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Noninvasive ventilation in stable hypercapnic COPD: what is the evidence?

Marieke L. Duiverman
ERJ Open Research 2018 4: 00012-2018; DOI: 10.1183/23120541.00012-2018
Marieke L. Duiverman
1Dept of Pulmonary Diseases/Home Mechanical Ventilation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
2Groningen Research Institute of Asthma and COPD, University of Groningen, Groningen, The Netherlands
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  • For correspondence: m.l.duiverman@umcg.nl
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    FIGURE 1

    Evolution of ventilatory settings in randomised controlled trials investigating noninvasive ventilation in stable or post-exacerbation chronic obstructive pulmonary disease. IPAP: inspiratory airway pressure; EPAP: expiratory airway pressure; BURR: back-up respiratory rate.

  • FIGURE 2
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    FIGURE 2

    Forced expiratory volume in 1 s (FEV1) results in the RECOVER trial. FEV1 was measured at different points for the noninvasive intermittent positive pressure ventilation (NIPPV) + rehabilitation group (red triangles) and the rehabilitation group (blue squares). The change was significantly better in the NIPPV + rehabilitation group (p<0.02). Reproduced from [33] with permission from the publisher.

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    FIGURE 3

    The influence of noninvasive ventilation (NIV) on the delicate balance between increased load and decreased capacity of the respiratory system in severe chronic obstructive pulmonary disease (COPD). The radiography image is reproduced from Radiology Assistant (www.radiologyassistant.nl) with permission.

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Vol 4 Issue 2 Table of Contents
ERJ Open Research: 4 (2)
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Noninvasive ventilation in stable hypercapnic COPD: what is the evidence?
Marieke L. Duiverman
ERJ Open Research Apr 2018, 4 (2) 00012-2018; DOI: 10.1183/23120541.00012-2018

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Noninvasive ventilation in stable hypercapnic COPD: what is the evidence?
Marieke L. Duiverman
ERJ Open Research Apr 2018, 4 (2) 00012-2018; DOI: 10.1183/23120541.00012-2018
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  • Article
    • Abstract
    • Abstract
    • Introduction
    • The history of high-intensity noninvasive ventilation
    • Randomised controlled trials using high-intensity noninvasive ventilation
    • Challenges in noninvasive ventilation
    • Conclusions
    • Acknowledgements
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    • References
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