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Is pulmonary arterial hypertension associated with interferon-β therapy for multiple sclerosis reversible? A case study to explore the complexity

Anastasia Anthi, Eleni Stagaki, Loukianos Rallidis, Dimitrios Konstantonis, Maria-Eleftheria Evangelopoulos, Konstantinos Voumvourakis, Apostolos Armaganidis, Stylianos E. Orfanos
ERJ Open Research 2020 6: 00328-2019; DOI: 10.1183/23120541.00328-2019
Anastasia Anthi
1Pulmonary Hypertension Clinic, “Attikon” Hospital, Athens, Greece
22nd Dept of Critical Care, National and Kapodistrian University of Athens, “Attikon” Hospital, Athens, Greece
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  • For correspondence: anastasia.anthi1@gmail.com
Eleni Stagaki
1Pulmonary Hypertension Clinic, “Attikon” Hospital, Athens, Greece
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Loukianos Rallidis
1Pulmonary Hypertension Clinic, “Attikon” Hospital, Athens, Greece
32nd Dept of Cardiology, National and Kapodistrian University of Athens, “Attikon” Hospital, Athens, Greece
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Dimitrios Konstantonis
1Pulmonary Hypertension Clinic, “Attikon” Hospital, Athens, Greece
22nd Dept of Critical Care, National and Kapodistrian University of Athens, “Attikon” Hospital, Athens, Greece
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Maria-Eleftheria Evangelopoulos
4Demyelinating Diseases Unit, Dept of Neurology, National and Kapodistrian University of Athens, Eginition Hospital, Athens, Greece
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Konstantinos Voumvourakis
52nd Dept of Neurology, National and Kapodistrian University of Athens, “Attikon” Hospital, Athens, Greece
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Apostolos Armaganidis
1Pulmonary Hypertension Clinic, “Attikon” Hospital, Athens, Greece
22nd Dept of Critical Care, National and Kapodistrian University of Athens, “Attikon” Hospital, Athens, Greece
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  • ORCID record for Apostolos Armaganidis
Stylianos E. Orfanos
1Pulmonary Hypertension Clinic, “Attikon” Hospital, Athens, Greece
22nd Dept of Critical Care, National and Kapodistrian University of Athens, “Attikon” Hospital, Athens, Greece
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Tables

  • TABLE 1

    Functional status and right heart catheterisation at baseline, as well as 1 and 2 years after discontinuation of interferon-β and initiation of pulmonary arterial hypertension-specific therapy

    Baseline1 year2 years
    6MWT m 513502
    NYHA-FCIIIIIII
    RAP mmHg563
    PAP syst/diast/mean mmHg74/42/5349/21/3041/20/27
    PAWP mmHg1076
    CO L·min−13.36.56.3
    CI L·min−1·m−21.93.83.7
    PVR Wood units133.53.3

    Vasoreactivity testing during the first right heart catheterisation with intravenous epoprostenol up to 12 ng·kg−1·min−1 was negative. 6MWT: 6-min walking test; NYHA-FC: New York Heart Association functional class; RAP: right atrial pressure; PAP: pulmonary artery pressure; syst: systolic; diast: diastolic; PAWP: pulmonary artery wedge pressure; CO: cardiac output; CI: cardiac index; PVR: pulmonary vascular resistance.

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    Is pulmonary arterial hypertension associated with interferon-β therapy for multiple sclerosis reversible? A case study to explore the complexity
    Anastasia Anthi, Eleni Stagaki, Loukianos Rallidis, Dimitrios Konstantonis, Maria-Eleftheria Evangelopoulos, Konstantinos Voumvourakis, Apostolos Armaganidis, Stylianos E. Orfanos
    ERJ Open Research Jan 2020, 6 (1) 00328-2019; DOI: 10.1183/23120541.00328-2019

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    Is pulmonary arterial hypertension associated with interferon-β therapy for multiple sclerosis reversible? A case study to explore the complexity
    Anastasia Anthi, Eleni Stagaki, Loukianos Rallidis, Dimitrios Konstantonis, Maria-Eleftheria Evangelopoulos, Konstantinos Voumvourakis, Apostolos Armaganidis, Stylianos E. Orfanos
    ERJ Open Research Jan 2020, 6 (1) 00328-2019; DOI: 10.1183/23120541.00328-2019
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