Abstract
Sarcoidosis and tuberculosis share several similar clinical and pathogenic characteristics that make some researchers consider a common pathogenesis for these diseases. Human leukocyte antigen (HLA) genotypes are studied both in sarcoidosis and tuberculosis patients, but to our knowledge, there are no comparative studies of genetic predisposition for sarcoidosis and tuberculosis development.
The aim of this review was to analyse the relationship between HLA genotypes and the development of sarcoidosis and tuberculosis. Original and review articles published in various online databases from 1960 to 2019 were studied.
The search results showed opposite effects of the HLA genotypes on predisposition to sarcoidosis or tuberculosis. It was revealed that the genotypes predisposing to the development of sarcoidosis (HLA-DRB1*03/07/15) have protective properties against the development of tuberculosis. Moreover, genotypes causing the development of tuberculosis (HLA-DRB1*04) have a protective effect on the development of sarcoidosis.
The results of this narrative review of the literature may allude to the existence of genetic predispositions that lead to the development of an antibacterial or autoimmune response to mycobacteria.
Abstract
The HLA-DRB1*03/07/15 genotypes predispose to the development of sarcoidosis and have protective properties against the development of tuberculosis, while the HLA-DRB1*04 genotype has an opposite effect on the development of these diseases https://bit.ly/2Tl2rj1
Footnotes
Conflict of interest: A. Malkova has nothing to disclose.
Conflict of interest: A. Starshinova has nothing to disclose.
Conflict of interest: Y. Zinchenko has nothing to disclose.
Conflict of interest: N. Basantsova has nothing to disclose.
Conflict of interest: V.A. Mayevskaya has nothing to disclose.
Conflict of interest: P. Yablonskiy has nothing to disclose.
Conflict of interest: Y. Shoenfeld has nothing to disclose.
Support statement: This work was supported by a grant from the Government of the Russian Federation (contract No. 14.W03.31.0009 dated February 13, 2017) on the allocation of grants for the state support of scientific researches conducted under the guidance of leading scientists. Funding information for this article has been deposited with the Crossref Funder Registry.
- Received December 10, 2019.
- Accepted May 13, 2020.
- Copyright ©ERS 2020
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