The association of pulmonary fibrosis with diabetes mellitus

Niranjan Jeganathan; Christelle Miot; Airani Sathananthan; Matheni Sathananthan

doi:10.1183/23120541.00237-2020

Tables

TABLE 1

Prevalence of pulmonary fibrosis (PF) in decedents with and without diabetes mellitus (DM)

Variable	Decedents without DM^#					Decedents with DM^¶					OR⁺ (95% CI)
Variable	Total deaths	PF present	Total deaths with PF %	PF mortality rate % change 2007–2017	p-value for trend	Total deaths	PF present	Total deaths with PF %	PF mortality rate % change 2007–2017	p-value for trend	OR⁺ (95% CI)
Sex
Female	12 136 433	86 119	0.71	−4.5	0.07	1 243 509	7022	0.56	−14.0	−0.01	0.79 (0.78–0.81)
Male	11 551 233	104 316	0.90	+6.0	0.03	1 374 393	9964	0.72			0.80 (0.78–0.82)
Age years
45–54	1 803 885	4879	0.27	−17.3	0.001	172 621	374	0.22			0.80 (0.72–0.89)
55–64	3 221 877	16 158	0.50	−16.7	<0.001	411 616	1645	0.40	−17.8	0.03	0.80 (0.76–0.84)
65–74	4 296 696	40 423	0.95	−13.7	<0.001	614 378	4352	0.71	−24.6	<0.001	0.75 (0.73–0.78)
75–84	6 221 180	69 375	1.12	−2.17	0.002	766 851	6443	0.84	−6.3	0.001	0.75 (0.73–0.77)
≥85	8 144 028	59 600	0.73	+3.4	0.03	652 436	4172	0.64			0.87 (0.85–0.90)
Race
Native-American	118 036	1433	1.21	+24.1	<0.001	24 513	207	0.84			0.69 (0.60–0.80)
Asian	490 443	4407	0.90			75 862	518	0.68			0.76 (0.69–0.83)
Black	2 466 550	8795	0.36	−8.0	0.01	382 789	1213	0.32	−17.8	0.003	0.89 (0.84–0.94)
White	19 327 231	161 217	0.83	+5.1	0.06	1 895 444	13 132	0.69			0.83 (0.81–0.84)
Hispanic	1 223 991	14 279	1.17			231 954	1883	0.81			0.69 (0.66–0.73)
UCD
PF		132 322					9807				0.60 (0.58–0.62)
Ischaemic heart disease		9153		−27.7	0.002		1486				1.90 (1.79–2.01)
Lung cancer		4930					391				0.89 (0.80–0.98)
Pneumonia		1737					97				0.62 (0.51–0.77)
Heart failure		1380					118				0.96 (0.79–1.16)
Cerebrovascular disease		1241					152				1.38 (1.16–1.63)
Pulmonary heart		875					77				0.99 (0.78–1.25)
disease
Other		38 797					4858				1.57 (1.51–1.62)

International Classification of Diseases, 10th revision, codes used for underlying cause of death (UCD) are as follows. Pulmonary fibrosis: J84.1; ischaemic heart disease: I20–I25; lung cancer: C34–C34.9; pneumonia: J09–J18.9; heart failure: I50–I50.9; cerebrovascular disease: I60–I69.8; pulmonary heart disease: I26–I27.9. If no data are shown for % change in rate, the regression analysis of the data did not indicate a significant change in trend during the time period. ^#: n=23 687 666; ^¶: n=2 617 902; ⁺: the overall risk of PF in diabetics compared to nondiabetics.