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miR-200 family members reduce senescence and restore idiopathic pulmonary fibrosis type II alveolar epithelial cell transdifferentiation

Silvia Moimas, Francesco Salton, Beata Kosmider, Nadja Ring, Maria C. Volpe, Karim Bahmed, Luca Braga, Michael Rehman, Simone Vodret, Maria Laura Graziani, Marla R. Wolfson, Nathaniel Marchetti, Thomas J. Rogers, Mauro Giacca, Gerard J. Criner, Serena Zacchigna, Marco Confalonieri
ERJ Open Research 2019 5: 00138-2019; DOI: 10.1183/23120541.00138-2019
Silvia Moimas
1Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy
9These authors contributed equally to this work (co-first authors)
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Francesco Salton
2Pulmonology Dept, University Hospital of Cattinara, Trieste, Italy
9These authors contributed equally to this work (co-first authors)
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Beata Kosmider
3Center for Inflammation, Translational and Clinical Lung Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA
4Dept of Thoracic Medicine and Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA
5Dept of Physiology, Temple University, Philadelphia, PA, USA
9These authors contributed equally to this work (co-first authors)
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Nadja Ring
6Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy
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Maria C. Volpe
2Pulmonology Dept, University Hospital of Cattinara, Trieste, Italy
7Dept of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy
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  • ORCID record for Maria C. Volpe
Karim Bahmed
3Center for Inflammation, Translational and Clinical Lung Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA
4Dept of Thoracic Medicine and Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA
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Luca Braga
1Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy
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Michael Rehman
6Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy
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  • ORCID record for Michael Rehman
Simone Vodret
6Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy
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Maria Laura Graziani
2Pulmonology Dept, University Hospital of Cattinara, Trieste, Italy
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Marla R. Wolfson
3Center for Inflammation, Translational and Clinical Lung Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA
4Dept of Thoracic Medicine and Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA
5Dept of Physiology, Temple University, Philadelphia, PA, USA
8CENTRe: Collaborative for Environmental and Neonatal Therapeutics, Katz School of Medicine at Temple University, Philadelphia, PA, USA
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Nathaniel Marchetti
4Dept of Thoracic Medicine and Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA
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Thomas J. Rogers
3Center for Inflammation, Translational and Clinical Lung Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA
4Dept of Thoracic Medicine and Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA
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Mauro Giacca
1Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy
7Dept of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy
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Gerard J. Criner
4Dept of Thoracic Medicine and Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA
10These authors contributed equally to this work (co-last authors)
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Serena Zacchigna
6Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy
7Dept of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy
10These authors contributed equally to this work (co-last authors)
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Marco Confalonieri
2Pulmonology Dept, University Hospital of Cattinara, Trieste, Italy
7Dept of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy
10These authors contributed equally to this work (co-last authors)
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  • For correspondence: mconfalonieri@units.it
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Article Information

vol. 5 no. 4
DOI 
https://doi.org/10.1183/23120541.00138-2019

Published By 
European Respiratory Society
Online ISSN 
2312-0541
History 
  • Received June 5, 2019
  • Accepted September 23, 2019
  • Published online December 16, 2019.

Copyright & Usage 
Copyright ©ERS 2019 This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

Author Information

  1. Silvia Moimas1,9,
  2. Francesco Salton2,9,
  3. Beata Kosmider3,4,5,9,
  4. Nadja Ring6,
  5. Maria C. Volpe2,7,
  6. Karim Bahmed3,4,
  7. Luca Braga1,
  8. Michael Rehman6,
  9. Simone Vodret6,
  10. Maria Laura Graziani2,
  11. Marla R. Wolfson3,4,5,8,
  12. Nathaniel Marchetti4,
  13. Thomas J. Rogers3,4,
  14. Mauro Giacca1,7,
  15. Gerard J. Criner4,10,
  16. Serena Zacchigna6,7,10 and
  17. Marco Confalonieri2,7,10⇑
  1. 1Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy
  2. 2Pulmonology Dept, University Hospital of Cattinara, Trieste, Italy
  3. 3Center for Inflammation, Translational and Clinical Lung Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA
  4. 4Dept of Thoracic Medicine and Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA
  5. 5Dept of Physiology, Temple University, Philadelphia, PA, USA
  6. 6Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy
  7. 7Dept of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy
  8. 8CENTRe: Collaborative for Environmental and Neonatal Therapeutics, Katz School of Medicine at Temple University, Philadelphia, PA, USA
  9. 9These authors contributed equally to this work (co-first authors)
  10. 10These authors contributed equally to this work (co-last authors)
  1. Marco Confalonieri, Pulmonology Dept, University of Trieste, Ospedale di Cattinara, Strada di Fiume 447, Trieste 34149, Italy. E-mail: mconfalonieri{at}units.it
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Funding

  • National Institutes of Health

    R01 HL118171
  • Fondazione CRT

    2016.0045

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miR-200 family members reduce senescence and restore idiopathic pulmonary fibrosis type II alveolar epithelial cell transdifferentiation
Silvia Moimas, Francesco Salton, Beata Kosmider, Nadja Ring, Maria C. Volpe, Karim Bahmed, Luca Braga, Michael Rehman, Simone Vodret, Maria Laura Graziani, Marla R. Wolfson, Nathaniel Marchetti, Thomas J. Rogers, Mauro Giacca, Gerard J. Criner, Serena Zacchigna, Marco Confalonieri
ERJ Open Research Oct 2019, 5 (4) 00138-2019; DOI: 10.1183/23120541.00138-2019

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miR-200 family members reduce senescence and restore idiopathic pulmonary fibrosis type II alveolar epithelial cell transdifferentiation
Silvia Moimas, Francesco Salton, Beata Kosmider, Nadja Ring, Maria C. Volpe, Karim Bahmed, Luca Braga, Michael Rehman, Simone Vodret, Maria Laura Graziani, Marla R. Wolfson, Nathaniel Marchetti, Thomas J. Rogers, Mauro Giacca, Gerard J. Criner, Serena Zacchigna, Marco Confalonieri
ERJ Open Research Oct 2019, 5 (4) 00138-2019; DOI: 10.1183/23120541.00138-2019
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