Figures
- FIGURE 1
Levels of a) total protein, lactate dehydrogenase (LDH), α1-antitrypsin and neutrophil elastase in bronchoalveolar lavage fluid (BALF) and b) 8-isoprostane, interleukin (IL)-6 and caspase-3 in lungs after 3 and 6 months (M) of exposure to traffic-related ambient air. Rats were exposed to particulate matter with an aerodynamic diameter <1 µm (PM1; PM1 group) or high-efficiency particulate air (HEPA)-filtered air (HEPA group, gaseous pollution). Rats in the control group were housed in the animal centre. n=8 per group. *: p<0.05.
- FIGURE 2
Haematoxylin and eosin staining of lungs after 6 months (M), from a) control rats, and from rats exposed to b) high-efficiency particulate air (HEPA)-filtered air or c) particulate matter with an aerodynamic diameter <1 μm (PM1). d) Emphysema mean linear intercept (MLI) score after air pollution exposure. Significant emphysema occurred after 6 months of PM1 exposure in rats. n=8 per group. *: p<0.05.
- FIGURE 3
Levels of a) angiotensin-converting enzyme 2 (ACE2), b) angiotensin II receptor type 1 (AT1) and c) angiotensin II receptor type 2 (AT2) in rat lungs after 3 and 6 months (M) of exposure to traffic-related ambient air. Rats were exposed to high-efficiency particulate air (HEPA)-filtered air or particulate matter with an aerodynamic diameter <1 μm (PM1). Rats in the control group were housed in the animal centre. n=8 per group. *: p<0.05.
- FIGURE 4
Haematoxylin and eosin staining of blood vessels after 6 months of air pollution exposure. Rats were exposed to high-efficiency particulate air (HEPA)-filtered air or particulate matter with an aerodynamic diameter <1 μm (PM1). Rats in the control group were housed in the animal centre. Two different sections of blood vessels are shown for each group. A significant increase in smooth muscle hypertrophy occurred after 6 months of PM1 exposure in rats.
Supplementary Materials
Supplementary Material
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FIGURE S1 Correlation between PM1 exposure to rats and ambient PM2.5. 00174-2020.figureS1
