Skip to main content

Main menu

  • Home
  • Current issue
  • Early View
  • Archive
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • COVID-19 submission information
    • Institutional open access agreements
    • Peer reviewer login
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • Early View
  • Archive
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • COVID-19 submission information
    • Institutional open access agreements
    • Peer reviewer login
  • Alerts
  • Subscriptions

Post hoc analysis of a randomised controlled trial: effect of vitamin D supplementation on circulating levels of desmosine in COPD

Rob Janssen, Jef Serré, Ianthe Piscaer, Ruben Zaal, Henny van Daal, Carolien Mathyssen, Pieter Zanen, Jody M.W. van den Ouweland, Wim Janssens
ERJ Open Research 2020 6: 00128-2019; DOI: 10.1183/23120541.00128-2019
Rob Janssen
1Dept of Pulmonary Medicine, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Rob Janssen
  • For correspondence: rob.janssen@cwz.nl
Jef Serré
2Laboratory of Respiratory Diseases, Catholic University Leuven, Leuven, Belgium
7Both authors contributed equally to the study
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jef Serré
Ianthe Piscaer
3Dept of Respiratory Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands
7Both authors contributed equally to the study
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ruben Zaal
4Ziekenhuisgroep Twente, Hengelo, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Henny van Daal
5Clinical Chemistry, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carolien Mathyssen
2Laboratory of Respiratory Diseases, Catholic University Leuven, Leuven, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pieter Zanen
6Dept of Respiratory Medicine, Division of Heart and Lungs, University Medical Centre Utrecht, Utrecht, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jody M.W. van den Ouweland
5Clinical Chemistry, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wim Janssens
2Laboratory of Respiratory Diseases, Catholic University Leuven, Leuven, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Wim Janssens
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Figures

  • Tables
  • FIGURE 1
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 1

    25(OH)D levels in placebo and intervention groups at baseline and 12 months. Boxplots (5th percentile, 1st quartile, median, 3rd quartile and 95th percentile) showing serum 25(OH) levels (ng.mL−1) at baseline (pre; n=71 in both groups) and 12 months (post; n=61 in placebo arm and n=56 in intervention arm). No significant difference in serum 25(OH)D levels was found between the placebo and intervention arm at baseline. 25(OH)D levels were significantly higher in the intervention arm compared to the placebo arm at 12 months (p<0.001).

  • FIGURE 2
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 2

    Association between 25(OH)D levels and desmosine at baseline. Scatter plot showing the relationship between baseline serum 25(OH) levels (ng.mL−1) and plasma desmosine levels (µg.L−1). No significant relationship was found (p=0.842). All 142 patients from both the placebo and intervention group were included at baseline.

  • FIGURE 3
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 3

    Effect of vitamin D and placebo on desmosine levels. Boxplots (5th percentile, 1st quartile, median, 3rd quartile and 95th percentile) showing plasma desmosine levels (µg.L−1) in placebo and intervention arms at four time points: baseline (T=0), 4 months (T=4), 8 months (T=8) and 12 months (T=12). No significant difference in plasma desmosine levels was found between the placebo and intervention arm at any of the four time points.

  • FIGURE 4
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 4

    Effect of baseline 25(OH)D levels on desmosine change after vitamin D supplementation. Boxplots (5th percentile, 1st quartile, median, 3rd quartile and 95th percentile) showing the change in plasma desmosine levels (µg.L−1) over the course of the study and serum 25(OH)D levels (ng.mL−1) at baseline. A significant inverse correlation was found between the groups (p=0.002).

  • FIGURE 5
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 5

    Association between phosphate and desmosine levels at baseline. Scatterplot showing the association between baseline serum phosphate (mg.dL−1) and plasma desmosine levels (µg.L−1). All 142 patients from both the placebo and intervention group were included. A significant positive association was found between both variables (p<0.0001). Plasma desmosine = −0.739 + (age)*0.008 − (baseline serum phosphate)*0.233 (η2=0.157 and adjusted η2=0.145).

Tables

  • Figures
  • TABLE 1

    Baseline characteristics

    CharacteristicVitamin D groupPlacebo groupp-value
    Subjects n
    Men
    71
    59 (83)
    71
    62 (87)
    0.482
    Age years68±968±80.649
    Smoking status
     Current smokers13 (18)16 (23)0.288
    FEV1 L1.25±0.451.22±0.440.635
    FEV1 % pred45±1643±140.508
    FVC L2.82±0.802.95±0.880.377
    FEV1/FVC ratio0.44±0.120.42±0.110.239
    DLCO % pred48±1750±160.538
    GOLD stage
     I1 (1)0 (0)0.319
     II21 (30)19 (27)0.715
     III32 (45)38 (54)0.317
     IV17 (24)14 (20)0.546

    Baseline characteristics of vitamin D and placebo groups at randomisation. Both groups were matched for all given variables. Data are presented as n (%) or mean±sd, unless otherwise stated. FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; DLCO: diffusing capacity of the lung for carbon monoxide; GOLD: Global Initiative for Chronic Obstructive Lung Disease.

    PreviousNext
    Back to top
    Vol 6 Issue 4 Table of Contents
    ERJ Open Research: 6 (4)
    • Table of Contents
    • Index by author
    Email

    Thank you for your interest in spreading the word on European Respiratory Society .

    NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

    Enter multiple addresses on separate lines or separate them with commas.
    Post hoc analysis of a randomised controlled trial: effect of vitamin D supplementation on circulating levels of desmosine in COPD
    (Your Name) has sent you a message from European Respiratory Society
    (Your Name) thought you would like to see the European Respiratory Society web site.
    CAPTCHA
    This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
    Print
    Citation Tools
    Post hoc analysis of a randomised controlled trial: effect of vitamin D supplementation on circulating levels of desmosine in COPD
    Rob Janssen, Jef Serré, Ianthe Piscaer, Ruben Zaal, Henny van Daal, Carolien Mathyssen, Pieter Zanen, Jody M.W. van den Ouweland, Wim Janssens
    ERJ Open Research Oct 2020, 6 (4) 00128-2019; DOI: 10.1183/23120541.00128-2019

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
    Share
    Post hoc analysis of a randomised controlled trial: effect of vitamin D supplementation on circulating levels of desmosine in COPD
    Rob Janssen, Jef Serré, Ianthe Piscaer, Ruben Zaal, Henny van Daal, Carolien Mathyssen, Pieter Zanen, Jody M.W. van den Ouweland, Wim Janssens
    ERJ Open Research Oct 2020, 6 (4) 00128-2019; DOI: 10.1183/23120541.00128-2019
    del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
    Full Text (PDF)

    Jump To

    • Article
      • Abstract
      • Abstract
      • Introduction
      • Methods
      • Results
      • Discussion
      • Acknowledgements
      • Footnotes
      • References
    • Figures & Data
    • Info & Metrics
    • PDF

    Subjects

    • COPD and smoking
    • Tweet Widget
    • Facebook Like
    • Google Plus One

    More in this TOC Section

    Original articles

    • BMI and in-hospital mortality in patients with AE-IPF
    • Characteristics and impact of EILO
    • A common model for the breathlessness experience
    Show more Original articles

    COPD

    • CLE and PSE on CT in smokers with PRISm
    • Physiological changes in symptomatic smokers
    • ELVR and physical activity coaching in severe emphysema
    Show more COPD

    Related Articles

    Navigate

    • Home
    • Current issue
    • Archive

    About ERJ Open Research

    • Editorial board
    • Journal information
    • Press
    • Permissions and reprints
    • Advertising

    The European Respiratory Society

    • Society home
    • myERS
    • Privacy policy
    • Accessibility

    ERS publications

    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS books online
    • ERS Bookshop

    Help

    • Feedback

    For authors

    • Instructions for authors
    • Publication ethics and malpractice
    • Submit a manuscript

    For readers

    • Alerts
    • Subjects
    • RSS

    Subscriptions

    • Accessing the ERS publications

    Contact us

    European Respiratory Society
    442 Glossop Road
    Sheffield S10 2PX
    United Kingdom
    Tel: +44 114 2672860
    Email: journals@ersnet.org

    ISSN

    Online ISSN: 2312-0541

    Copyright © 2022 by the European Respiratory Society