Receptor | CNR1 | Cannabinoid receptor 1 (CB1) | Primary receptor involved in endocannabinoid signalling | [23] |
CNR2 | Cannabinoid receptor 2 (CB2) | Primary receptor involved in endocannabinoid signalling | [24] |
GABRA2 | γ-aminobutyric acid receptor subunit α-2 (GABRA2) | Implicated in cannabis dependency | [38] |
GPR55 | G protein-coupled receptor 55 (GPR55) | Novel cannabinoid receptor | [26] |
OPRM1 | Opioid receptor μ1 (MOR1) | Implicated in cannabis dependency | [38] |
TRPV1 | Transient receptor potential vanilloid 1 (TRPV1) | Novel cannabinoid receptor | [25] |
Enzyme | ABHD12 | 2-AG hydrolase ABHD12 (ABHD12) | Degradation of 2-AG | [39] |
ABHD6 | 2-AG hydrolase ABHD6 (ABHD6) | Degradation of 2-AG | [40] |
ADCY3 | Adenylyl cyclase 3 (AC) | Catalyses formation of cAMP | [41] |
AKT1 | AKT serine/threonine kinase 1 (AKT) | Regulates cell survival | [42] |
COMT | Catechol-O-methyltransferase (COMT) | Degradation of dopamine | [43] |
CYP2C9 | Cytochrome P450 2C9 (CYP2C9) | Metabolism of THC | [44] |
CYP3A4 | Cytochrome P450 3A4 (CYP3A4) | Metabolism of THC | [44] |
DAGLA | Diacylglycerol lipase α (DAGLA) | Biosynthesis of 2-AG | [57] |
DAGLB | Diacylglycerol lipase β (DAGLB) | Biosynthesis of 2-AG | [57] |
DUSP6 | Dual-specificity phosphatase 6 (MKP3) | Regulates MAPK signalling | [45] |
FAAH | Fatty acid amide hydrolase (FAAH) | Degradation of AEA | [46] |
FAAH2 | Fatty acid amide hydrolase 2 (FAAH2) | Degradation of AEA | [58] |
MAPK14 | Mitogen-activated protein kinase 14 (MAPK14) | Regulates cell survival | [47] |
MAP2K2 | Mitogen-activated protein kinase kinase 2 (MAP2K2) | Regulates cell survival | [45] |
MAPK3 | Extracellular signal-regulated kinase (MAKP3) | Regulates cell survival | [48] |
MGLL | Monoglyceride lipase (MAGL) | Degradation of 2-AG | [49] |
NAAA | N-acylethanolamine acid amidase (NAAA) | Degradation of AEA | [59] |
NAPEPLD | N-acylphosphatidylethanolamine phospholipase D (NAPEPLD) | Biosynthesis of AEA | [60] |
NOS2 | Inducible nitric oxide synthase (iNOS) | Inflammatory mediator | [50] |
PIK3CA | Phosphatidylinositol-3-kinase (PI3 K) | Regulates cell survival | [42] |
PRKACA | Protein kinase-A (PKA) | Regulates cell survival | [51] |
PTGS2 | Cyclooxygenase-2 (COX2) | Inflammatory mediator | [52] |
Other proteins | ABCB1 | P-glycoprotein 1 (p-GP) | Cannabinoid transportation | [53] |
GNAI1 | Gi/o α subunit (Gi/o) | Coupled to cannabinoid receptors | [54] |
NRG1 | Neuregulin 1 (NRG1) | Mediates cell–cell signalling | [55] |
TP53 | Tumour protein p53 (p53) | Regulates cell survival | [56] |