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Pathophysiology and potential future therapeutic targets using preclinical models of COVID-19

Rahul Kumar, Michael H. Lee, Claudia Mickael, Biruk Kassa, Qadar Pasha, Rubin Tuder, Brian Graham
ERJ Open Research 2020 6: 00405-2020; DOI: 10.1183/23120541.00405-2020
Rahul Kumar
1Dept of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA, USA
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  • For correspondence: rahul.kumar2@ucsf.edu
Michael H. Lee
1Dept of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA, USA
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Claudia Mickael
2Dept of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
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Biruk Kassa
1Dept of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA, USA
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Qadar Pasha
3Functional Genomics Unit, CSIR-Institute of Genomics and Integrative Biology, Delhi, India
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Rubin Tuder
2Dept of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
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Brian Graham
1Dept of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA, USA
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Article Information

vol. 6 no. 4
DOI 
https://doi.org/10.1183/23120541.00405-2020

Published By 
European Respiratory Society
Online ISSN 
2312-0541
History 
  • Received June 20, 2020
  • Accepted October 27, 2020
  • Published online December 7, 2020.

Article Versions

  • previous version (November 6, 2020 - 08:46).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright ©ERS 2020 This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

Author Information

  1. Rahul Kumar1⇑,
  2. Michael H. Lee1,
  3. Claudia Mickael2,
  4. Biruk Kassa1,
  5. Qadar Pasha3,
  6. Rubin Tuder2 and
  7. Brian Graham1
  1. 1Dept of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA, USA
  2. 2Dept of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
  3. 3Functional Genomics Unit, CSIR-Institute of Genomics and Integrative Biology, Delhi, India
  1. Rahul Kumar, Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA 94110, USA. E-mail: rahul.kumar2{at}ucsf.edu
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Funding

  • Pulmonary Hypertension Association

  • National Heart, Lung, and Blood Institute

    P01HL014985; P01HL152961; R01HL135872
  • American Heart Association

    19CDA34730030

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Vol 6 Issue 4 Table of Contents
ERJ Open Research: 6 (4)
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Pathophysiology and potential future therapeutic targets using preclinical models of COVID-19
Rahul Kumar, Michael H. Lee, Claudia Mickael, Biruk Kassa, Qadar Pasha, Rubin Tuder, Brian Graham
ERJ Open Research Oct 2020, 6 (4) 00405-2020; DOI: 10.1183/23120541.00405-2020

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Pathophysiology and potential future therapeutic targets using preclinical models of COVID-19
Rahul Kumar, Michael H. Lee, Claudia Mickael, Biruk Kassa, Qadar Pasha, Rubin Tuder, Brian Graham
ERJ Open Research Oct 2020, 6 (4) 00405-2020; DOI: 10.1183/23120541.00405-2020
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  • Article
    • Abstract
    • Abstract
    • Introduction
    • Origin of SARS-COV-2 and mode of transmission to humans
    • ACE2: a portal of entry for SARS-CoV-2
    • Role of animal models in elucidating the pathogenesis of COVID-19
    • The pulmonary pathophysiology of COVID-19
    • Potential molecular and biochemical therapeutic targets in the host
    • Footnotes
    • References
  • Figures & Data
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  • PDF

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  • Respiratory infections and tuberculosis
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