Figures
- FIGURE 1
The five devices and valved holding chambers used in the study: a) Tips-haler spacer; b) Dolphin chamber; c) homemade spacer from a water bottle; d) Aerochamber plus flow Vu chamber; e) Able spacer.
- FIGURE 2
Schematic diagram illustrating the measurement of total inhalable dose using a)metered-dose inhaler (MDI) alone, b) MDI with mouthpiece spacer and c) MDI with facemask spacer.
Tables
- TABLE 1
Outcome of salbutamol dose delivered via metered-dose inhaler (MDI) and different MDI–spacer combinations in 4 L volume of inhalation (assuming adult inhalation volume)
MDI or MDI/accessory device Nature Emitted dose % Dose deposited in spacer % MDI only 86.8 ± 5.1 NA Aerochamber mouthpiece Antistatic 71.6 ± 4.4 16.8 ± 3.30 Aerochamber mask Antistatic 69.7 ± 5.4 18.9 ± 4.9 Able spacer mouthpiece Antistatic 64.2 ± 6.9 23.2 ± 4.3 Able spacer mask Antistatic 61.2 ± 6.6 24.1 ± 4.9 Tips-haler mouthpiece Antistatic 53.6 ± 7.2 34.4 ± 7.4 Tips-haler mask Antistatic 51.3 ± 4.7 34.6 ± 5.8 Dolphin chamber mouthpiece Non-antistatic 31.9 ± 5.4 56 ± 4.7 Dolphin chamber mask Non-antistatic 30.5 ± 5.6 55.2 ± 9.7 Dolphin chamber wash Non-antistatic 49.7 ± 6.4 NA Drink bottle mouthpiece Non-antistatic 35.3 ± 6.9 50.2 ± 4.3 Drink bottle wash Non-antistatic 51.2 ± 7.1 NA Data are presented as mean±sd. NA: not applicable.
- TABLE 2
Outcome of salbutamol dose delivered via metered-dose inhaler (MDI) and different MDI–spacer combinations in 2 L volume of inhalation (assuming old child inhalation volume)
MDI or MDI/accessory device Nature Emitted dose % Dose deposited in spacer % MDI only 87.2 ± 6.9 NA Aerochamber mask Antistatic 69.8 ± 5.8 18.7 ± 4.1 Able spacer mouthpiece Antistatic 66.2 ± 6 22.3 ± 4.3 Able spacer mask Antistatic 64.3 ± 5.1 24.1 ± 4.9 Tips-haler mouthpiece Antistatic 53.9 ± 6.5 38.2 ± 4.5 Tips-haler mask Antistatic 51.5 ± 6.1 34.5 ± 6 Dolphin chamber mouthpiece Non-antistatic 32.4 ± 6.7 53.7 ± 5.5 Dolphin chamber mask Non-antistatic 32.2 ± 6.4 57.6 ± 3.5 Dolphin chamber wash Non-antistatic 47.6 ± 5.9 NA Drink bottle mouthpiece Non-antistatic 34.3 ± 7.3 54 ± 9.3 Drink bottle wash Non-antistatic 49.9 ± 6.2 NA Data are presented as mean±sd. NA: not applicable.
- TABLE 3
Outcome of salbutamol dose delivered via metered-dose inhaler (MDI) and different MDI–spacer combinations in 1 L volume of inhalation (assuming young child inhalation volume)
MDI or MDI/accessory device Nature Emitted dose % Dose deposited in spacer % MDI only 84.1 ± 6 NA Aerochamber mask Antistatic 58.3 ± 6.5 30.1 ± 6.9 Able spacer mask Antistatic 55.6 ± 6.3 31.6 ± 4.2 Tips-haler mask Antistatic 46.4 ± 5.8 38.3 ± 9.8 Data are presented as mean±sd. NA: not applicable.
