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Nebulised lipid–polymer hybrid nanoparticles for the delivery of a therapeutic anti-inflammatory microRNA to bronchial epithelial cells

Sebastian Vencken, Camilla Foged, Joanne M. Ramsey, Louise Sweeney, Sally-Ann Cryan, Ronan J. MacLoughlin, Catherine M. Greene
ERJ Open Research 2019 5: 00161-2018; DOI: 10.1183/23120541.00161-2018
Sebastian Vencken
1Lung Biology Group, Dept of Clinical Microbiology, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
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Camilla Foged
2Dept of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Joanne M. Ramsey
3Drug Delivery and Advanced Materials Team and Tissue Engineering Research Group, School of Pharmacy and Dept of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland
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Louise Sweeney
4Aerogen Ltd, Galway, Ireland
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Sally-Ann Cryan
3Drug Delivery and Advanced Materials Team and Tissue Engineering Research Group, School of Pharmacy and Dept of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland
5Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Ireland
6SFI Centre for Research in Medical Devices (CURAM), Royal College of Surgeons in Ireland, Dublin and NUI Galway, Galway, Ireland
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Ronan J. MacLoughlin
4Aerogen Ltd, Galway, Ireland
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Catherine M. Greene
1Lung Biology Group, Dept of Clinical Microbiology, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
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  • For correspondence: cmgreene@rcsi.ie
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Article Information

vol. 5 no. 2
DOI 
https://doi.org/10.1183/23120541.00161-2018

Published By 
European Respiratory Society
Online ISSN 
2312-0541
History 
  • Received September 14, 2018
  • Accepted February 19, 2019
  • Published online April 8, 2019.

Copyright & Usage 
Copyright ©ERS 2019 This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

Author Information

  1. Sebastian Vencken1,
  2. Camilla Foged2,
  3. Joanne M. Ramsey3,
  4. Louise Sweeney4,
  5. Sally-Ann Cryan3,5,6,
  6. Ronan J. MacLoughlin4 and
  7. Catherine M. Greene1⇑
  1. 1Lung Biology Group, Dept of Clinical Microbiology, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
  2. 2Dept of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  3. 3Drug Delivery and Advanced Materials Team and Tissue Engineering Research Group, School of Pharmacy and Dept of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland
  4. 4Aerogen Ltd, Galway, Ireland
  5. 5Trinity Centre for Bioengineering, Trinity College Dublin, Dublin, Ireland
  6. 6SFI Centre for Research in Medical Devices (CURAM), Royal College of Surgeons in Ireland, Dublin and NUI Galway, Galway, Ireland
  1. Catherine M. Greene, Lung Biology Group, Dept of Clinical Microbiology, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland. E-mail: cmgreene{at}rcsi.ie
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Funding

  • Cystic Fibrosis Foundation Therapeutics

    GREENE15XXO
  • National Children's Research Centre

    C/13/1
  • Science Foundation Ireland

    13/IA/1840

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Vol 5 Issue 2 Table of Contents
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Nebulised lipid–polymer hybrid nanoparticles for the delivery of a therapeutic anti-inflammatory microRNA to bronchial epithelial cells
Sebastian Vencken, Camilla Foged, Joanne M. Ramsey, Louise Sweeney, Sally-Ann Cryan, Ronan J. MacLoughlin, Catherine M. Greene
ERJ Open Research Apr 2019, 5 (2) 00161-2018; DOI: 10.1183/23120541.00161-2018

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Nebulised lipid–polymer hybrid nanoparticles for the delivery of a therapeutic anti-inflammatory microRNA to bronchial epithelial cells
Sebastian Vencken, Camilla Foged, Joanne M. Ramsey, Louise Sweeney, Sally-Ann Cryan, Ronan J. MacLoughlin, Catherine M. Greene
ERJ Open Research Apr 2019, 5 (2) 00161-2018; DOI: 10.1183/23120541.00161-2018
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Subjects

  • Lung biology and experimental studies
  • Pulmonary pharmacology and therapeutics
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