Figures
- FIGURE 1
Forced expiratory volume in the first second (FEV1) and forced expiratory flow at 25–75% of forced vital capacity (FEF25–75%) values as % best from baseline, against lung clearance index (LCI).
- FIGURE 2
Lung clearance index (LCI) against International Society for Heart and Lung Transplantation (ISHLT) bronchiolitis obliterans syndrome (BOS) grade. Bars represent group mean and standard deviation. p-values represent unpaired t-tests. Median LCI for BOS-2–3 was statistically higher than in all other groups (p<0.001, Mann–Whitney test).
- FIGURE 3
Lung clearance index (LCI) in patients with bronchiolitis obliterans syndrome (BOS) on high-resolution computed tomography (HRCT), no BOS on HRCT and those with no HRCT performed. Bars represent group mean and standard deviation. #: Mann–Whitney test; ¶: t-test.
- FIGURE 4
a) Ventilation heterogeneity of the conductive lung zone (Scond) and b) ventilation heterogeneity of the acinar lung zone (Sacin) against International Society for Heart and Lung Transplantation (ISHLT) bronchiolitis obliterans syndrome (BOS) grade. Bars represent group mean and standard deviation. For details of the statistical differences between groups, see table 1.
Tables
- TABLE 1
Summary of demographics and results across International Society for Heart and Lung Transplantation bronchiolitis obliterans syndrome (BOS) grades
Overall No BOS BOS-0p BOS-1 BOS-2–3 p-value Subjects 51 15 16 11 9 Age years 51.5±13.7 47.4±16.8 52.6±10.9 52.2±13.9 55.6±12.5 0.690§ Time since transplant years 4.0 (0.9–5.9) 1.0 (0.6–8.8) 4.1 (2.4–4.8) 3.6 (0.9–6.3) 5.0 (3.9–6.1) 0.735ƒ FEV1 % predicted 87 (68–95) 95 (94–97)*,#,¶ 90±4.7*,#,¶ 74±5.6*,¶,+ 56±8.2*,#,+ <0.0001ƒ LCI 8.8 (7.4–9.9) 7.6±0.84*,#,¶ 8.3±1.0*,#,¶ 9.3±1.0*,¶,+ 12.5 (10.8–14.1)*,#,+ <0.0001ƒ Scond 0.04 (0.02–0.07) 0.02±0.017*,#,¶ 0.04±0.03*,¶ 0.06±0.04+ 0.09±0.04+ <0.0001§ Sacin 0.24±0.13 0.19±0.08¶ 0.19±0.11¶ 0.23±0.06¶ 0.40±0.12*,#,+ <0.0001§ Data are presented as mean±sd or median (interquartile range), unless otherwise stated. For post hoc comparisons, unpaired t-tests were used where both cohorts were normally distributed (data expressed as mean±sd) or Mann–Whitney test for all others. FEV1: forced expiratory volume in the first second; LCI: lung clearance index; Scond: ventilation heterogeneity of the conductive lung zone; Sacin: ventilation heterogeneity of the acinar lung zone. *: p<0.05 versus BOS-0p, post hoc pairwise comparison; #: p<0.05 versus BOS-1, post hoc pairwise comparison; ¶: p<0.05 versus BOS-2–3, post hoc pairwise comparison; +: p<0.05 versus no BOS, post hoc pairwise comparison; §: ANOVA; ƒ: Kruskal–Wallis test.
Supplementary Material
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Supplementary material 00164-2019.SUPPLEMENT
