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Periconceptional folic acid supplementation and risk of parent-reported asthma in children at 4–6 years of age

Jufen Liu, Zhiwen Li, Rongwei Ye, Jianmeng Liu, Aiguo Ren
ERJ Open Research 2020 6: 00250-2019; DOI: 10.1183/23120541.00250-2019
Jufen Liu
1Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, PR China
2Dept of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, PR China
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  • ORCID record for Jufen Liu
Zhiwen Li
1Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, PR China
2Dept of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, PR China
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Rongwei Ye
1Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, PR China
2Dept of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, PR China
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Jianmeng Liu
1Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, PR China
2Dept of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, PR China
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Aiguo Ren
1Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, PR China
2Dept of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, PR China
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  • For correspondence: renag@bjmu.edu.cn
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Tables

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  • TABLE 1

    Characteristics of subjects and maternal folic acid supplementation, China, 1993–1995

    CharacteristicsFolic acid usersNon-usersp-value
    Subjects45424548
    Age at child birth years24.8±2.525.9±3.5<0.001
    Only child4104 (90.5)3545 (78.0)<0.001
    Education
     Senior high school or more1025 (24.5)1214 (28.6)<0.001
     Junior high school2325 (55.6)2012 (47.4)
     Primary school or less829 (19.8)1022 (24.1)
    Occupation
     Farmer1579 (34.8)1585 (34.9)0.001
     Factory worker1771 (39.0)1615 (35.5)
     Other or unknown1192 (26.2)1348 (29.6)
    Sex of infant
     Male2382 (52.4)2390 (52.6)0.919
     Female2160 (47.6)2158 (47.4)

    Data are presented as n, mean±sd or n (%), unless otherwise stated. Values for some characteristics may not be equal to total numbers in each group because of missing values.

    • TABLE 2

      Rate of allergic symptoms, asthma and hospitalisation due to asthma among offspring by maternal folic acid supplementation, China, 2000–2001

      Folic acidp-valueTotal
      YesNo
      Subjects454245489090
      Allergic symptoms70 (1.54)93 (2.04)0.070163 (1.79)
      Asthma42 (0.92)40 (0.88)0.82082 (0.90)
      Hospitalisation due to asthma11 (0.24)16 (0.35)0.33727 (0.30)

      Data are presented as n or n (%), unless otherwise stated.

      • TABLE 3

        Compliance of maternal folic acid supplementation and risk for allergic symptoms, asthma and hospitalisation due to asthma in offspring, 2000–2001 n (%)

        Folic acidCompliance#
        PericonceptionPreconceptionPostconceptionp ValueNot compliant (340)Compliant (3354)p Value
        Subjects236022911013403354
        Allergic symptoms28 (1.19)5 (2.18)18 (1.63)0.3843 (0.88)48 (1.43)0.443
        Asthma15 (0.64)1 (0.44)10 (0.91)0.7654 (1.18)22 (0.66)0.522
        Hospitalisation due to asthma4 (0.17)2 (0.87)10 (0.91)0.4790 (0)4 (0.12)0.565

        Data are presented as n or n (%), unless otherwise stated. Values for some characteristics may not be equal to total numbers in each group because of missing values. #: Compliance was calculated as actual consumed pills divided by expected pills, compliant refers to compliance >80% and not compliant refers to compliance <80%.

        • TABLE 4

          Odds ratio of allergic symptoms, asthma and hospitalisation due to asthma among offspring by maternal folic acid supplementation, China, 2000–2001

          DiseaseUnadjusted odds ratio (95% CI)Adjusted odds ratio (95% CI)#
          Allergic symptoms0.75 (0.55–1.03)0.80 (0.58–1.11)
          Asthma1.05 (0.68–1.63)1.04 (0.67–1.61)
          Hospitalisation due to asthma0.69 (0.32–1.48)0.79 (0.35–1.77)

          #: Adjusted by age, only-child, education and occupation.

          Supplementary Materials

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            Supplementary material 00250-2019.SUPPLEMENT

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          Periconceptional folic acid supplementation and risk of parent-reported asthma in children at 4–6 years of age
          Jufen Liu, Zhiwen Li, Rongwei Ye, Jianmeng Liu, Aiguo Ren
          ERJ Open Research Jan 2020, 6 (1) 00250-2019; DOI: 10.1183/23120541.00250-2019

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          Periconceptional folic acid supplementation and risk of parent-reported asthma in children at 4–6 years of age
          Jufen Liu, Zhiwen Li, Rongwei Ye, Jianmeng Liu, Aiguo Ren
          ERJ Open Research Jan 2020, 6 (1) 00250-2019; DOI: 10.1183/23120541.00250-2019
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