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Steroid-sparing effects of benralizumab in patients with eosinophilic granulomatosis with polyangiitis

Alexandra M. Nanzer, Jaideep Dhariwal, Joanne Kavanagh, Andrew Hearn, Mariana Fernandes, Louise Thomson, Cris Roxas, Linda Green, Grainne D'Ancona, Sangita Agarwal, Brian D. Kent, David J. Jackson
ERJ Open Research 2020 6: 00451-2020; DOI: 10.1183/23120541.00451-2020
Alexandra M. Nanzer
1Guy's and St Thomas’ NHS Foundation Trust, Thoracic Medicine, Guy's Severe Asthma Service, London, UK
2School of Immunology & Microbial Sciences, King's College London, London, UK
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  • For correspondence: alexandra.nanzerkelly@gstt.nhs.uk
Jaideep Dhariwal
1Guy's and St Thomas’ NHS Foundation Trust, Thoracic Medicine, Guy's Severe Asthma Service, London, UK
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Joanne Kavanagh
1Guy's and St Thomas’ NHS Foundation Trust, Thoracic Medicine, Guy's Severe Asthma Service, London, UK
2School of Immunology & Microbial Sciences, King's College London, London, UK
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Andrew Hearn
1Guy's and St Thomas’ NHS Foundation Trust, Thoracic Medicine, Guy's Severe Asthma Service, London, UK
2School of Immunology & Microbial Sciences, King's College London, London, UK
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Mariana Fernandes
1Guy's and St Thomas’ NHS Foundation Trust, Thoracic Medicine, Guy's Severe Asthma Service, London, UK
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Louise Thomson
1Guy's and St Thomas’ NHS Foundation Trust, Thoracic Medicine, Guy's Severe Asthma Service, London, UK
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Cris Roxas
1Guy's and St Thomas’ NHS Foundation Trust, Thoracic Medicine, Guy's Severe Asthma Service, London, UK
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Linda Green
1Guy's and St Thomas’ NHS Foundation Trust, Thoracic Medicine, Guy's Severe Asthma Service, London, UK
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Grainne D'Ancona
1Guy's and St Thomas’ NHS Foundation Trust, Thoracic Medicine, Guy's Severe Asthma Service, London, UK
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Sangita Agarwal
3Dept of Rheumatology, Guy's and St Thomas’ NHS Foundation Trust, London, UK
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Brian D. Kent
1Guy's and St Thomas’ NHS Foundation Trust, Thoracic Medicine, Guy's Severe Asthma Service, London, UK
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David J. Jackson
1Guy's and St Thomas’ NHS Foundation Trust, Thoracic Medicine, Guy's Severe Asthma Service, London, UK
2School of Immunology & Microbial Sciences, King's College London, London, UK
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    FIGURE 1

    Reduction from baseline to 48 weeks in a) maintenance oral corticosteroid (mOCS) dose (p=0.0018), b) Birmingham Vasculitis Activity Score (BVAS) (p=0.0007) and c) Asthma Control Questionnaire score (ACQ) (p=0.012). Data are presented as a) median (interquartile range) and b and c) mean±sd.

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ERJ Open Research: 6 (4)
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Steroid-sparing effects of benralizumab in patients with eosinophilic granulomatosis with polyangiitis
Alexandra M. Nanzer, Jaideep Dhariwal, Joanne Kavanagh, Andrew Hearn, Mariana Fernandes, Louise Thomson, Cris Roxas, Linda Green, Grainne D'Ancona, Sangita Agarwal, Brian D. Kent, David J. Jackson
ERJ Open Research Oct 2020, 6 (4) 00451-2020; DOI: 10.1183/23120541.00451-2020

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Steroid-sparing effects of benralizumab in patients with eosinophilic granulomatosis with polyangiitis
Alexandra M. Nanzer, Jaideep Dhariwal, Joanne Kavanagh, Andrew Hearn, Mariana Fernandes, Louise Thomson, Cris Roxas, Linda Green, Grainne D'Ancona, Sangita Agarwal, Brian D. Kent, David J. Jackson
ERJ Open Research Oct 2020, 6 (4) 00451-2020; DOI: 10.1183/23120541.00451-2020
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