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Impact of a protocol-driven unified service for neonates with bronchopulmonary dysplasia

Natalie Batey, Dushyant Batra, Jon Dorling, Jayesh Mahendra Bhatt
ERJ Open Research 2019 5: 00183-2018; DOI: 10.1183/23120541.00183-2018
Natalie Batey
1Nottingham Neonatal Service, Nottingham University Hospitals NHS Trust, Nottingham, UK
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Dushyant Batra
1Nottingham Neonatal Service, Nottingham University Hospitals NHS Trust, Nottingham, UK
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Jon Dorling
1Nottingham Neonatal Service, Nottingham University Hospitals NHS Trust, Nottingham, UK
2Dept of Academic Child Health, University of Nottingham, Nottingham, UK
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Jayesh Mahendra Bhatt
3Paediatric Respiratory Dept, Nottingham Children's Hospital, Nottingham University Hospitals NHS Trust, Nottingham, UK
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  • For correspondence: jayesh.bhatt@nuh.nhs.uk
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Tables

  • TABLE 1

    Comparison of demographic details of the two cohorts, 2004–2006 and 2008–2010

    2004–20062008–2010p-value
    Subjects1644
    Birthweight g720 (480–1000)755 (410–1300)0.564#
    Gestation weeks25 (23–29)26 (23–29)0.358#
    Male10 (62.5)23 (52.3)0.481¶

    Data are presented as n, median (range) or n (%), unless otherwise stated. #: Mann–Whitney U-test; ¶: Chi-squared.

    • TABLE 2

      Comparison of outcomes between the two cohorts, 2004–2006 and 2008–2010

      2004–20062008–2010p-value
      Time in oxygen months#15 (0–66)5 (2–24)0.01
      Total hospital readmissions1 (0–17)1 (0–5)0.365
      Total respiratory-related readmissions1 (0–8)1 (0–5)0.948
      Length of respiratory admissions days4.5 (0–263)5 (0–105)0.717
      Total emergency department attendances0 (0–1)1 (0–6)0.05

      Data are presented as median (range), unless otherwise stated. #: one infant in each group had insufficient data on the length of time in long-term oxygen therapy, so were excluded from analysis.

      • TABLE 3

        Statistics of last oximetry study prior to discontinuing oxygen

        SpO2%96 (95–97.5)
        Minimum SpO2%93
        Drops of ≥4% per hour3.8 (2.2–5.3)
        Percentage of total study time with SpO2 <90%0.56 (0.19–0.94)
        SpO2 <90%2 min 29 s (1 min 14 s to 5 min 15 s)

        Data are presented as median (interquartile range), unless otherwise stated. SpO2: arterial oxygen saturation measured by pulse oximetry.

        • TABLE 4

          Comparison of duration of home oxygen therapy

          First author [ref.]Cases nFlow rates L·min−1Saturation targetDuration months
          Saletti [9]930.06 (0.03–0.5)92–98%Daytime 1 (0–13); night-time 2 (0–13)
          Hudak [17]300.125–0.5≥95%4.5 (0.5–17)
          Bertrand [18]20NANA5.7±3#
          Silva [19]560.125 (0.03–0.85)
          5% in >0.3
          ≥95%Daytime 3 (1–23.5); night-time 5 (1–28.5)
          Norzila [20]32NA≥94%3.5 (3–6)¶
          Oliveira [21]46NA≥93%11 (4–51)
          Yeh [22]154≤0.125–≥0.5
          11% in ≥0.5
          NA7.6 (6–9.3)
          The present study440.08–1.5≥93%5 (2–24)

          Data are presented as n or median (range), unless otherwise stated. NA: not available. #: mean±sd; ¶: median (interquartile range).

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          Impact of a protocol-driven unified service for neonates with bronchopulmonary dysplasia
          Natalie Batey, Dushyant Batra, Jon Dorling, Jayesh Mahendra Bhatt
          ERJ Open Research Feb 2019, 5 (1) 00183-2018; DOI: 10.1183/23120541.00183-2018

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          Impact of a protocol-driven unified service for neonates with bronchopulmonary dysplasia
          Natalie Batey, Dushyant Batra, Jon Dorling, Jayesh Mahendra Bhatt
          ERJ Open Research Feb 2019, 5 (1) 00183-2018; DOI: 10.1183/23120541.00183-2018
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