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Multiple breath washout in bronchiectasis clinical trials: is it feasible?

Katherine O'Neill, Kathryn Ferguson, Denis Cosgrove, Michael M. Tunney, Anthony De Soyza, Mary Carroll, James D. Chalmers, Timothy Gatheral, Adam T. Hill, John R. Hurst, Christopher Johnson, Michael R. Loebinger, Gerhild Angyalosi, Charles S. Haworth, Renee Jensen, Felix Ratjen, Clare Saunders, Christopher Short, Jane C. Davies, J. Stuart Elborn, Judy M. Bradley
ERJ Open Research 2020 6: 00363-2019; DOI: 10.1183/23120541.00363-2019
Katherine O'Neill
1Wellcome–Wolfson Institute for Experimental Medicine, Queen's University – Belfast, Belfast, UK
15On behalf of the BRONCH-UK consortium
16On behalf of the i-BEST-1 Trial Team
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  • For correspondence: k.oneill@qub.ac.uk
Kathryn Ferguson
2Belfast Health and Social Care Trust, Belfast, UK
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Denis Cosgrove
2Belfast Health and Social Care Trust, Belfast, UK
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Michael M. Tunney
3School of Pharmacy, Queen's University – Belfast, Belfast, UK
16On behalf of the i-BEST-1 Trial Team
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Anthony De Soyza
4Newcastle University, Newcastle upon Tyne, UK
15On behalf of the BRONCH-UK consortium
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  • ORCID record for Anthony De Soyza
Mary Carroll
5University Hospital Southampton NHS Foundation Trust, Southampton, UK
15On behalf of the BRONCH-UK consortium
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James D. Chalmers
6University of Dundee, College of Medicine, Dundee, UK
15On behalf of the BRONCH-UK consortium
16On behalf of the i-BEST-1 Trial Team
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Timothy Gatheral
7Department of Respiratory Medicine, University Hospitals of Morecambe Bay NHS Foundation Trust, Morecambe Bay, UK
15On behalf of the BRONCH-UK consortium
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Adam T. Hill
8Royal Infirmary and University of Edinburgh, Edinburgh, Scotland, UK
15On behalf of the BRONCH-UK consortium
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John R. Hurst
9UCL Respiratory, University College London, London, UK
15On behalf of the BRONCH-UK consortium
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Christopher Johnson
10Cambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge, UK
15On behalf of the BRONCH-UK consortium
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Michael R. Loebinger
11National Heart and Lung Institute, Imperial College London, London, UK
12Royal Brompton and Harefield NHS Foundation Trust, London, UK
15On behalf of the BRONCH-UK consortium
16On behalf of the i-BEST-1 Trial Team
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Gerhild Angyalosi
13Novartis Pharma AG, Basel, Switzerland
16On behalf of the i-BEST-1 Trial Team
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Charles S. Haworth
10Cambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge, UK
16On behalf of the i-BEST-1 Trial Team
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Renee Jensen
14University of Toronto, Toronto, Canada
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Felix Ratjen
14University of Toronto, Toronto, Canada
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Clare Saunders
11National Heart and Lung Institute, Imperial College London, London, UK
12Royal Brompton and Harefield NHS Foundation Trust, London, UK
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Christopher Short
11National Heart and Lung Institute, Imperial College London, London, UK
12Royal Brompton and Harefield NHS Foundation Trust, London, UK
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Jane C. Davies
11National Heart and Lung Institute, Imperial College London, London, UK
12Royal Brompton and Harefield NHS Foundation Trust, London, UK
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J. Stuart Elborn
1Wellcome–Wolfson Institute for Experimental Medicine, Queen's University – Belfast, Belfast, UK
15On behalf of the BRONCH-UK consortium
16On behalf of the i-BEST-1 Trial Team
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Judy M. Bradley
1Wellcome–Wolfson Institute for Experimental Medicine, Queen's University – Belfast, Belfast, UK
15On behalf of the BRONCH-UK consortium
16On behalf of the i-BEST-1 Trial Team
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Article Information

vol. 6 no. 4
DOI 
https://doi.org/10.1183/23120541.00363-2019
PubMed 
33083441

Published By 
European Respiratory Society
Online ISSN 
2312-0541
History 
  • Received December 20, 2019
  • Accepted July 19, 2020
  • Published online October 13, 2020.

Copyright & Usage 
Copyright ©ERS 2020 This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

Author Information

  1. Katherine O'Neill1,15,16⇑,
  2. Kathryn Ferguson2,
  3. Denis Cosgrove2,
  4. Michael M. Tunney3,16,
  5. Anthony De Soyza4,15,
  6. Mary Carroll5,15,
  7. James D. Chalmers6,15,16,
  8. Timothy Gatheral7,15,
  9. Adam T. Hill8,15,
  10. John R. Hurst9,15,
  11. Christopher Johnson10,15,
  12. Michael R. Loebinger11,12,15,16,
  13. Gerhild Angyalosi13,16,
  14. Charles S. Haworth10,16,
  15. Renee Jensen14,
  16. Felix Ratjen14,
  17. Clare Saunders11,12,
  18. Christopher Short11,12,
  19. Jane C. Davies11,12,
  20. J. Stuart Elborn1,15,16 and
  21. Judy M. Bradley1,15,16
  1. 1Wellcome–Wolfson Institute for Experimental Medicine, Queen's University – Belfast, Belfast, UK
  2. 2Belfast Health and Social Care Trust, Belfast, UK
  3. 3School of Pharmacy, Queen's University – Belfast, Belfast, UK
  4. 4Newcastle University, Newcastle upon Tyne, UK
  5. 5University Hospital Southampton NHS Foundation Trust, Southampton, UK
  6. 6University of Dundee, College of Medicine, Dundee, UK
  7. 7Department of Respiratory Medicine, University Hospitals of Morecambe Bay NHS Foundation Trust, Morecambe Bay, UK
  8. 8Royal Infirmary and University of Edinburgh, Edinburgh, Scotland, UK
  9. 9UCL Respiratory, University College London, London, UK
  10. 10Cambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge, UK
  11. 11National Heart and Lung Institute, Imperial College London, London, UK
  12. 12Royal Brompton and Harefield NHS Foundation Trust, London, UK
  13. 13Novartis Pharma AG, Basel, Switzerland
  14. 14University of Toronto, Toronto, Canada
  15. 15On behalf of the BRONCH-UK consortium
  16. 16On behalf of the i-BEST-1 Trial Team
  1. Katherine O'Neill, Wellcome–Wolfson Institute for Experimental Medicine, Queen's University – Belfast, Medical Biology Centre, Lisburn Road, Belfast, BT9 7AB, UK. E-mail: k.oneill{at}qub.ac.uk
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Funding

  • EU/EFPIA IMI-JU iABC

    115721
  • Medical Research Council

    MR/L011263/1

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Multiple breath washout in bronchiectasis clinical trials: is it feasible?
Katherine O'Neill, Kathryn Ferguson, Denis Cosgrove, Michael M. Tunney, Anthony De Soyza, Mary Carroll, James D. Chalmers, Timothy Gatheral, Adam T. Hill, John R. Hurst, Christopher Johnson, Michael R. Loebinger, Gerhild Angyalosi, Charles S. Haworth, Renee Jensen, Felix Ratjen, Clare Saunders, Christopher Short, Jane C. Davies, J. Stuart Elborn, Judy M. Bradley
ERJ Open Research Oct 2020, 6 (4) 00363-2019; DOI: 10.1183/23120541.00363-2019

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Multiple breath washout in bronchiectasis clinical trials: is it feasible?
Katherine O'Neill, Kathryn Ferguson, Denis Cosgrove, Michael M. Tunney, Anthony De Soyza, Mary Carroll, James D. Chalmers, Timothy Gatheral, Adam T. Hill, John R. Hurst, Christopher Johnson, Michael R. Loebinger, Gerhild Angyalosi, Charles S. Haworth, Renee Jensen, Felix Ratjen, Clare Saunders, Christopher Short, Jane C. Davies, J. Stuart Elborn, Judy M. Bradley
ERJ Open Research Oct 2020, 6 (4) 00363-2019; DOI: 10.1183/23120541.00363-2019
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