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Cholinergic synapse pathway gene polymorphisms associated with allergen-induced late asthmatic responses

Ashwini Rajasekaran, Daniel He, Alice Yue, Amrit Singh, Casey P. Shannon, J. Mark FitzGerald, Louis-Philippe Boulet, Paul M. O'Byrne, Gail M. Gauvreau, Scott J. Tebbutt
ERJ Open Research 2019 5: 00107-2019; DOI: 10.1183/23120541.00107-2019
Ashwini Rajasekaran
1Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada
2Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, BC, Canada
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Daniel He
1Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada
2Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, BC, Canada
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  • ORCID record for Daniel He
Alice Yue
2Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, BC, Canada
3School of Computing Science, Simon Fraser University, Burnaby, BC, Canada
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Amrit Singh
1Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada
2Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, BC, Canada
4Dept of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
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Casey P. Shannon
1Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada
2Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, BC, Canada
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  • ORCID record for Casey P. Shannon
J. Mark FitzGerald
5Vancouver Coastal Health Research Institute, Vancouver General Hospital, Vancouver, BC, Canada
6Dept of Medicine, Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada
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Louis-Philippe Boulet
7Québec Heart and Lung Institute, Laval University, Québec City, QC, Canada
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Paul M. O'Byrne
8Dept of Medicine, McMaster University, Hamilton, ON, Canada
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Gail M. Gauvreau
8Dept of Medicine, McMaster University, Hamilton, ON, Canada
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Scott J. Tebbutt
1Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada
2Prevention of Organ Failure (PROOF) Centre of Excellence, Vancouver, BC, Canada
6Dept of Medicine, Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada
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  • ORCID record for Scott J. Tebbutt
  • For correspondence: Scott.Tebbutt@hli.ubc.ca
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    FIGURE 1

    a) Minor allele distribution and b) mean differences in the weighted cumulative minor allele content (w-cMAC) between early responders (ERs) and dual responders (DRs). Error bars represent 95% confidence intervals.

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Cholinergic synapse pathway gene polymorphisms associated with allergen-induced late asthmatic responses
Ashwini Rajasekaran, Daniel He, Alice Yue, Amrit Singh, Casey P. Shannon, J. Mark FitzGerald, Louis-Philippe Boulet, Paul M. O'Byrne, Gail M. Gauvreau, Scott J. Tebbutt
ERJ Open Research Oct 2019, 5 (4) 00107-2019; DOI: 10.1183/23120541.00107-2019

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Cholinergic synapse pathway gene polymorphisms associated with allergen-induced late asthmatic responses
Ashwini Rajasekaran, Daniel He, Alice Yue, Amrit Singh, Casey P. Shannon, J. Mark FitzGerald, Louis-Philippe Boulet, Paul M. O'Byrne, Gail M. Gauvreau, Scott J. Tebbutt
ERJ Open Research Oct 2019, 5 (4) 00107-2019; DOI: 10.1183/23120541.00107-2019
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