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The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites

Elena K. Schneider, Rachel M. McQuade, Vincenzo C. Carbone, Felisa Reyes-Ortega, John W. Wilson, Brenda Button, Ayame Saito, Daniel P. Poole, Daniel Hoyer, Jian Li, Tony Velkov
ERJ Open Research 2018 4: 00127-2017; DOI: 10.1183/23120541.00127-2017
Elena K. Schneider
1Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia
2Dept of Pharmacology and Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Australia
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  • ORCID record for Elena K. Schneider
Rachel M. McQuade
3Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia
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Vincenzo C. Carbone
4Animal Science, AgResearch Limited, Palmerston North, New Zealand
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Felisa Reyes-Ortega
5Dept of Applied Physics, Sciences Faculty, University of Granada, Granada, Spain
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John W. Wilson
6Dept of Medicine, Monash University, The Alfred Hospital, Melbourne, Australia
7Cystic Fibrosis Service, The Alfred Hospital, Melbourne, Australia
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Brenda Button
6Dept of Medicine, Monash University, The Alfred Hospital, Melbourne, Australia
7Cystic Fibrosis Service, The Alfred Hospital, Melbourne, Australia
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Ayame Saito
3Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia
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Daniel P. Poole
3Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia
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Daniel Hoyer
2Dept of Pharmacology and Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Australia
8The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia
9Dept of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA
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Jian Li
10Monash Biomedicine Discovery Institute, Dept of Microbiology, Monash University, Clayton, Australia
11These two authors contributed equally to this work
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Tony Velkov
1Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia
2Dept of Pharmacology and Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Australia
11These two authors contributed equally to this work
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  • For correspondence: tony.velkov@unimelb.edu.au
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Article Information

vol. 4 no. 1
DOI 
https://doi.org/10.1183/23120541.00127-2017

Published By 
European Respiratory Society
Online ISSN 
2312-0541
History 
  • Received October 11, 2017
  • Accepted January 29, 2018
  • Published online March 13, 2018.

Copyright & Usage 
The content of this work is ©the authors or their employers. Design and branding are ©ERS 2018 This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

Author Information

  1. Elena K. Schneider1,2,
  2. Rachel M. McQuade3,
  3. Vincenzo C. Carbone4,
  4. Felisa Reyes-Ortega5,
  5. John W. Wilson6,7,
  6. Brenda Button6,7,
  7. Ayame Saito3,
  8. Daniel P. Poole3,
  9. Daniel Hoyer2,8,9,
  10. Jian Li10,11 and
  11. Tony Velkov1,2,11⇑
  1. 1Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia
  2. 2Dept of Pharmacology and Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Australia
  3. 3Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia
  4. 4Animal Science, AgResearch Limited, Palmerston North, New Zealand
  5. 5Dept of Applied Physics, Sciences Faculty, University of Granada, Granada, Spain
  6. 6Dept of Medicine, Monash University, The Alfred Hospital, Melbourne, Australia
  7. 7Cystic Fibrosis Service, The Alfred Hospital, Melbourne, Australia
  8. 8The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia
  9. 9Dept of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA
  10. 10Monash Biomedicine Discovery Institute, Dept of Microbiology, Monash University, Clayton, Australia
  11. 11These two authors contributed equally to this work
  1. Tony Velkov, Dept of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Victoria 3010, Australia. E-mail: tony.velkov{at}unimelb.edu.au
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Funding

  • National Institute of Allergy and Infectious Diseases

    R01 AI111965
  • American Society for Microbiology

  • National Health and Medical Research Council

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The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites
Elena K. Schneider, Rachel M. McQuade, Vincenzo C. Carbone, Felisa Reyes-Ortega, John W. Wilson, Brenda Button, Ayame Saito, Daniel P. Poole, Daniel Hoyer, Jian Li, Tony Velkov
ERJ Open Research Jan 2018, 4 (1) 00127-2017; DOI: 10.1183/23120541.00127-2017

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The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites
Elena K. Schneider, Rachel M. McQuade, Vincenzo C. Carbone, Felisa Reyes-Ortega, John W. Wilson, Brenda Button, Ayame Saito, Daniel P. Poole, Daniel Hoyer, Jian Li, Tony Velkov
ERJ Open Research Jan 2018, 4 (1) 00127-2017; DOI: 10.1183/23120541.00127-2017
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