
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Stephanie D. Davis
6Section of Pediatric Pulmonology, Allergy and Sleep Medicine, Dept of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA
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Sarath Ranganathan
5Dept of Respiratory Medicine, The Royal Children's Hospital, Parkville, Australia
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Graham L. Hall
1Telethon Kids Institute, Subiaco, Australia
3School of Physiotherapy and Exercise Science, Curtin University, Bentley, Australia
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  • For correspondence: Graham.Hall@telethonkids.org.au
Kathryn A. Ramsey
1Telethon Kids Institute, Subiaco, Australia
7Paediatric Respiratory Medicine, Inselspital, University of Bern, Bern, Switzerland
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Article Information

vol. 4 no. 1
DOI 
https://doi.org/10.1183/23120541.00094-2017

Published By 
European Respiratory Society
Online ISSN 
2312-0541
History 
  • Received July 26, 2017
  • Accepted November 24, 2017
  • Published online February 16, 2018.

Copyright & Usage 
Copyright ©ERS 2018 This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

Author Information

  1. Rachel E. Foong1,2,3,
  2. Alana J. Harper1,
  3. Billy Skoric4,5,
  4. Louise King4,5,
  5. Lidija Turkovic1,
  6. Miriam Davis6,
  7. Charles C. Clem6,
  8. Tim Rosenow1,
  9. Stephanie D. Davis6,
  10. Sarath Ranganathan5,
  11. Graham L. Hall1,3⇑ and
  12. Kathryn A. Ramsey1,7
  13. on behalf of AREST CF8
  1. 1Telethon Kids Institute, Subiaco, Australia
  2. 2The Hospital for Sick Children, Toronto, ON, Canada
  3. 3School of Physiotherapy and Exercise Science, Curtin University, Bentley, Australia
  4. 4Murdoch Children's Research Institute, Parkville, Australia
  5. 5Dept of Respiratory Medicine, The Royal Children's Hospital, Parkville, Australia
  6. 6Section of Pediatric Pulmonology, Allergy and Sleep Medicine, Dept of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA
  7. 7Paediatric Respiratory Medicine, Inselspital, University of Bern, Bern, Switzerland
  8. 8The full membership of the Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST CF) is available at www.arestcf.org
  1. Graham L. Hall, Children's Lung Health, Telethon Kids Institute, 100 Roberts Road, Subiaco, WA 6008, Australia. E-mail: Graham.Hall{at}telethonkids.org.au
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Funding

  • National Health and Medical Research Council

    APP513730
  • Cystic Fibrosis Foundation Therapeutics

    HALL14A0; SLY04A0; STICK09A0

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The clinical utility of lung clearance index in early cystic fibrosis lung disease is not impacted by the number of multiple-breath washout trials
Rachel E. Foong, Alana J. Harper, Billy Skoric, Louise King, Lidija Turkovic, Miriam Davis, Charles C. Clem, Tim Rosenow, Stephanie D. Davis, Sarath Ranganathan, Graham L. Hall, Kathryn A. Ramsey
ERJ Open Research Jan 2018, 4 (1) 00094-2017; DOI: 10.1183/23120541.00094-2017

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The clinical utility of lung clearance index in early cystic fibrosis lung disease is not impacted by the number of multiple-breath washout trials
Rachel E. Foong, Alana J. Harper, Billy Skoric, Louise King, Lidija Turkovic, Miriam Davis, Charles C. Clem, Tim Rosenow, Stephanie D. Davis, Sarath Ranganathan, Graham L. Hall, Kathryn A. Ramsey
ERJ Open Research Jan 2018, 4 (1) 00094-2017; DOI: 10.1183/23120541.00094-2017
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