Skip to main content

Main menu

  • Home
  • Current issue
  • Early View
  • Archive
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • COVID-19 submission information
    • Institutional open access agreements
    • Peer reviewer login
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • Early View
  • Archive
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • COVID-19 submission information
    • Institutional open access agreements
    • Peer reviewer login
  • Alerts
  • Subscriptions

Effect of intermittent inspiratory leaks on measurement of lung clearance index using nitrogen and sulfur hexafluoride

Florian Singer, Kathryn Ramsey, Philipp Latzin
ERJ Open Research 2018 4: 00140-2018; DOI: 10.1183/23120541.00140-2018
Florian Singer
Division of Respiratory Medicine, Dept of Paediatrics, University Hospital of Bern, University of Bern, Bern, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Florian Singer
Kathryn Ramsey
Division of Respiratory Medicine, Dept of Paediatrics, University Hospital of Bern, University of Bern, Bern, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Kathryn Ramsey
Philipp Latzin
Division of Respiratory Medicine, Dept of Paediatrics, University Hospital of Bern, University of Bern, Bern, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Philipp Latzin
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Nitrogen MBW is susceptible to leaks; effects of leaks on sulfur hexafluoride MBW require further study http://ow.ly/iY6o30lGchV

From the authors:

We thank C.A. Whitfield and colleagues for their interest in our study [1], and agree that the effects of leaks on multiple-breath washout (MBW) outcomes are dependent on the type of tracer gas. Efforts should be made to develop an online feedback to inform operators of the tightness or leakiness of the system [2].

We used in vivo data to model leaks. The assumption of even mixing of leaked gas may be regarded as a limitation of our study. We, however, do not assume that modelled leaks in our study would be easily visible during testing. Figure 3a [1], for example, displays traces during a temporary leak across two tidal breaths that cannot be easily identified. The current mathematical lung model described by C.A. Whitfield and colleagues assumes a simple, symmetrically branching, trumpet airway. The interpretation is limited, as the data from the lung model seem preliminary [3]. It remains unclear if the model accounts for uneven gas mixing and validation in vivo is required. Taken together, MBW using nitrogen is susceptible to leaks. Data on the effects on leaks on MBW using sulfur hexafluoride are inconclusive so far.

Footnotes

  • Conflict of interest: None declared.

  • Received August 28, 2018.
  • Accepted August 28, 2018.
  • Copyright ©ERS 2018

This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

References

  1. ↵
    1. Lenherr N,
    2. Ramsey KA,
    3. Jost K, et al.
    Leaks during multiple-breath washout: characterisation and influence on outcomes. ERJ Open Res 2018; 4: 00012-2017.
    OpenUrl
  2. ↵
    1. Robinson PD,
    2. Latzin P,
    3. Verbanck S, et al.
    Consensus statement for inert gas washout measurement using multiple- and single-breath tests. Eur Respir J 2013; 41: 507–522.
    OpenUrlAbstract/FREE Full Text
  3. ↵
    1. Whitfield CA,
    2. Horsley A,
    3. Jensen OE
    . Modelling structural determinants of ventilation heterogeneity: a perturbative approach. bioRxiv 2018; 329961.
PreviousNext
Back to top
Vol 4 Issue 4 Table of Contents
ERJ Open Research: 4 (4)
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Effect of intermittent inspiratory leaks on measurement of lung clearance index using nitrogen and sulfur hexafluoride
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
Citation Tools
Effect of intermittent inspiratory leaks on measurement of lung clearance index using nitrogen and sulfur hexafluoride
Florian Singer, Kathryn Ramsey, Philipp Latzin
ERJ Open Research Oct 2018, 4 (4) 00140-2018; DOI: 10.1183/23120541.00140-2018

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Effect of intermittent inspiratory leaks on measurement of lung clearance index using nitrogen and sulfur hexafluoride
Florian Singer, Kathryn Ramsey, Philipp Latzin
ERJ Open Research Oct 2018, 4 (4) 00140-2018; DOI: 10.1183/23120541.00140-2018
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
    • Abstract
    • Footnotes
    • References
  • Info & Metrics
  • PDF

Subjects

  • CF and non-CF bronchiectasis
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Nanopore-based metagenomic sequencing
  • Lung cancer with comorbid interstitial pneumonia
  • Lung cancer with comorbid interstitial pneumonia
Show more Correspondence

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About ERJ Open Research

  • Editorial board
  • Journal information
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Online ISSN: 2312-0541

Copyright © 2023 by the European Respiratory Society