Figures
- FIGURE 1
Central over-reading outcome from BronchUK Clinimetrics study (testing sessions from 142 subjects over 8 visits). MBW: multiple breath washout. #: re-run of tests completed but did not resolve the misalignment or re-run not possible due to A-files not being saved.
- FIGURE 2
Central over-reading outcome from i-BEST-1 trial (testing sessions from 40 subjects over 8 visits). MBW: multiple breath washout. #: re-run of tests completed but did not resolve the misalignment or re-run not possible due to A-files not being saved.
- FIGURE 3
Combined success rate. Clin: Clinimetrics.
Tables
- TABLE 1
Clinimetrics (Clin) multiple breath washout data quality control according to site
Naïve sites Non-naïve sites Overall Site Clin site 1 Clin site 2 Clin site 3 Clin site 4 Clin site 5 Clin site 6 Clin site 7 Total number of testing sessions attempted 116 59 58 88 91 158 19 Site success rate 81/116 (70%) 36/59 (61%) 50/58 (86%) 65/88 (72%) 84/91 (92%) 140/158 (89%) 12/19 (63%) 468/589 Combined success rate naïve versus non-naïve 167/233 (72%) 301/356 (85%) 79% Site success rate first 6 months versus remainder 81%:65% 81%:53% 94%: 83% 74%:74% 72%:100% 94%:88% 64%:60% - TABLE 2
i-BEST-1 multiple breath washout (MBW) data quality control according to site
Naïve sites Non-naïve sites Overall Site i-BEST site 1 i-BEST site 2 i-BEST site 3 i-BEST site 4 i-BEST site 5 i-BEST site 6 i-BEST site 7 i-BEST site 8 i-BEST site 9 i-BEST site 10 i-BEST site 11 Number of testing sessions attempted 20 48 4 65 12 20 10 4 32 8 13 Overall success rate 6/20 (30%) 35/48 (73%) 0/4 (0%) 34/65 (52%) 9/12 (75%) 15/20 (75%) 6/10 (60%) 0/4 (0%) 26/32 (81%) 6/8 (75%) 0/13 (0%) 137/236 Combined success rate naïve versus non-naïve 105/179 (59%) 32/57 (56%) 58% Success rate first 6 months versus remainder 46%:0% 68%:91% 0%:0% 48%:55% 75%:n/a 93%:100% 60%:n/a 0%:0% 84%:72% 86%:0% 0%:0% n/a: No MBW data submitted during this timeframe.
- TABLE 3
Key results from multiple breath washout (MBW) training, certification and data quality control in bronchiectasis research settings
Knowledge and confidence with MBW testing was increased with the training programme 68% of sites completed certification within 6 months Most common barriers to completing MBW certification in bronchiectasis sites were the lack of time and available volunteers to practice testing Success rates were 79% (Clinimetrics study) and 58% (i-BEST-1 study) In the Clinimetrics study, there was no difference in age (p=0.10) or disease severity (p=0.90) as measured by forced expiratory volume in 1 s (at baseline) in those subjects with successful versus those with failed test sessions In the i-BEST-1 study, longer times to certification, a higher percentage of naïve sites and patients with worse lung function may have contributed to the lower success rate Combination of success rate data from both studies showed that success rates were higher in non-naïve sites (81%) compared to naïve sites (66%)
Supplementary Material
Please note: supplementary material is not edited by the Editorial Office, and is uploaded as it has been supplied by the author.
Appendix 1 00363-2019.supplement1
Appendix 2 00363-2019.supplement2
Appendix 3 00363-2019.supplement3
Appendix 4 00363-2019.supplement4
Appendix 5 00363-2019.supplement5
Appendix 6 00363-2019.supplement6
Appendix 7 00363-2019.supplement7
Appendix 8 00363-2019.supplement8
