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The risks of applying normative values in paediatric cardiopulmonary exercise testing: a case report

Jessica L. Waterfall, Paul Burns, Dawn Shackell, Joanna Pepke-Zaba, Katrina E. Oates, Karl P. Sylvester
ERJ Open Research 2020 6: 00333-2020; DOI: 10.1183/23120541.00333-2020
Jessica L. Waterfall
1Respiratory Physiology, Royal Papworth Hospital NHSFT, Cambridge, UK
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  • ORCID record for Jessica L. Waterfall
Paul Burns
2Respiratory and Sleep Physiology Dept, Queen Elizabeth University Hospitals, Glasgow, UK
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Dawn Shackell
3Respiratory Physiology, Norfolk and Norwich University Hospital NHSFT, Norwich, UK
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Joanna Pepke-Zaba
4Pulmonary Vascular Disease Unit, Royal Papworth Hospital NHSFT, Cambridge, UK
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Katrina E. Oates
1Respiratory Physiology, Royal Papworth Hospital NHSFT, Cambridge, UK
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Karl P. Sylvester
1Respiratory Physiology, Royal Papworth Hospital NHSFT, Cambridge, UK
5Lung Function Unit, Cambridge University Hospitals NHSFT, Cambridge, UK
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  • For correspondence: karl.sylvester@nhs.net
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Tables

  • TABLE 1

    Results for cardiopulmonary exercise testing (CPET) parameters with two different normative reference values (NRV) applied

    CPET variablesNorfolk and Norwich Hospital (Dec 2018)Royal Papworth Hospital (Dec 2019)
    Results (absolute)Bongers 8–18 years (2014) % predCooper 6–17 years (1984) % predResults (absolute)Bongers 8–18 years (2014) % predCooper 6–17 years (1984) % pred
    Load W8942%62%9846%71%
    V′O2peak mL·min139155%70%139355%73%
    V′O2peak mL·min ·kg23.556%70%24.559%73%
    V′O2@ AT mL·min879788
    O2pulse mL8.968%96%8.162%90%
    V′E/V′CO2slope4552
    V′EEqCO2 AT4442
    Lowest oxygen saturation %8588
    Cardiovascular slopeNormalNormal
    Ratio (%)Ratio (%)
    AT % pred V′O2max35%44%31%41%

    V′O2peak: peak oxygen consumption; V′O2 @ AT: oxygen consumption at anaerobic capacity; V′EEqCO2 at AT: ventilatory equivalents for carbon dioxide at anaerobic threshold; AT % pred V′O2max: anaerobic capacity as a per cent of maximal predicted oxygen consumption. V′E/V′CO2 slope: The slope of the relationship between ventilation and carbon dioxide production.

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    The risks of applying normative values in paediatric cardiopulmonary exercise testing: a case report
    Jessica L. Waterfall, Paul Burns, Dawn Shackell, Joanna Pepke-Zaba, Katrina E. Oates, Karl P. Sylvester
    ERJ Open Research Oct 2020, 6 (4) 00333-2020; DOI: 10.1183/23120541.00333-2020

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    The risks of applying normative values in paediatric cardiopulmonary exercise testing: a case report
    Jessica L. Waterfall, Paul Burns, Dawn Shackell, Joanna Pepke-Zaba, Katrina E. Oates, Karl P. Sylvester
    ERJ Open Research Oct 2020, 6 (4) 00333-2020; DOI: 10.1183/23120541.00333-2020
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