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Table of Contents

01 April 2019; volume 5, issue 2

Editorial

  • Open Access
    Advancing preparedness for clinical research during infectious disease epidemics
    Nina Gobat, John Amuasi, Yazdan Yazdanpanah, Louise Sigfid, Hugh Davies, John-Paul Byrne, Gail Carson, Christopher Butler, Alistair Nichol, Herman Goossens
    ERJ Open Res 5: 00227-2018; DOI: 10.1183/23120541.00227-2018 Published 20 May 2019

Review

  • Open Access
    Spirometric indices in primary ciliary dyskinesia: systematic review and meta-analysis
    Florian S. Halbeisen, Anu Jose, Carmen de Jong, Sylvia Nyilas, Philipp Latzin, Claudia E. Kuehni, Myrofora Goutaki
    ERJ Open Res 5: 00231-2018; DOI: 10.1183/23120541.00231-2018 Published 13 May 2019

Congress Highlights

  • Open Access
    From the pathophysiology of the human lung alveolus to epigenetic editing: Congress 2018 highlights from ERS Assembly 3 “Basic and Translational Science.”
    Marko Z. Nikolić, Eva M. Garrido-Martin, Flavia R. Greiffo, Aurélie Fabre, Irene H. Heijink, Agnes Boots, Catherine M. Greene, Pieter S. Hiemstra, Sabine Bartel
    ERJ Open Res 5: 00194-2018; DOI: 10.1183/23120541.00194-2018 Published 13 May 2019
  • Open Access
    Key paediatric messages from the 2018 European Respiratory Society International Congress
    Raffaella Nenna, Katie A. Hunt, Theodore Dassios, Jennifer J.P. Collins, Robbert J. Rottier, Norrice M. Liu, Bart Rottier, Myrofora Goutaki, Bülent Karadag, Andrew Prayle, Ricardo M. Fernandes, Giuseppe Fabio Parisi, Jürg Barben, Bruna Rubbo, Deborah Snijders, Heidi Makrinioti, Graham Hall, Mariëlle W. Pijnenburg, Jonathan Grigg
    ERJ Open Res 5: 00241-2018; DOI: 10.1183/23120541.00241-2018 Published 29 April 2019
  • Open Access
    Highlights of thoracic oncology from the 2018 ERS International Congress
    Polyxeni Ntontsi, Clementine Bostantzoglou, Torsten Gerriet Blum
    ERJ Open Res 5: 00222-2018; DOI: 10.1183/23120541.00222-2018 Published 17 June 2019

Original articles

  • Exercise

    • Open Access
      Peak oxygen uptake reference values for cycle ergometry for the healthy Dutch population: data from the LowLands Fitness Registry
      Caspar Frederik Mylius, Wilhelmus Petrus Krijnen, Cornelis Peter van der Schans, Tim Takken
      ERJ Open Res 5: 00056-2018; DOI: 10.1183/23120541.00056-2018 Published 1 April 2019
  • Interstitial lung disease

    • Open Access
      The characterisation of interstitial lung disease multidisciplinary team meetings: a global study
      Luca Richeldi, Naomi Launders, Fernando Martinez, Simon L.F. Walsh, Jeffrey Myers, Bonnie Wang, Mark Jones, Alison Chisholm, Kevin R. Flaherty
      ERJ Open Res 5: 00209-2018; DOI: 10.1183/23120541.00209-2018 Published 1 April 2019
    • Open Access
      Long-term evaluation of home-based pulmonary rehabilitation in patients with fibrotic idiopathic interstitial pneumonias
      Benoit Wallaert, Louise Duthoit, Elodie Drumez, Hélène Behal, Lidwine Wemeau, Cécile Chenivesse, Jean-Marie Grosbois
      ERJ Open Res 5: 00045-2019; DOI: 10.1183/23120541.00045-2019 Published 8 April 2019
    • Open Access
      Effects of nintedanib in patients with idiopathic pulmonary fibrosis by GAP stage
      Christopher J. Ryerson, Martin Kolb, Luca Richeldi, Joyce Lee, Daniel Wachtlin, Susanne Stowasser, Venerino Poletti
      ERJ Open Res 5: 00127-2018; DOI: 10.1183/23120541.00127-2018 Published 29 April 2019
    • Open Access
      Communication difficulties reported by patients diagnosed with idiopathic pulmonary fibrosis and their carers: a European focus group study
      Sarah Masefield, Nicola Cassidy, Derek Ross, Pippa Powell, Athol Wells
      ERJ Open Res 5: 00055-2019; DOI: 10.1183/23120541.00055-2019 Published 4 June 2019
    • Open Access
      Novel idiopathic pulmonary fibrosis susceptibility variants revealed by deep sequencing
      Jose M. Lorenzo-Salazar, Shwu-Fan Ma, Jonathan Jou, Pei-Chi Hou, Beatriz Guillen-Guio, Richard J. Allen, R. Gisli Jenkins, Louise V. Wain, Justin M. Oldham, Imre Noth, Carlos Flores
      ERJ Open Res 5: 00071-2019; DOI: 10.1183/23120541.00071-2019 Published 10 June 2019
  • Critical care

    • Open Access
      Volatile organic compound profiles in outlet air from extracorporeal life-support devices differ from breath profiles in critically ill patients
      Jan Hendrik Leopold, Alois Philipp, Thomas Bein, Andreas Redel, Michael Gruber, Marcus J. Schultz, Ameen Abu-Hanna, Paul Brinkman, Hans-Gerd Janssen, Lieuwe D.J. Bos
      ERJ Open Res 5: 00134-2018; DOI: 10.1183/23120541.00134-2018 Published 1 April 2019
  • Pulmonary therapeutics

    • Open Access
      Nebulised lipid–polymer hybrid nanoparticles for the delivery of a therapeutic anti-inflammatory microRNA to bronchial epithelial cells
      Sebastian Vencken, Camilla Foged, Joanne M. Ramsey, Louise Sweeney, Sally-Ann Cryan, Ronan J. MacLoughlin, Catherine M. Greene
      ERJ Open Res 5: 00161-2018; DOI: 10.1183/23120541.00161-2018 Published 8 April 2019
  • Pulmonary vascular disease

    • Open Access
      A retrospective analysis of outcomes in low- and intermediate–high-risk pulmonary embolism patients managed on an ambulatory medical unit in the UK
      Michael E. Reschen, Jonathan Raby, Jordan Bowen, Sudhir Singh, Daniel Lasserson, Christopher A. O'Callaghan
      ERJ Open Res 5: 00184-2018; DOI: 10.1183/23120541.00184-2018 Published 8 April 2019
  • Nicotine and pregnancy

    • Open Access
      Stopping when knowing: use of snus and nicotine during pregnancy in Scandinavia
      Ina Kreyberg, Karen E.S. Bains, Kai-H. Carlsen, Berit Granum, Hrefna K. Gudmundsdóttir, Guttorm Haugen, Gunilla Hedlin, Katarina Hilde, Christine M. Jonassen, Live S. Nordhagen, Björn Nordlund, Katrine D. Sjøborg, Håvard O. Skjerven, Anne C. Staff, Cilla Söderhäll, Riyas M. Vettukatil, Karin C. Lødrup Carlsen
      ERJ Open Res 5: 00197-2018; DOI: 10.1183/23120541.00197-2018 Published 8 April 2019
  • Bronchoscopy

    • Open Access
      Evaluation of a re-useable bronchoscopy biosimulator with ventilated lungs
      Justin L. Garner, Stefan D. Garner, Robin J. Hardie, Philip L. Molyneaux, Suveer Singh, Samuel V. Kemp, Pallav L. Shah
      ERJ Open Res 5: 00035-2019; DOI: 10.1183/23120541.00035-2019 Published 15 April 2019
  • Tuberculosis

    • Open Access
      Association of anti-tuberculosis drug concentrations in hair and treatment outcomes in MDR- and XDR-TB
      John Metcalfe, Peter Bacchetti, Roy Gerona, Ali Esmail, Keertan Dheda, Monica Gandhi
      ERJ Open Res 5: 00046-2019; DOI: 10.1183/23120541.00046-2019 Published 26 April 2019
    • Open Access
      A new mathematical model to identify contacts with recent and remote latent tuberculosis
      Gabrielle Fröberg, Emilie Wahren Borgström, Erja Chryssanthou, Margarida Correia-Neves, Gunilla Källenius, Judith Bruchfeld
      ERJ Open Res 5: 00078-2019; DOI: 10.1183/23120541.00078-2019 Published 10 June 2019
  • COPD

    • Open Access
      Exploring the potential benefits of digital health technology for the management of COPD: a qualitative study of patient perceptions
      Patrick Slevin, Threase Kessie, John Cullen, Marcus W. Butler, Seamas C. Donnelly, Brian Caulfield
      ERJ Open Res 5: 00239-2018; DOI: 10.1183/23120541.00239-2018 Published 13 May 2019
    • Open Access
      Outcomes reported on the management of COPD exacerbations: a systematic survey of randomised controlled trials
      Alexander G. Mathioudakis, Mia Moberg, Julie Janner, Pablo Alonso-Coello, Jørgen Vestbo
      ERJ Open Res 5: 00072-2019; DOI: 10.1183/23120541.00072-2019 Published 13 May 2019
    • Open Access
      Memory, attention and fluency deficits in COPD may be a specific form of cognitive impairment
      Charlotte Morris, James W. Mitchell, Hannah Moorey, Helen-Cara Younan, George Tadros, Alice M. Turner
      ERJ Open Res 5: 00229-2018; DOI: 10.1183/23120541.00229-2018 Published 28 May 2019
    • Open Access
      Validity of the diagnosis of pneumonia in hospitalised patients with COPD
      Lydia J. Finney, Vijay Padmanaban, Samuel Todd, Nadia Ahmed, Sarah L. Elkin, Patrick Mallia
      ERJ Open Res 5: 00031-2019; DOI: 10.1183/23120541.00031-2019 Published 24 June 2019
  • Oxygen therapy

    • Open Access
      A telephone-based survey of current trends, habits and beliefs in patients receiving portable oxygen therapy in Madrid, Spain
      Sagrario Mayoralas Alises, Catia Caneiras, Salvador Díaz-Lobato
      ERJ Open Res 5: 00059-2018; DOI: 10.1183/23120541.00059-2018 Published 20 May 2019
  • Cough

    • Open Access
      Predictors of prolongation in recent-onset cough
      Anne M. Lätti, Juha Pekkanen, Heikki O. Koskela
      ERJ Open Res 5: 00238-2018; DOI: 10.1183/23120541.00238-2018 Published 28 May 2019
  • Lung cancer

    • Open Access
      High frequency of infection of lung cancer patients with the parasite Toxoplasma gondii
      Jaroslav Bajnok, Muyassar Tarabulsi, Helen Carlin, Kevin Bown, Thomas Southworth, Josiah Dungwa, Dave Singh, Zhao-Rong Lun, Lucy Smyth, Geoff Hide
      ERJ Open Res 5: 00143-2018; DOI: 10.1183/23120541.00143-2018 Published 28 May 2019
  • Sleep

    • Open Access
      Snoring and nocturnal reflux: association with lung function decline and respiratory symptoms
      Össur Ingi Emilsson, Shadi Amid Hägg, Eva Lindberg, Karl A. Franklin, Kjell Toren, Bryndis Benediktsdottir, Thor Aspelund, Francisco Gómez Real, Bénédicte Leynaert, Pascal Demoly, Torben Sigsgaard, Jennifer Perret, Andrei Malinovschi, Deborah Jarvis, Judith Garcia-Aymerich, Thorarinn Gislason, Christer Janson
      ERJ Open Res 5: 00010-2019; DOI: 10.1183/23120541.00010-2019 Published 28 May 2019
  • Respiratory infections

    • Open Access
      Amikacin exposure and susceptibility of macrolide-resistant Mycobacterium abscessus
      Shelby Daniel-Wayman, Shamira Shallom, Nabila Azeem, Kenneth N. Olivier, Adrian M. Zelazny, D. Rebecca Prevots
      ERJ Open Res 5: 00154-2018; DOI: 10.1183/23120541.00154-2018 Published 28 May 2019
  • Pneumothorax

    • Open Access
      Incidence of primary spontaneous pneumothorax: a validated, register-based nationwide study
      Winnie Hedevang Olesen, Ingrid Louise Titlestad, Poul Erik Andersen, Rune Lindahl-Jacobsen, Peter Bjørn Licht
      ERJ Open Res 5: 00022-2019; DOI: 10.1183/23120541.00022-2019 Published 10 June 2019
  • Cystic fibrosis

    • Open Access
      Clinical development of triple-combination CFTR modulators for cystic fibrosis patients with one or two F508del alleles
      Jennifer L. Taylor-Cousar, Marcus A. Mall, Bonnie W. Ramsey, Edward F. McKone, Elizabeth Tullis, Gautham Marigowda, Charlotte M. McKee, David Waltz, Samuel M. Moskowitz, Jessica Savage, Fengjuan Xuan, Steven M. Rowe
      ERJ Open Res 5: 00082-2019; DOI: 10.1183/23120541.00082-2019 Published 17 June 2019
  • Asthma

    • Open Access
      The long-term effect of an exercise and diet intervention in asthma patients: a 1-year follow-up on a randomised controlled trial
      Adrian Koch Bentzon, Linda Wolfgang Loehde, Vibeke Backer, Louise Toennesen
      ERJ Open Res 5: 00032-2019; DOI: 10.1183/23120541.00032-2019 Published 24 June 2019

Original research letters

  • Open Access
    Recruitment in online research for COPD: leveraging social media and research registries
    Samantha R. Paige, Janice L. Krieger
    ERJ Open Res 5: 00167-2018; DOI: 10.1183/23120541.00167-2018 Published 8 April 2019
  • Open Access
    External validation of the SAPS3-CNIV score to predict hospital mortality following noninvasive ventilation: a retrospective single-centre study
    Taha Huseini, David Manners, Simon Jones, Francesco Piccolo
    ERJ Open Res 5: 00232-2018; DOI: 10.1183/23120541.00232-2018 Published 8 April 2019
  • Open Access
    Impact of atrial septal defect closure on diffusing capacity for nitric oxide and carbon monoxide
    Martina Nassif, Reindert P. van Steenwijk, Ivo van der Lee, Peter J. Sterk, Frans H.C. de Jongh, Jacqueline M. Hogenhout, Jan G.P. Tijssen, Barbara J.M. Mulder, Robbert J. de Winter
    ERJ Open Res 5: 00260-2018; DOI: 10.1183/23120541.00260-2018 Published 8 April 2019
  • Open Access
    Plasma microfibrillar-associated protein 4 is not prognostic of emphysema progression but is associated with cardiovascular disease history and mortality in COPD patients
    Sofie Lock Johansson, Helle Wulf-Johansson, Anders Schlosser, Ingrid L. Titlestad, Bruce Miller, Ruth Tal-Singer, Uffe Holmskov, Jørgen Vestbo, Grith Lykke Sørensen
    ERJ Open Res 5: 00021-2019; DOI: 10.1183/23120541.00021-2019 Published 15 April 2019
  • Open Access
    Seasonal variation in asthma exacerbations in the AUSTRI and VESTRI studies
    Stanley J. Szefler, Ibrahim Raphiou, Robert S. Zeiger, David Stempel, Kenneth Kral, Steven Pascoe
    ERJ Open Res 5: 00153-2018; DOI: 10.1183/23120541.00153-2018 Published 26 April 2019
  • Open Access
    Prolidase deficiency diagnosed by whole exome sequencing in a child with pulmonary capillaritis
    Jonathan H. Rayment, Rebekah Jobling, Sarah Bowdin, Ernest Cutz, Sharon D. Dell
    ERJ Open Res 5: 00205-2018; DOI: 10.1183/23120541.00205-2018 Published 26 April 2019
  • Open Access
    Prevalence of latent TB infection among asylum seekers in emergency accommodation in Cologne, Germany
    Florian Neuhann, Natalie Funke, Anne Bunte, Claudia Beiersmann
    ERJ Open Res 5: 00067-2019; DOI: 10.1183/23120541.00067-2019 Published 29 April 2019
  • Open Access
    Novel mouse model of indwelling pleural catheter in mice with malignant pleural effusion
    Christopher Merrick, Taylor Sherrill, Nikolaos I. Kanellakis, Rachelle Asciak, Georgios T. Stathopoulos, Fabien Maldonado, Najib M. Rahman, Timothy Blackwell, Ioannis Psallidas
    ERJ Open Res 5: 00226-2018; DOI: 10.1183/23120541.00226-2018 Published 28 May 2019
  • Open Access
    The superexacerbator phenotype in patients with COPD: a descriptive analysis
    Lowie E.G.W. Vanfleteren, Lotte M.C. Boonen, Martijn A. Spruit, Daisy J.A. Janssen, Emiel F.M. Wouters, Frits M.E. Franssen
    ERJ Open Res 5: 00235-2018; DOI: 10.1183/23120541.00235-2018 Published 4 June 2019
  • Open Access
    A home-based lower limb-specific resistance training programme for patients with COPD: an explorative feasibility study
    Hannah Cook, Charles C. Reilly, Gerrard F. Rafferty
    ERJ Open Res 5: 00126-2018; DOI: 10.1183/23120541.00126-2018 Published 10 June 2019
  • Open Access
    Cystic fibrosis disease severity correlates with plasma levels of desmosine and isodesmosine, biomarkers of elastin degradation
    Shuren Ma, Patrick Geraghty, Abdoulaye Dabo, Cormac McCarthy, N. Gerry McElvaney, Gerard M. Turino
    ERJ Open Res 5: 00250-2018; DOI: 10.1183/23120541.00250-2018 Published 17 June 2019
  • Open Access
    Airway obstruction is associated with reduced variability in specific parts of the tidal breathing flow–volume curve in young children
    Ville-Pekka Seppä, Anton Hult, Javier Gracia-Tabuenca, Marita Paassilta, Jari Viik, Davor Plavec, Jussi Karjalainen
    ERJ Open Res 5: 00028-2019; DOI: 10.1183/23120541.00028-2019 Published 17 June 2019
  • Open Access
    Does oxygen pulse trajectory during incremental exercise discriminate impaired oxygen delivery from poor muscle oxygen utilisation?
    Luiza H. Degani-Costa, Luiz E. Nery, Maíra T. Rodrigues, Ana Cristina Gimenes, Eloara V. Ferreira, Jaquelina S. Ota-Arakaki, J. Alberto Neder, Roberta P. Ramos
    ERJ Open Res 5: 00108-2018; DOI: 10.1183/23120541.00108-2018 Published 24 June 2019
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