Abstract
This study aimed to determine the health-related quality of life (HRQoL) of patients with pulmonary tuberculosis (TB) and to assess its change after a therapeutic surgical procedure. In this scenario, the purpose was to elucidate and quantify the effect of various demographic, epidemiological, clinical, surgical and psychosocial details on this variable.
A prospective cohort of 40 patients undergoing therapeutic surgery for pulmonary TB (Study of Human Tuberculosis Lesions (SH-TBL) cohort) was recruited in Tbilisi, Georgia, between 2016 and 2018. HRQoL was assessed by administering the St George's Respiratory Questionnaire (SGRQ) and a novel psychosocial questionnaire, the BCN-Q, both at baseline and at 6 months post-surgery.
A statistically and clinically significant improvement in the SGRQ total score was observed at follow-up, although it did not reach the values found for the healthy population. The differences between time points were statistically significant for the following groups: women, age <40 years, body mass index ≥20 kg·m−2, nonsmokers, drug-susceptible and drug-resistant participants, both new and relapsed patients, early culture negativisation, cases with a single lesion, either lesions <35 mm or ≥35 mm, and lesion, lobe and lung resections.
The analysis of BCN-Q together with the SGRQ showed that several of its items, such as marital status, living conditions, nutrition, employment, external support, certain attitudes towards the healthcare system, emotional burden and sleep troubles, can impact HRQoL.
These results highlight the benefit of adjuvant therapeutic surgery for pulmonary TB in selected patients in terms of HRQoL and suggest that a comprehensive approach including demographic, epidemiological, clinical and psychosocial variables may more accurately predict TB evolution and prognosis.
Abstract
Adjuvant therapeutic surgery in selected pulmonary TB patients improves their health-related quality of life. Impact of psychosocial variables on HRQoL may be assessed using a newly developed questionnaire, namely BCN-Q. https://bit.ly/2A169rR
Footnotes
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The work presented here is part of the SH-TBL (ClinicalTrials.gov: NCT02715271).
Conflict of interest: P. Benito has nothing to disclose.
Conflict of interest: S. Vashakidze has nothing to disclose.
Conflict of interest: S. Gogishvili has nothing to disclose.
Conflict of interest: K. Nikolaishvili has nothing to disclose.
Conflict of interest: A. Despuig reports grants from Spanish Government-FEDER Funds and the CIBER Enfermedades Respiratorias Network (CIBERES), and personal fees from Agència de Gestió d'Ajuts Universitaris i de Recerca AGAUR, during the conduct of the study.
Conflict of interest: N. Tukvadze has nothing to disclose.
Conflict of interest: N. Shubladze has nothing to disclose.
Conflict of interest: Z. Avaliani has nothing to disclose.
Conflict of interest: C. Vilaplana reports personal fees from Spanish Government-FEDER Contratos Miguel Servet, and grants from Spanish Government-FEDER, CIBERES), grants from the Spanish Society of Pneumology and Thoracic Surgery (SEPAR), during the conduct of the study.
Support statement: This study was funded by the Spanish Government-FEDER Funds through CV contracts CP13/00174, CPII14/00021 and PI16/01511 grant; the “CIBER Enfermedades Respiratorias” Network (CIBERES); the “Spanish Society of Pneumology and Thoracic Surgery” (SEPAR) through grant 16/023; and the “Agència de Gestió d'Ajuts Universitaris i de Recerca” (AGAUR) through AD contract (2017 FI_B_00797). Funding information for this article has been deposited with the Crossref Funder Registry.
- Received February 21, 2020.
- Accepted May 29, 2020.
- Copyright ©ERS 2020
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