ERJ Open Research: 7 (1)

01 January 2021; volume 7, issue 1

Reviews

Open Access
Systematic review of diagnostic methods for acute respiratory distress syndrome
Laura A. Hagens, Nanon F.L. Heijnen, Marry R. Smit, Marcus J. Schultz, Dennis C.J.J. Bergmans, Ronny M. Schnabel, Lieuwe D.J. Bos

ERJ Open Res 7: 00504-2020; DOI: 10.1183/23120541.00504-2020 Published 18 January 2021
Open Access
Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes
Grace Y. Lam, Jodi Goodwin, Pearce G. Wilcox, Bradley S. Quon

ERJ Open Res 7: 00475-2020; DOI: 10.1183/23120541.00475-2020 Published 18 January 2021
Open Access
Severe asthma: adding new evidence – Latin American Thoracic Society
Gabriel García, Miguel Bergna, Juan C. Vásquez, Maria C. Cano Salas, José L. Miguel, Carlos Celis Preciado, Agustin Acuña Izcaray, Manuel Barros Monge, Natalia García Batista, Ignacio Zabert, José L. Mayorga, Renato Casanova Mendoza, Martha Gutierrez, Maria F. Montero Arias, Luzcenelia Urtecho Perez, Miguel Antúnez, Victoria Williams Derby, Alejandra Villatoro Azméquita, Luis Motiño, M. Alenita De Oliveira, Diana Rey Sanchez, Marisol Arroyo, Mario Rodriguez

ERJ Open Res 7: 00318-2020; DOI: 10.1183/23120541.00318-2020 Published 18 January 2021
Open Access
Do probiotics help prevent ventilator-associated pneumonia in critically ill patients? A systematic review with meta-analysis
Jie Zhao, Lei-qing Li, Cheng-yang Chen, Gen-sheng Zhang, Wei Cui, Bao-ping Tian

ERJ Open Res 7: 00302-2020; DOI: 10.1183/23120541.00302-2020 Published 25 January 2021
Open Access
Highlights from the Respiratory Failure and Mechanical Ventilation 2020 Conference
Adelaide Withers, Tiffany Choi Ching Man, Rebecca D'Cruz, Heder de Vries, Christoph Fisser, Carla Ribeiro, Neeraj Shah, Marine Van Hollebecke, Bettine A.H. Vosse, Leo Heunks, Maxime Patout

ERJ Open Res 7: 00752-2020; DOI: 10.1183/23120541.00752-2020 Published 8 February 2021
You have accessRestricted access
Assessment of recent evidence for the management of patients with systemic sclerosis-associated interstitial lung disease: a systematic review
Anna-Maria Hoffmann-Vold, Toby M. Maher, Edward E. Philpot, Ali Ashrafzadeh, Oliver Distler

ERJ Open Res 7: 00235-2020; DOI: 10.1183/23120541.00235-2020 Published 22 February 2021
Open Access
The safety of cardioselective β₁-blockers in asthma: literature review and search of global pharmacovigilance safety reports
Miriam Bennett, Catherina L. Chang, Michael Tatley, Ruth Savage, Robert J. Hancox

ERJ Open Res 7: 00801-2020; DOI: 10.1183/23120541.00801-2020 Published 1 March 2021
Open Access
Respiratory care in myotubular myopathy
Hui-leng Tan, Elaine Chan

ERJ Open Res 7: 00641-2020; DOI: 10.1183/23120541.00641-2020 Published 22 March 2021
Open Access
Inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis
Aparna Iyer, Teodora Radonic, Lukas C. Heukamp, Erik Thunnissen, Johannes M.A. Daniels

ERJ Open Res 7: 00151-2020; DOI: 10.1183/23120541.00151-2020 Published 22 March 2021

Congress highlights

Open Access
ERS International Congress 2020: highlights from the General Pneumology Assembly
Luke Daines, Joren Buekers, Beatriz Abascal Bolado, Janwillem W.H. Kocks, Guido Vagheggini, Vitalii Poberezhets, Ioannis Vogiatzis, Hilary Pinnock, Lowie E.G.W. Vanfleteren

ERJ Open Res 7: 00841-2020; DOI: 10.1183/23120541.00841-2020 Published 8 February 2021
Open Access
ERS International Congress 2020: highlights from the Epidemiology and Environment Assembly
Diana A. van der Plaat, Aino K. Rantala, Sheikh M. Alif, Dilek Karadoğan, Yutong Cai, Orianne Dumas

ERJ Open Res 7: 00849-2020; DOI: 10.1183/23120541.00849-2020 Published 15 March 2021
Open Access
ERS International Congress 2020: highlights from the Paediatric Assembly
Cristina Ardura-Garcia, Sara Cuevas-Ocaña, Nadine Freitag, Asterios Kampouras, John A. King, Panayiotis Kouis, Sara M. Mensink-Bout, Abigail L. Whitehouse, Emma Williams, Theodore Dassios, Liesbeth Duijts, Refika H Ersu, Erol A. Gaillard, Alex R. Horsley, Marijke Proesmans, Robbert Rottier, Dirk Schramm, Alexander Moeller, Marielle W. Pijnenburg

ERJ Open Res 7: 00893-2020; DOI: 10.1183/23120541.00893-2020 Published 22 March 2021
Open Access
ERS International Congress 2020: highlights from the Thoracic Surgery and Transplantation Assembly
Dorina Esendagli, Unmil Shah, Guntug Batihan, Dimitrios Magouliotis, Federica Meloni, Robin Vos, Stefano Elia, Merel Hellemons

ERJ Open Res 7: 00743-2020; DOI: 10.1183/23120541.00743-2020 Published 15 March 2021
Open Access
ERS International Congress 2020 Virtual: highlights from the Allied Respiratory Professionals Assembly
Elizabeth Smith, Max Thomas, Ebru Calik-Kutukcu, Irene Torres-Sánchez, Maria Granados-Santiago, Juan Carlos Quijano-Campos, Karl Sylvester, Chris Burtin, Andreja Sajnic, Jana De Brandt, Joana Cruz

ERJ Open Res 7: 00808-2020; DOI: 10.1183/23120541.00808-2020 Published 8 February 2021

Study protocol

Open Access
COVID-PCD: a participatory research study on the impact of COVID-19 in people with primary ciliary dyskinesia
Eva S.L. Pedersen, Eugénie N.R. Collaud, Rebeca Mozun, Cristina Ardura-Garcia, Yin Ting Lam, Amanda Harris, Jane S. Lucas, Fiona Copeland, Michele Manion, Bernhard Rindlisbacher, Hansruedi Silberschmidt, Myrofora Goutaki, Claudia E. Kuehni

ERJ Open Res 7: 00843-2020; DOI: 10.1183/23120541.00843-2020 Published 22 March 2021
Open Access
Integrating Comprehensive Geriatric Assessment for people with COPD and frailty starting pulmonary rehabilitation: the Breathe Plus feasibility trial protocol
Lisa Jane Brighton, Catherine J. Evans, Morag Farquhar, Katherine Bristowe, Aleksandra Kata, Jade Higman, Margaret Ogden, Claire Nolan, Deokhee Yi, Wei Gao, Maria Koulopoulou, Sharmeen Hasan, Claire J. Steves, William D-C. Man, Matthew Maddocks

ERJ Open Res 7: 00717-2020; DOI: 10.1183/23120541.00717-2020 Published 29 March 2021
Open Access
A feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE)
Matthew Northgraves, Judith Cohen, Victoria Allgar, David Currow, Simon Hart, Kelly Hird, Andrew Hodge, Miriam Johnson, Suzanne Mason, Flavia Swan, Ann Hutchinson

ERJ Open Res 7: 00955-2020; DOI: 10.1183/23120541.00955-2020 Published 29 March 2021

Original articles

COVID-19
- Open Access
  COPD in the time of COVID-19: an analysis of acute exacerbations and reported behavioural changes in patients with COPD
  Hamish McAuley, Kate Hadley, Omer Elneima, Christopher E. Brightling, Rachael A. Evans, Michael C. Steiner, Neil J. Greening
  
  ERJ Open Res 7: 00718-2020; DOI: 10.1183/23120541.00718-2020 Published 18 January 2021
- Open Access
  Outcomes of COVID-19 patients treated with continuous positive airway pressure outside the intensive care unit
  Rosanna Vaschetto, Francesco Barone-Adesi, Fabrizio Racca, Claudio Pissaia, Carlo Maestrone, Davide Colombo, Carlo Olivieri, Nello De Vita, Erminio Santangelo, Lorenza Scotti, Luigi Castello, Tiziana Cena, Martina Taverna, Luca Grillenzoni, Maria Adele Moschella, Gianluca Airoldi, Silvio Borrè, Francesco Mojoli, Francesco Della Corte, Marta Baggiani, Sara Baino, Piero Balbo, Simona Bazzano, Valeria Bonato, Sara Carbonati, Federico Crimaldi, Veronica Daffara, Luca De Col, Matteo Maestrone, Mario Malerba, Federica Moroni, Raffaella Perucca, Mario Pirisi, Valentina Rondi, Daniela Rosalba, Letizia Vanni, Francesca Vigone, Paolo Navalesi, Gianmaria Cammarota
  
  ERJ Open Res 7: 00541-2020; DOI: 10.1183/23120541.00541-2020 Published 25 January 2021
- Open Access
  Severe outcomes of COVID-19 among patients with COPD and asthma
  Erik Soeren Halvard Hansen, Amalie Lykkemark Moeller, Vibeke Backer, Mikkel Porsborg Andersen, Lars Kober, Kristian Kragholm, Christian Torp-Pedersen
  
  ERJ Open Res 7: 00594-2020; DOI: 10.1183/23120541.00594-2020 Published 25 January 2021
- Open Access
  Heparin-binding protein levels correlate with aggravation and multiorgan damage in severe COVID-19
  Mingshan Xue, Yifeng Zeng, Hui-Qi Qu, Teng Zhang, Ning Li, Huimin Huang, Peiyan Zheng, Haisheng Hu, Luqian Zhou, Zhifeng Duan, Yong Zhang, Wei Bao, Li-feng Tian, Hakon Hakonarson, Nanshan Zhong, Xiaohua Douglas Zhang, Baoqing Sun
  
  ERJ Open Res 7: 00741-2020; DOI: 10.1183/23120541.00741-2020 Published 1 February 2021
- Open Access
  Chest radiography is a poor predictor of respiratory symptoms and functional impairment in survivors of severe COVID-19 pneumonia
  Rebecca F. D'Cruz, Michael D. Waller, Felicity Perrin, Jimstan Periselneris, Sam Norton, Laura-Jane Smith, Tanya Patrick, David Walder, Amadea Heitmann, Kai Lee, Rajiv Madula, William McNulty, Patricia Macedo, Rebecca Lyall, Geoffrey Warwick, James B. Galloway, Surinder S. Birring, Amit Patel, Irem Patel, Caroline J. Jolley
  
  ERJ Open Res 7: 00655-2020; DOI: 10.1183/23120541.00655-2020 Published 8 February 2021
- Open Access
  Underestimation of COVID-19 mortality during the pandemic
  Stacey Kung, Marjan Doppen, Melissa Black, Irene Braithwaite, Ciléin Kearns, Mark Weatherall, Richard Beasley, Nethmi Kearns
  
  ERJ Open Res 7: 00766-2020; DOI: 10.1183/23120541.00766-2020 Published 15 February 2021
- Open Access
  Self-proning in COVID-19 patients on low-flow oxygen therapy: a cluster randomised controlled trial
  Aileen Kharat, Elise Dupuis-Lozeron, Chloé Cantero, Christophe Marti, Olivier Grosgurin, Sanaz Lolachi, Frédéric Lador, Jérôme Plojoux, Jean-Paul Janssens, Paola M. Soccal, Dan Adler
  
  ERJ Open Res 7: 00692-2020; DOI: 10.1183/23120541.00692-2020 Published 8 March 2021
- Open Access
  Chest computed tomography and alveolar–arterial oxygen gradient as rapid tools to diagnose and triage mildly symptomatic COVID-19 pneumonia patients
  Marlise P. de Roos, Iris D. Kilsdonk, Pieter-Paul W. Hekking, Jan Peringa, Nynke G. Dijkstra, Peter W.A. Kunst, Paul Bresser, Herre J. Reesink
  
  ERJ Open Res 7: 00737-2020; DOI: 10.1183/23120541.00737-2020 Published 8 March 2021
- Open Access
  Conservative management of COVID-19 associated hypoxaemia
  Thomas Voshaar, Patrick Stais, Dieter Köhler, Dominic Dellweg
  
  ERJ Open Res 7: 00026-2021; DOI: 10.1183/23120541.00026-2021 Published 15 March 2021
Respiratory infections
- Open Access
  Longitudinal non-cystic fibrosis trends of pulmonary Mycobacterium abscessus disease from 2010 to 2017: spread of the “globally successful clone” in Asia
  Aristine Cheng, Hsin-Yun Sun, Yi-Tzu Tsai, Po-Liang Lu, Susan Shin-Jung Lee, Yi-Tzu Lee, Yung-Chih Wang, Po-Yu Liu, Jung-Yien Chien, Po-Ren Hsueh, Shu-Yuan Chang, Un-In Wu, Wang-Huei Sheng, Yee-Chun Chen, Shan-Chwen Chang
  
  ERJ Open Res 7: 00191-2020; DOI: 10.1183/23120541.00191-2020 Published 18 January 2021
- Open Access
  Statin use is associated with reduced mortality after respiratory viral infection
  Juan Antonio Franco-Peláez, Laura Esteban-Lucia, María de los Ángeles Zambrano Chacón, Ana María Pello-Lázaro, Ana María Venegas Rodriguez, Luis Nieto Roca, Camila Sofia García-Talavera, Andrea Kallmeyer Mayor, Felipe Villar Alvarez, Ricardo Fernandez Roblas, Oscar Gonzalez-Lorenzo, José Tuñón, Borja Ibañez, Alvaro Aceña
  
  ERJ Open Res 7: 00365-2020; DOI: 10.1183/23120541.00365-2020 Published 1 February 2021
- Open Access
  Early oseltamivir treatment improves survival in critically ill patients with influenza pneumonia
  Gerard Moreno, Alejandro Rodríguez, Jordi Sole-Violán, Ignacio Martín-Loeches, Emili Díaz, María Bodí, Luis F. Reyes, Josep Gómez, Juan Guardiola, Sandra Trefler, Loreto Vidaur, Elisabet Papiol, Lorenzo Socias, Carolina García-Vidal, Eudald Correig, Judith Marín-Corral, Marcos I. Restrepo, Jonathan S. Nguyen-Van-Tam, Antoni Torres
  
  ERJ Open Res 7: 00888-2020; DOI: 10.1183/23120541.00888-2020 Published 8 March 2021
- Open Access
  Chronic infection by nontypeable Haemophilus influenzae fuels airway inflammation
  Fabio Saliu, Giulia Rizzo, Alessandra Bragonzi, Lisa Cariani, Daniela M. Cirillo, Carla Colombo, Valeria Daccò, Daniela Girelli, Sara Rizzetto, Barbara Sipione, Cristina Cigana, Nicola I. Lorè
  
  ERJ Open Res 7: 00614-2020; DOI: 10.1183/23120541.00614-2020 Published 22 March 2021
- Open Access
  Association between body mass index and mortality in hospitalised patients with community-acquired pneumonia
  Richard Y. Kim, Connor Glick, Stephen Furmanek, Julio A. Ramirez, Rodrigo Cavallazzi
  
  ERJ Open Res 7: 00736-2020; DOI: 10.1183/23120541.00736-2020 Published 22 March 2021
Tuberculosis
- Open Access
  Collaborative tuberculosis/HIV activities in the European Region
  Gerard de Vries, Sarah van de Berg, Anke van Dam, Sayohat Hasanova, Manish Pareek, Marieke J. van der Werf, Daria N. Podlekareva
  
  ERJ Open Res 7: 00721-2020; DOI: 10.1183/23120541.00721-2020 Published 18 January 2021
- Open Access
  Outcomes with a shorter multidrug-resistant tuberculosis regimen from Karakalpakstan, Uzbekistan
  Philipp du Cros, Atadjan Khamraev, Zinaida Tigay, Tleubergen Abdrasuliev, Jane Greig, Graham Cooke, Krzysztof Herboczek, Tanya Pylypenko, Catherine Berry, Amrita Ronnachit, David Lister, Sebastian Dietrich, Cono Ariti, Khasan Safaev, Bern-Thomas Nyang'wa, Nargiza Parpieva, Mirzagalib Tillashaikhov, Jay Achar
  
  ERJ Open Res 7: 00537-2020; DOI: 10.1183/23120541.00537-2020 Published 8 February 2021
- Open Access
  The role of chest radiography in the diagnosis of bacteriologically confirmed pulmonary tuberculosis in hospitalised Xpert MTB/RIF-negative patients
  Wakjira Kebede, Gemeda Abebe, Esayas Kebede Gudina, Elias Kedir, Thuy Ngan Tran, Annelies Van Rie
  
  ERJ Open Res 7: 00708-2020; DOI: 10.1183/23120541.00708-2020 Published 22 March 2021
Cystic fibrosis
- Open Access
  Avatar acceptability: views from the Australian Cystic Fibrosis community on the use of personalised organoid technology to guide treatment decisions
  Laura K. Fawcett, Claire E. Wakefield, Sheila Sivam, Peter G. Middleton, Peter Wark, John Widger, Adam Jaffe, Shafagh A. Waters
  
  ERJ Open Res 7: 00448-2020; DOI: 10.1183/23120541.00448-2020 Published 18 January 2021
- Open Access
  Lumacaftor/ivacaftor-associated health stabilisation in adults with severe cystic fibrosis
  Susannah J. King, Dominic Keating, Elyssa Williams, Eldho Paul, Brigitte M. Borg, Felicity Finlayson, Brenda M. Button, John W. Wilson, Tom Kotsimbos
  
  ERJ Open Res 7: 00203-2020; DOI: 10.1183/23120541.00203-2020 Published 1 February 2021
- Open Access
  First clinical trials of the inhaled epithelial sodium channel inhibitor BI 1265162 in healthy volunteers
  Alison Mackie, Juliane Rascher, Marion Schmid, Verena Endriss, Tobias Brand, Wolfgang Seibold
  
  ERJ Open Res 7: 00447-2020; DOI: 10.1183/23120541.00447-2020 Published 1 February 2021
- Open Access
  Chest physiotherapy enhances detection of Pseudomonas aeruginosa in nonexpectorating children with cystic fibrosis
  Christophe Marguet, Véronique Houdouin, Isabelle Pin, Philippe Reix, Frédéric Huet, Marie Mittaine, Sophie Ramel, Nathalie Wizla-Derambure, Michel Abely, Marie-Laure Dalphin, Michael Fayon, Tiphaine Bihouée, Muriel Le Bourgeois, Eric Deneuville, Harriet Corvol, Muriel Laurans, Laure Couderc, Evelyne Leroux, Ludovic Lémée
  
  ERJ Open Res 7: 00513-2020; DOI: 10.1183/23120541.00513-2020 Published 8 March 2021
Primary ciliary dyskinesia
- Open Access
  CiliarMove: new software for evaluating ciliary beat frequency helps find novel mutations by a Portuguese multidisciplinary team on primary ciliary dyskinesia
  Pedro Sampaio, Mónica Ferro da Silva, Inês Vale, Mónica Roxo-Rosa, Andreia Pinto, Carolina Constant, Luisa Pereira, Carla M. Quintão, Susana S. Lopes
  
  ERJ Open Res 7: 00792-2020; DOI: 10.1183/23120541.00792-2020 Published 8 February 2021
Lung biology
- Open Access
  Extended lifespan of bronchial epithelial cells maintains normal cellular phenotype and transcriptome integrity
  Jonathan O'Loughlin, Robert J. Hall, Sangita Bhaker, Michael A. Portelli, Amanda Henry, Vincent Pang, David O. Bates, Tyson V. Sharp, Ian Sayers
  
  ERJ Open Res 7: 00254-2020; DOI: 10.1183/23120541.00254-2020 Published 18 January 2021
Critical care
- Open Access
  Validation of the Swedevox registry of continuous positive airway pressure, long-term mechanical ventilator and long-term oxygen therapy
  Magnus Ekström, Dirk Albrecht, Susanne Andersson, Ludger Grote, Birgitta Kärrsten Rundström, Andreas Palm, Jenny Theorell-Haglöw, Josefin Wahlberg, Bengt Midgren
  
  ERJ Open Res 7: 00340-2020; DOI: 10.1183/23120541.00340-2020 Published 18 January 2021
- Open Access
  Oesophageal pressure as a surrogate of pleural pressure in mechanically ventilated patients
  Antoine Tilmont, Benjamin Coiffard, Takeshi Yoshida, Florence Daviet, Karine Baumstarck, Geoffrey Brioude, Sami Hraiech, Jean-Marie Forel, Antoine Roch, Laurent Brochard, Laurent Papazian, Christophe Guervilly
  
  ERJ Open Res 7: 00646-2020; DOI: 10.1183/23120541.00646-2020 Published 8 March 2021
Smoking
- Open Access
  Losartan reduces cigarette smoke-induced airway inflammation and mucus hypersecretion
  Michael D. Kim, Nathalie Baumlin, John S. Dennis, Makoto Yoshida, Adrian Kis, Carolina Aguiar, Andreas Schmid, Eliana Mendes, Matthias Salathe
  
  ERJ Open Res 7: 00394-2020; DOI: 10.1183/23120541.00394-2020 Published 25 January 2021
COPD
- Open Access
  Endoscopic lung volume reduction with endobronchial valves in very low D_LCO patients: results from the German Registry – Lungenemphysemregister e.V.
  Pavlina Lenga, Christoph Ruwwe-Glösenkamp, Christian Grah, Joachim Pfannschmidt, Jens Rückert, Stephan Eggeling, Sven Gläser, Bernd Schmidt, Paul Schneider, Sylke Kurz, Gunda Leschber, Andreas Gebhardt, Birgit Becke, Olaf Schega, Jakob Borchardt, Ralf-Harto Hübner
  
  ERJ Open Res 7: 00449-2020; DOI: 10.1183/23120541.00449-2020 Published 25 January 2021
- Open Access
  Aerosol delivery aspects within a high-flow therapy system in COPD patients
  Yasmin M. Madney, Nabila Ibrahim Laz, Ahmed A. Elberry, Hoda Rabea, Mohamed E.A. Abdelrahim
  
  ERJ Open Res 7: 00422-2020; DOI: 10.1183/23120541.00422-2020 Published 25 January 2021
- Open Access
  Aspiration and severe exacerbations in COPD: a prospective study
  Lydia Cvejic, Nadine Guiney, Tiffany Nicholson, Kenneth K. Lau, Paul Finlay, Kais Hamza, Christian Osadnik, Paul Leong, Martin MacDonald, Paul T. King, Philip G. Bardin
  
  ERJ Open Res 7: 00735-2020; DOI: 10.1183/23120541.00735-2020 Published 25 January 2021
- Open Access
  Pleuroparenchymal fibroelastosis in Mycobacterium avium complex pulmonary disease: clinical characteristics and prognostic impact
  Yuji Yamamoto, Kazuyuki Tsujino, Tomoki Kuge, Fukuko Okabe, Takahiro Kawasaki, Takanori Matsuki, Hiroyuki Kagawa, Mari Miki, Keisuke Miki, Masahide Mori, Hiroshi Kida
  
  ERJ Open Res 7: 00765-2020; DOI: 10.1183/23120541.00765-2020 Published 1 February 2021
- Open Access
  Treatable cardiac disease in hospitalised COPD exacerbations
  Paul Leong, Martin I. MacDonald, Paul T. King, Christian R. Osadnik, Brian S. Ko, Shane A. Landry, Kais Hamza, Ahilan Kugenasan, John M. Troupis, Philip G. Bardin
  
  ERJ Open Res 7: 00756-2020; DOI: 10.1183/23120541.00756-2020 Published 8 February 2021
- Open Access
  Predictors of pulmonary rehabilitation completion in the UK
  Philip W. Stone, Katherine Hickman, Michael C. Steiner, C. Michael Roberts, Jennifer K. Quint, Sally J. Singh
  
  ERJ Open Res 7: 00509-2020; DOI: 10.1183/23120541.00509-2020 Published 8 February 2021
- Open Access
  Blood eosinophils on hospital admission for COPD exacerbation do not predict the recurrence of moderate and severe relapses
  Balázs Csoma, András Bikov, Ferenc Tóth, György Losonczy, Veronika Müller, Zsófia Lázár
  
  ERJ Open Res 7: 00543-2020; DOI: 10.1183/23120541.00543-2020 Published 8 February 2021
- Open Access
  Efficacy of indacaterol/glycopyrronium versus salmeterol/fluticasone in current and ex-smokers: a pooled analysis of IGNITE trials
  David M.G. Halpin, Claus F. Vogelmeier, Karen Mezzi, Pritam Gupta, Konstantinos Kostikas, Jadwiga A. Wedzicha
  
  ERJ Open Res 7: 00816-2020; DOI: 10.1183/23120541.00816-2020 Published 22 February 2021
- Open Access
  Cardiac biomarkers and long-term outcomes of exacerbations of COPD: a long-term follow-up of two cohorts
  Eskandarain Shafuddin, Sarah M. Fairweather, Catherina L. Chang, Christine Tuffery, Robert J. Hancox
  
  ERJ Open Res 7: 00531-2020; DOI: 10.1183/23120541.00531-2020 Published 22 February 2021
- Open Access
  Prognostic value of clinically important deterioration in COPD: IMPACT trial analysis
  MeiLan K. Han, Gerard J. Criner, Mark T. Dransfield, David M.G. Halpin, Christine E. Jones, Sally Kilbride, Peter Lange, Sally Lettis, David A. Lipson, David A. Lomas, Neil Martin, Fernando J. Martinez, Robert A. Wise, Ian P. Naya, Dave Singh
  
  ERJ Open Res 7: 00663-2020; DOI: 10.1183/23120541.00663-2020 Published 8 March 2021
- Open Access
  The presence of emphysema on chest imaging and mid-life cognition
  Benjamin E. Henkle, Laura A. Colangelo, Mark T. Dransfield, Lifang Hou, David R. Jacobs, Brian T. Joyce, Carrie L. Pistenmaa, Rachel K. Putman, Steve Sidney, Bharat Thyagarajan, George R. Washko, Kristine Yaffe, Ravi Kalhan, Ken M. Kunisaki
  
  ERJ Open Res 7: 00048-2021; DOI: 10.1183/23120541.00048-2021 Published 15 March 2021
- Open Access
  Cost-effectiveness analysis of a single-inhaler triple therapy for COPD in the UK
  Elisabeth Fenwick, Alan Martin, Melanie Schroeder, Stuart J. Mealing, Oyinkansola Solanke, Nancy Risebrough, Afisi S. Ismaila
  
  ERJ Open Res 7: 00480-2020; DOI: 10.1183/23120541.00480-2020 Published 22 March 2021
- Open Access
  Central airway and peripheral lung structures in airway disease-dominant COPD
  Naoya Tanabe, Kaoruko Shimizu, Kunihiko Terada, Susumu Sato, Masaru Suzuki, Hiroshi Shima, Akira Oguma, Tsuyoshi Oguma, Satoshi Konno, Masaharu Nishimura, Toyohiro Hirai
  
  ERJ Open Res 7: 00672-2020; DOI: 10.1183/23120541.00672-2020 Published 22 March 2021
- Open Access
  Proteomics of serum extracellular vesicles identifies a novel COPD biomarker, fibulin-3 from elastic fibres
  Taro Koba, Yoshito Takeda, Ryohei Narumi, Takashi Shiromizu, Yosui Nojima, Mari Ito, Muneyoshi Kuroyama, Yu Futami, Takayuki Takimoto, Takanori Matsuki, Ryuya Edahiro, Satoshi Nojima, Yoshitomo Hayama, Kiyoharu Fukushima, Haruhiko Hirata, Shohei Koyama, Kota Iwahori, Izumi Nagatomo, Mayumi Suzuki, Yuya Shirai, Teruaki Murakami, Kaori Nakanishi, Takeshi Nakatani, Yasuhiko Suga, Kotaro Miyake, Takayuki Shiroyama, Hiroshi Kida, Takako Sasaki, Koji Ueda, Kenji Mizuguchi, Jun Adachi, Takeshi Tomonaga, Atsushi Kumanogoh
  
  ERJ Open Res 7: 00658-2020; DOI: 10.1183/23120541.00658-2020 Published 22 March 2021
- Open Access
  Mechanisms associated with increased physical activity in patients undergoing self-management behaviour modification in the randomised PHYSACTO trial
  Jean Bourbeau, Maria Sedeno, Pei Zhi Li, Thierry Troosters, Alan Hamilton, Dorothy De Sousa, François Maltais, Damijan Erzen, Kim L. Lavoie
  
  ERJ Open Res 7: 00533-2020; DOI: 10.1183/23120541.00533-2020 Published 29 March 2021
- Open Access
  A double-blind randomised controlled trial of protein supplementation to enhance exercise capacity in COPD during pulmonary rehabilitation: a pilot study
  Abdulelah M. Aldhahir, Yousef S. Aldabayan, Jaber S. Alqahtani, Heidi A. Ridsdale, Colette Smith, John R. Hurst, Swapna Mandal
  
  ERJ Open Res 7: 00077-2021; DOI: 10.1183/23120541.00077-2021 Published 29 March 2021
Asthma and COPD
- You have accessRestricted access
  Validation of a diagnosis-agnostic symptom questionnaire for asthma and/or COPD
  Niklas Karlsson, Mark J. Atkinson, Hana Müllerová, Marianna Alacqua, Christina Keen, Rod Hughes, Christer Janson, Barry Make, David Price, Helen K. Reddel
  
  ERJ Open Res 7: 00828-2020; DOI: 10.1183/23120541.00828-2020 Published 1 February 2021
Asthma
- Open Access
  ICS-formoterol reliever versus ICS and short-acting β₂-agonist reliever in asthma: a systematic review and meta-analysis
  Lee Hatter, Pepa Bruce, Irene Braithwaite, Mark Holliday, James Fingleton, Mark Weatherall, Richard Beasley
  
  ERJ Open Res 7: 00701-2020; DOI: 10.1183/23120541.00701-2020 Published 25 January 2021
- Open Access
  Bronchodilator reversibility as a diagnostic test for adult asthma: findings from the population-based Tasmanian Longitudinal Health Study
  Daniel J. Tan, Caroline J. Lodge, Adrian J. Lowe, Dinh S. Bui, Gayan Bowatte, David P. Johns, Garun S. Hamilton, Paul S. Thomas, Michael J. Abramson, E. Haydn Walters, Jennifer L. Perret, Shyamali C. Dharmage
  
  ERJ Open Res 7: 00042-2020; DOI: 10.1183/23120541.00042-2020 Published 8 February 2021
- Open Access
  Long-term adherence to inhaled corticosteroids and asthma control in adult-onset asthma
  Iida Vähätalo, Hannu Kankaanranta, Leena E. Tuomisto, Onni Niemelä, Lauri Lehtimäki, Pinja Ilmarinen
  
  ERJ Open Res 7: 00715-2020; DOI: 10.1183/23120541.00715-2020 Published 8 February 2021
- Open Access
  Respiratory subtype of relapsing polychondritis frequently presents as difficult asthma: a descriptive study of respiratory involvement in relapsing polychondritis with 13 patients from a single UK centre
  Shirish Dubey, Colin Gelder, Grace Pink, Asad Ali, Christopher Taylor, Joanna Shakespeare, Susan Townsend, Patrick Murphy, Nicholas Hart, David D'Cruz
  
  ERJ Open Res 7: 00170-2020; DOI: 10.1183/23120541.00170-2020 Published 15 February 2021
- Open Access
  Antibiotic use in children and youths with asthma: a population-based case-control study
  Ivy Fong, Jingqin Zhu, Yaron Finkelstein, Teresa To
  
  ERJ Open Res 7: 00944-2020; DOI: 10.1183/23120541.00944-2020 Published 15 March 2021
- Open Access
  Differences in nitric oxide airway diffusion after maximum oxygen uptake test in asthmatic and nonasthmatic elite junior cross-country skiers
  Marieann Högman, Lars Wedholm, Tomas Carlsson, Magnus Carlsson, Michail Tonkonogi
  
  ERJ Open Res 7: 00378-2020; DOI: 10.1183/23120541.00378-2020 Published 15 March 2021
- Open Access
  The economics of precision health: preventing air pollution-induced exacerbation in asthma
  Tima Mohammadi, Mohsen Sadatsafavi, Chris Carlsten
  
  ERJ Open Res 7: 00790-2020; DOI: 10.1183/23120541.00790-2020 Published 22 March 2021
- Open Access
  What matters to people with severe asthma? Exploring add-on asthma medication and outcomes of importance
  Vanessa L. Clark, Peter G. Gibson, Vanessa M. McDonald
  
  ERJ Open Res 7: 00497-2020; DOI: 10.1183/23120541.00497-2020 Published 29 March 2021
Airway diseases
- Open Access
  Sarcopenia in older people with chronic airway diseases: the Rotterdam study
  Elizabeth Benz, Katerina Trajanoska, Josje D. Schoufour, Lies Lahousse, Emmely W. de Roos, Natalie Terzikhan, Carolina Medina-Gomez, Katia Verhamme, Ross Williams, Bruno H. Stricker, Oscar H. Franco, M. Arfan Ikram, Fernando Rivadeneira, Guy Brusselle
  
  ERJ Open Res 7: 00522-2020; DOI: 10.1183/23120541.00522-2020 Published 8 March 2021
Lung cancer
- Open Access
  High sensitivity of PD-L1 analysis from pleural effusion in nonsmall cell lung cancer
  Lars Hagmeyer, Stephan Schäfer, Marianne Engels, Anja Pietzke-Calcagnile, Marcel Treml, Simon-Dominik Herkenrath, Matthias Heldwein, Khosro Hekmat, Sandhya Matthes, Andreas Scheel, Jürgen Wolf, Reinhard Büttner, Winfried Randerath
  
  ERJ Open Res 7: 00787-2020; DOI: 10.1183/23120541.00787-2020 Published 22 March 2021
Lung cancer and IPF
- Open Access
  The DIAMORFOSIS (DIAgnosis and Management Of lung canceR and FibrOSIS) survey: international survey and call for consensus
  Argyris Tzouvelekis, Katerina Antoniou, Michael Kreuter, Matthew Evison, Torsten G. Blum, Venerino Poletti, Bogdan Grigoriu, Carlo Vancheri, Paolo Spagnolo, Theodoros Karampitsakos, Francesco Bonella, Athol Wells, Ganesh Raghu, Maria Molina-Molina, Daniel A. Culver, Elisabeth Bendstrup, Nesrin Mogulkoc, Stefano Elia, Jacques Cadranel, Demosthenes Bouros
  
  ERJ Open Res 7: 00529-2020; DOI: 10.1183/23120541.00529-2020 Published 25 January 2021
Interstitial lung disease
- Open Access
  Idiopathic pulmonary fibrosis in the UK: analysis of the British Thoracic Society electronic registry between 2013 and 2019
  Lisa G. Spencer, Maria Loughenbury, Nazia Chaudhuri, Monica Spiteri, Helen Parfrey
  
  ERJ Open Res 7: 00187-2020; DOI: 10.1183/23120541.00187-2020 Published 25 January 2021
- Open Access
  Pharmacological and nonpharmacological interventions to improve symptom control, functional exercise capacity and quality of life in interstitial lung disease: an evidence synthesis
  Sabrina Bajwah, Jill Colquitt, Emma Loveman, Claudia Bausewein, Howard Almond, Adejoke Oluyase, Mendy Dzingina, Matthew Maddocks, Irene J. Higginson, Athol Wells
  
  ERJ Open Res 7: 00107-2020; DOI: 10.1183/23120541.00107-2020 Published 25 January 2021
- Open Access
  Indications and patterns of use of benzodiazepines and opioids in severe interstitial lung disease: a population-based longitudinal study
  Jenny Genberg, Joanna M. Davies, Zainab Ahmadi, David Currow, Miriam J. Johnson, Hanan Tanash, Sabrina Bajwah, Magnus Ekström
  
  ERJ Open Res 7: 00716-2020; DOI: 10.1183/23120541.00716-2020 Published 1 February 2021
- Open Access
  Treatment with antifibrotic agents in idiopathic pleuroparenchymal fibroelastosis with usual interstitial pneumonia
  Keishi Sugino, Hirotaka Ono, Hiroshige Shimizu, Takeyuki Kurosawa, Keiko Matsumoto, Masahiro Ando, Kiyoshi Mori, Eiyasu Tsuboi, Sakae Homma, Kazuma Kishi
  
  ERJ Open Res 7: 00196-2020; DOI: 10.1183/23120541.00196-2020 Published 1 March 2021
- Open Access
  Distinct immune regulatory receptor profiles linked to altered monocyte subsets in sarcoidosis
  Simon D. Fraser, Michael G. Crooks, Paul M. Kaye, Simon P. Hart
  
  ERJ Open Res 7: 00804-2020; DOI: 10.1183/23120541.00804-2020 Published 15 March 2021
- Open Access
  Presence of Propionibacterium acnes in granulomas associates with a chronic disease course in Dutch sarcoidosis patients
  Els Beijer, Kees Seldenrijk, Yoshinobu Eishi, Keisuke Uchida, Jan Damen, Jan C. Grutters, Marcel Veltkamp
  
  ERJ Open Res 7: 00486-2020; DOI: 10.1183/23120541.00486-2020 Published 22 March 2021
- Open Access
  Prevalence and characteristics of self-reported hypothyroidism and its association with nonorgan-specific manifestations in US sarcoidosis patients: a nationwide registry study
  Bashar N. Alzghoul, Farah N. Amer, Diana Barb, Ayoub Innabi, Mamoun T. Mardini, Chen Bai, Bara Alzghoul, Tamara Al-Hakim, Noopur Singh, Mindy Buchanan, Leslie Serchuck, Diana Gomez Manjarres, Whitney W. Woodmansee, Lisa A. Maier, Divya C. Patel
  
  ERJ Open Res 7: 00754-2020; DOI: 10.1183/23120541.00754-2020 Published 29 March 2021
Pulmonary vascular disease
- Open Access
  Response to exercise in patients with pulmonary arterial hypertension treated with combination therapy
  Mari Nishizaki, Aiko Ogawa, Hiromi Matsubara
  
  ERJ Open Res 7: 00725-2020; DOI: 10.1183/23120541.00725-2020 Published 25 January 2021
- Open Access
  Direct oral anticoagulant therapy in patients with morbid obesity after intermediate- or high-risk pulmonary emboli
  Daniel J. Lachant, Christina Bach, Alexander Fe, R. James White, Neil A. Lachant
  
  ERJ Open Res 7: 00554-2020; DOI: 10.1183/23120541.00554-2020 Published 1 February 2021
- Open Access
  Pulmonary hypertension in eosinophilic versus noneosinophilic COPD
  Bashar N. Alzghoul, Mohammad As Sayaideh, Brian F. Moreno, Saminder K. Singh, Ayoub Innabi, Raju Reddy, Eric S. Papierniak, Hassan M Alnuaimat
  
  ERJ Open Res 7: 00772-2020; DOI: 10.1183/23120541.00772-2020 Published 8 March 2021
Mechanical ventilation
- Open Access
  Non-interventional monitoring of expiratory flow limitation during experimental mechanical ventilation
  Giorgos Marinakis, Michael Paraschos, Maria Patrani, Theodoros Tsoutsouras, Miltos Vassiliou
  
  ERJ Open Res 7: 00264-2020; DOI: 10.1183/23120541.00264-2020 Published 25 January 2021
Lung transplantation
- Open Access
  Donor-derived, cell-free DNA levels by next-generation targeted sequencing are elevated in allograft rejection after lung transplantation
  Kiran K. Khush, Iwijn De Vlaminck, Helen Luikart, David J. Ross, Mark R. Nicolls
  
  ERJ Open Res 7: 00462-2020; DOI: 10.1183/23120541.00462-2020 Published 25 January 2021
- Open Access
  Near-normal aerobic capacity in long-term survivors after lung transplantation
  Berta Saez-Gimenez, Miriam Barrecheguren, Maria Antònia Ramon, Alba Gomez-Garrido, Carlos Bravo, Víctor Monforte, Manuel López-Meseguer, Cristina Berastegui, Eva Revilla, Christian Romero, Rosalía Laporta, Sonia Fernández-Rozas, Javier Redel-Montero, Amparo Solé, Mercedes de la Torre, Luis Puente, Antonio Roman, Susana Gómez-Ollés, Iñigo Ojanguren
  
  ERJ Open Res 7: 00381-2020; DOI: 10.1183/23120541.00381-2020 Published 1 February 2021
Lung function
- Open Access
  The impact of changing to the Global Lung Function Initiative reference equations for transfer factor in paediatrics
  Paul D. Burns, James Y. Paton
  
  ERJ Open Res 7: 00412-2020; DOI: 10.1183/23120541.00412-2020 Published 25 January 2021
- Open Access
  Controlled versus free breathing for multiple breath nitrogen washout in healthy adults
  Blake M. Handley, Edward Jeagal, Robin E. Schoeffel, Tanya Badal, David G. Chapman, Catherine E. Farrow, Gregory G. King, Paul D. Robinson, Stephen Milne, Cindy Thamrin
  
  ERJ Open Res 7: 00435-2020; DOI: 10.1183/23120541.00435-2020 Published 25 January 2021
- Open Access
  Pulmonary function tests in type 2 diabetes: a meta-analysis
  Jesús Díez-Manglano, Uxua Asìn Samper
  
  ERJ Open Res 7: 00371-2020; DOI: 10.1183/23120541.00371-2020 Published 1 February 2021
- Open Access
  Improving spirometry testing by understanding patient preferences
  Barbara Johnson, Irene Steenbruggen, Brian L. Graham, Courtney Coleman
  
  ERJ Open Res 7: 00712-2020; DOI: 10.1183/23120541.00712-2020 Published 8 February 2021
- Open Access
  Reliability of maximum oxygen uptake in cardiopulmonary exercise testing with continuous laryngoscopy
  Mette Engan, Ida Jansrud Hammer, Marianne Bekken, Thomas Halvorsen, Zoe Louise Fretheim-Kelly, Maria Vollsæter, Lars Peder Vatshelle Bovim, Ola Drange Røksund, Hege Clemm
  
  ERJ Open Res 7: 00825-2020; DOI: 10.1183/23120541.00825-2020 Published 15 February 2021
- Open Access
  Epigenome-wide association study on diffusing capacity of the lung
  Natalie Terzikhan, Hanfei Xu, Ahmed Edris, Ken R. Bracke, Fien M. Verhamme, Bruno H.C. Stricker, Josée Dupuis, Lies Lahousse, George T. O'Connor, Guy G. Brusselle
  
  ERJ Open Res 7: 00567-2020; DOI: 10.1183/23120541.00567-2020 Published 15 March 2021
- Open Access
  A 10-year follow-up of key gas exchange exercise parameters in a general population: results of the Study of Health in Pomerania
  Beate Stubbe, Till Ittermann, Sabine Kaczmarek, Anne Obst, Martin Bahls, Tom Bollmann, Sven Gläser, Henry Völzke, Marcus Dörr, Ralf Ewert
  
  ERJ Open Res 7: 00350-2020; DOI: 10.1183/23120541.00350-2020 Published 22 March 2021
- Open Access
  Respiratory impedance measured using impulse oscillometry in a healthy urban population
  Kenneth I. Berger, Margaret Wohlleber, Roberta M. Goldring, Joan Reibman, Mark R. Farfel, Stephen M. Friedman, Beno W. Oppenheimer, Steven D. Stellman, James E. Cone, Yongzhao Shao
  
  ERJ Open Res 7: 00560-2020; DOI: 10.1183/23120541.00560-2020 Published 29 March 2021
Neuromuscular disorders
- Open Access
  Unilateral diaphragmatic paralysis: inspiratory muscles, breathlessness and exercise capacity
  Mayra Caleffi Pereira, Letícia Z. Cardenas, Jeferson G. Ferreira, Vinícius C. Iamonti, Pauliane Vieira Santana, André Apanavicius, Pedro Caruso, Angelo Fernandez, Carlos R.R. de Carvalho, Daniel Langer, André L.P. de Albuquerque
  
  ERJ Open Res 7: 00357-2019; DOI: 10.1183/23120541.00357-2019 Published 1 February 2021
Lung imaging
- Open Access
  Lung ultrasound patterns in paediatric pneumonia in Mozambique and Pakistan
  Amy Sarah Ginsburg, Pio Vitorino, Zunera Qasim, Jennifer L. Lenahan, Jun Hwang, Alessandro Lamorte, Marta Valente, Benazir Balouch, Carmen Muñoz Almagro, M. Imran Nisar, Susanne May, Fyezah Jehan, Quique Bassat, Giovanni Volpicelli
  
  ERJ Open Res 7: 00518-2020; DOI: 10.1183/23120541.00518-2020 Published 1 February 2021
- Open Access
  Diaphragmatic motion recorded by M-mode ultrasonography: limits of normality
  Alain Boussuges, Julie Finance, Guillaume Chaumet, Fabienne Brégeon
  
  ERJ Open Res 7: 00714-2020; DOI: 10.1183/23120541.00714-2020 Published 22 March 2021
Sleep
- Open Access
  Feasibility of three-dimensional facial imaging and printing for producing customised nasal masks for continuous positive airway pressure
  Kelvin Duong, Joel Glover, Alexander C. Perry, Deborah Olmstead, Mark Ungrin, Pina Colarusso, Joanna E. MacLean, Andrew R. Martin
  
  ERJ Open Res 7: 00632-2020; DOI: 10.1183/23120541.00632-2020 Published 1 February 2021
- Open Access
  Evaluation of a multicomponent grading system for obstructive sleep apnoea: the Baveno classification
  Winfried J. Randerath, Simon Herkenrath, Marcel Treml, Ludger Grote, Jan Hedner, Maria Rosaria Bonsignore, Jean Louis Pépin, Silke Ryan, Sophia Schiza, Johan Verbraecken, Walter T. McNicholas, Athanasia Pataka, Pawel Sliwinski, Özen K. Basoglu
  
  ERJ Open Res 7: 00928-2020; DOI: 10.1183/23120541.00928-2020 Published 1 March 2021
Basic science
- Open Access
  Development and validation of an open-source, disposable, 3D-printed in vitro environmental exposure system for Transwell culture inserts
  Abiram Chandiramohan, Mohammedhossein Dabaghi, Jennifer A. Aguiar, Nicholas Tiessen, Mary Stewart, Quynh T. Cao, Jenny P. Nguyen, Nima Makhdami, Gerard Cox, Andrew C. Doxey, Jeremy A. Hirota
  
  ERJ Open Res 7: 00705-2020; DOI: 10.1183/23120541.00705-2020 Published 15 February 2021
Cough
- Open Access
  Characterisation of cough evoked by inhaled treprostinil and treprostinil palmitil
  Richard W. Chapman, Michel R. Corboz, Carlos Fernandez, Eugene Sullivan, Andy Stautberg, Adam J. Plaunt, Donna M. Konicek, Vladimir Malinin, Zhili Li, David Cipolla, Walter Perkins
  
  ERJ Open Res 7: 00592-2020; DOI: 10.1183/23120541.00592-2020 Published 15 February 2021
- Open Access
  Is laryngeal hypersensitivity the basis of unexplained or refractory chronic cough?
  Krishna M. Sundar, Amanda Carole Stark, Nan Hu, Julie Barkmeier-Kraemer
  
  ERJ Open Res 7: 00793-2020; DOI: 10.1183/23120541.00793-2020 Published 29 March 2021
Clinical practice
- Open Access
  A syndromic approach to assess diagnosis and management of patients presenting with respiratory symptoms to healthcare facilities in Vietnam
  Wan-Chun Huang, Gregory J. Fox, Ngoc Yen Pham, Thu Anh Nguyen, Van Giap Vu, Quy Chau Ngo, Viet Nhung Nguyen, Stephen Jan, Joel Negin, Thi Tuyet Lan Le, Guy B. Marks
  
  ERJ Open Res 7: 00572-2020; DOI: 10.1183/23120541.00572-2020 Published 1 March 2021

Original research letters

Open Access
Higher interleukin-6 levels and changes in transforming growth factor-β are associated with lung impairment in pulmonary tuberculosis
Akshay N. Gupte, Sriram Selvaraju, Sanjay Gaikwad, Vidya Mave, Pavan Kumar, Subash Babu, Bruno B. Andrade, William Checkley, Robert Bollinger, Amita Gupta

ERJ Open Res 7: 00390-2020; DOI: 10.1183/23120541.00390-2020 Published 18 January 2021
Open Access
The six million dollar man
Mathilde Volpato, Stefan Nowak, Jean Luc Bourrain, Pascal Demoly, Engi Ahmed, Arnaud Bourdin, Jeremy Charriot

ERJ Open Res 7: 00341-2020; DOI: 10.1183/23120541.00341-2020 Published 18 January 2021
Open Access
Pulmonary hypertension in hereditary haemorrhagic telangiectasia is associated with multiple clinical conditions
Victor Margelidon-Cozzolino, Vincent Cottin, Sophie Dupuis-Girod, Julie Traclet, Kais Ahmad, Jean-François Mornex, Ségolène Turquier

ERJ Open Res 7: 00078-2020; DOI: 10.1183/23120541.00078-2020 Published 25 January 2021
Open Access
Newly developed multiple-breath washout reference equations from the CHILD Cohort Study: implications of poorly fitting equations
Zihang Lu, Ruixue Dai, Krzysztof Kowalik, Aimee Dubeau, Diana L. Lefebvre, Susan Balkovec, Allan B. Becker, Piush J. Mandhane, Stuart E. Turvey, Wendy Lou, Felix Ratjen, Theo J. Moraes, Malcolm R. Sears, Per M. Gustafsson, Padmaja Subbarao

ERJ Open Res 7: 00301-2020; DOI: 10.1183/23120541.00301-2020 Published 25 January 2021
Open Access
Pre-COVID-19 lung function and other risk factors for severe COVID-19 in first responders
Michael D. Weiden, Rachel Zeig-Owens, Ankura Singh, Theresa Schwartz, Yang Liu, Brandon Vaeth, Anna Nolan, Krystal L. Cleven, Karen Hurwitz, Shenecia Beecher, David J. Prezant

ERJ Open Res 7: 00610-2020; DOI: 10.1183/23120541.00610-2020 Published 25 January 2021
Open Access
Endoscopic transoesophageal fine-needle aspiration with convex probe bronchoscope for diagnosis of coeliac lymphadenopathy
Manu Juneja, Louis P. Irving, Daniel P. Steinfort

ERJ Open Res 7: 00532-2020; DOI: 10.1183/23120541.00532-2020 Published 25 January 2021
Open Access
Performance and safety of diagnostic procedures in superior vena cava syndrome
Catherine Boily-Daoust, Alexandre Plante, Cedrick Adam, Marc Fortin

ERJ Open Res 7: 00392-2020; DOI: 10.1183/23120541.00392-2020 Published 25 January 2021
Open Access
Is asthma a risk factor for COVID-19? Are phenotypes important?
Xavier Muñoz, Florencia Pilia, Iñigo Ojanguren, Christian Romero-Mesones, María-Jesús Cruz

ERJ Open Res 7: 00216-2020; DOI: 10.1183/23120541.00216-2020 Published 25 January 2021
Open Access
Higher body mass index is associated with increased lung stiffness and less airway obstruction in individuals with asthma and fixed airflow obstruction
Sandra Rutting, David G. Chapman, Tanya Badal, Farid Sanai, Sabine C. Zimmermann, Cindy Thamrin, Gregory G. King, Katrina O. Tonga

ERJ Open Res 7: 00336-2020; DOI: 10.1183/23120541.00336-2020 Published 25 January 2021
Open Access
Challenges in understanding host genetics and severity of community-acquired pneumonia
Jordi Solé-Violán, Elisa Hernández-Brito, José Manuel Valencia-Gallardo, Estefanía Herrera-Ramos, Luis Borderías, M. Luisa Briones, Olga Rajas, Jorge Freixinet, Leonardo Lorente, Antoni Payeras, José Ferreres, Nieves Carbonell, Nereida González-Quevedo, Jesús M. González-Martín, Felipe Rodríguez de Castro, Carlos Rodríguez-Gallego

ERJ Open Res 7: 00745-2020; DOI: 10.1183/23120541.00745-2020 Published 25 January 2021
Open Access
Placing a mask on COVID-19 patients during high-flow nasal cannula therapy reduces aerosol particle dispersion
Jie Li, James B. Fink, Ahmad A. Elshafei, Laurel M. Stewart, Hannah J. Barbian, Sara H. Mirza, Lena Al-Harthi, David Vines, Stephan Ehrmann

ERJ Open Res 7: 00519-2020; DOI: 10.1183/23120541.00519-2020 Published 25 January 2021
Open Access
Soft cervical collar in obstructive sleep apnoea: a pilot study
Philippe Bordier, Aurélia Lataste, Sébastien Orazio, Jérémy Papin, Frédéric Robert, Ghalia Bourenane

ERJ Open Res 7: 00431-2020; DOI: 10.1183/23120541.00431-2020 Published 25 January 2021
Open Access
The impact of the first COVID-19 surge on severe asthma patients in the UK. Which is worse: the virus or the lockdown?
Steven J. Smith, John Busby, Liam G. Heaney, Paul E. Pfeffer, David J. Jackson, Freda Yang, Stephen J. Fowler, Andrew Menzies-Gow, Elfatih Idris, Thomas Brown, Robin Gore, Shoaib Faruqi, Paddy Dennison, James W. Dodd, Simon Doe, Adel H. Mansur, Radhika Priyadarshi, Joshua Holmes, Andrew Hearn, Hamsa Al-Aqqad, Lola Loewenthal, Angela Cooper, Lauren Fox, Mayurun Selvan, Michael G. Crooks, Alison Thompson, Daniel Higbee, Michelle Fawdon, Vishal Nathwani, LeanneJo Holmes, Rekha Chaudhuri

ERJ Open Res 7: 00768-2020; DOI: 10.1183/23120541.00768-2020 Published 1 February 2021
Open Access
Impact of COVID-19 on COPD and asthma admissions, and the pandemic from a patient's perspective
Dominic L. Sykes, Shoaib Faruqi, Luke Holdsworth, Michael G. Crooks

ERJ Open Res 7: 00822-2020; DOI: 10.1183/23120541.00822-2020 Published 8 February 2021
Open Access
The role of high-flow nasal therapy in bronchiectasis: a post hoc analysis
William R. Good, Jeffrey Garrett, Hans U.P. Hockey, Lata Jayaram, Conroy Wong, Harold Rea

ERJ Open Res 7: 00711-2020; DOI: 10.1183/23120541.00711-2020 Published 8 February 2021
Open Access
What is important for people with nontuberculous mycobacterial disease? An EMBARC-ELF patient survey
Michal Shteinberg, Jeanette Boyd, Stefano Aliberti, Eva Polverino, Bridget Harris, Tove Berg, Annette Posthumus, Thomas Ruddy, Pieter Goeminne, Ernie Lloyd, Timothy Alan, Josje Altenburg, Barbara Crossley, Francesco Blasi, James Chalmers

ERJ Open Res 7: 00807-2020; DOI: 10.1183/23120541.00807-2020 Published 15 February 2021
Open Access
Duration of rheumatoid arthritis and the risk of developing interstitial lung disease
Michael P. Mohning, Isabelle Amigues, M. Kristen Demoruelle, Evans R. Fernández Pérez, Tristan J. Huie, Rebecca K. Keith, Amy L. Olson, Zulma X. Yunt, Jonathan H. Chung, Stephen Hobbs, Jeffrey J. Swigris, Joshua J. Solomon

ERJ Open Res 7: 00633-2020; DOI: 10.1183/23120541.00633-2020 Published 22 February 2021
Open Access
Prevalence of stress urinary incontinence in women presenting for evaluation of chronic cough
Peter V. Dicpinigaitis

ERJ Open Res 7: 00012-2021; DOI: 10.1183/23120541.00012-2021 Published 22 February 2021
Open Access
Thrombolysis for massive pulmonary embolisms in morbid obesity: a multisite case–control study
Chinthaka B. Samaranayake, Gregory Keir, Colm McCabe, James Anderson, Khoa Tran, John W. Upham

ERJ Open Res 7: 00762-2020; DOI: 10.1183/23120541.00762-2020 Published 1 March 2021
Open Access
The effect of physical activity on asthma incidence over 10 years: population-based study
Melissa Anne Russell, Shyamali Dharmage, Elaine Fuertes, Alessandro Marcon, Anne-Elie Carsin, Silvia Pascual Erquicia, Joachim Heinrich, Ane Johannessen, Michael J. Abramson, Andre F.S. Amaral, Isa Cerveri, Pascal Demoly, Vanessa Garcia-Larsen, Deborah Jarvis, Jesus Martinez-Moratalla, Dennis Nowak, Leopoldo Palacios-Gomez, Giulia Squillacioti, Wasif Raza, Margareta Emtner, Judith Garcia-Aymerich

ERJ Open Res 7: 00970-2020; DOI: 10.1183/23120541.00970-2020 Published 1 March 2021
Open Access
Influence of ventilation inhomogeneity on diffusing capacity of carbon monoxide in smokers without COPD
Johanna Manuela Kurz, Jeannette Frey, Reto Auer, Nicolas Rodondi, Sylvia Nyilas, Nikolay Pavlov, Manuela Funke-Chambour, Florian Singer

ERJ Open Res 7: 00706-2020; DOI: 10.1183/23120541.00706-2020 Published 8 March 2021
Open Access
Patient-reported quality of life in fibrotic interstitial lung disease: novel assessments of self-management ability and affect
Teng Moua, Aahd Kubbara, Paul Novotny, Jennifer L. Ridgeway, Andrew H. Limper, Jay H. Ryu, Matthew M. Clark, Roberto Benzo

ERJ Open Res 7: 00011-2021; DOI: 10.1183/23120541.00011-2021 Published 8 March 2021
Open Access
Pulmonary infection caused by Mycobacterium marinum in a patient with anorexia nervosa
Kengo Oshima, Yukari Niinuma, Hajime Saito, Hiroaki Baba, Hajime Kanamori, Tetsuji Aoyagi, Koichi Tokuda, Mitsuo Kaku

ERJ Open Res 7: 00782-2020; DOI: 10.1183/23120541.00782-2020 Published 15 March 2021
Open Access
Increased blood angiotensin converting enzyme 2 activity in critically ill COVID-19 patients
Dirk van Lier, Matthijs Kox, Karine Santos, Hans van der Hoeven, Janesh Pillay, Peter Pickkers

ERJ Open Res 7: 00848-2020; DOI: 10.1183/23120541.00848-2020 Published 15 March 2021
Open Access
Contrasting haemodynamic effects of exercise and saline infusion in older adults with pulmonary arterial hypertension
Felipe H. Valle, Sam Esfandiari, Ho-Jun Jang, Felipe C. Fuchs, Stephen P. Wright, John Granton, Susanna Mak

ERJ Open Res 7: 00183-2020; DOI: 10.1183/23120541.00183-2020 Published 22 March 2021
Open Access
Mammomonogamus laryngeus: an unusual cause of acute and chronic cough in the Caribbean area
Moustapha Agossou, Sandy Jean-Baptiste, Ninon Ehret, Nicole Desbois-Nogard, Moustapha Drame, Nicolas Venissac

ERJ Open Res 7: 00814-2020; DOI: 10.1183/23120541.00814-2020 Published 22 March 2021
Open Access
Minimal clinically important difference for daily pedometer step count in COPD
Oliver Polgar, Suhani Patel, Jessica A. Walsh, Ruth E. Barker, Stuart F. Clarke, William D-C. Man, Claire M. Nolan

ERJ Open Res 7: 00823-2020; DOI: 10.1183/23120541.00823-2020 Published 22 March 2021
Open Access
Three-dimensional assessment of bronchiectasis in a mouse model of mucociliary clearance disorder
Willi Wagner, Christian Dullin, Stefan Andreas, Muriel Lizé

ERJ Open Res 7: 00635-2020; DOI: 10.1183/23120541.00635-2020 Published 29 March 2021
Open Access
Time on therapy and concomitant medication use of mepolizumab in Canada: a retrospective cohort study
Jason K. Lee, Alain Gendron, Michelle Knutson, Niroshan Sriskandarajah, Lawrence Mbuagbaw, Stephen G. Noorduyn

ERJ Open Res 7: 00778-2020; DOI: 10.1183/23120541.00778-2020 Published 29 March 2021
Open Access
A new KIF5B–ERBB4 gene fusion in a lung adenocarcinoma patient
Edouard Guenzi, Johan Pluvy, Alice Guyard, Marina Nguenang, Khedidja Rebah, Zoubida Benrahmoune, Jérome Lamoril, Aurelie Cazes, Valérie Gounant, Solenn Brosseau, Catherine Boileau, Gérard Zalcman, Nathalie Théou-Anton

ERJ Open Res 7: 00582-2020; DOI: 10.1183/23120541.00582-2020 Published 29 March 2021
Open Access
Comparison of forced oscillation technique and spirometry in paediatric asthma
Eero Lauhkonen, Georgios Kaltsakas, Sindhu Sivagnanasithiyar, Richard Iles

ERJ Open Res 7: 00202-2020; DOI: 10.1183/23120541.00202-2020 Published 29 March 2021
Open Access
Proteomic profiling of peripheral blood and bronchoalveolar lavage fluid in interstitial lung diseases: an explorative study
Sebastian Majewski, Xingwu Zhou, Joanna Miłkowska-Dymanowska, Adam J. Białas, Wojciech J. Piotrowski, Andrei Malinovschi

ERJ Open Res 7: 00489-2020; DOI: 10.1183/23120541.00489-2020 Published 29 March 2021

Correspondence

Open Access
Primary care and the COVID-19 pandemic: Schrödinger's cat
Emmanouil K Symvoulakis, Dimitrios Anyfantakis

ERJ Open Res 7: 00730-2020; DOI: 10.1183/23120541.00730-2020 Published 1 February 2021
Open Access
Conditional expanding post-exposure prophylaxis: a potential new tool for tuberculosis control
Henan Xin, Qi Jin, Lei Gao

ERJ Open Res 7: 00723-2020; DOI: 10.1183/23120541.00723-2020 Published 15 February 2021
Open Access
Interstitial lung disease-related pneumomediastinum in COVID-19 patients
Kim Blanc, Nicolas Bonnet, Elise Ouedraogo, Michel Arnaout, Maxime Patout, Yacine Tandjaoui-Lambiotte

ERJ Open Res 7: 00014-2021; DOI: 10.1183/23120541.00014-2021 Published 8 March 2021
Open Access
COVID-19 and complicated bacterial pneumonia in children
Mohamad Kaddour, Marcelle Simeonovic, Joshua Osowicki, Sarah McNab, Catherine Satzke, Colin Robertson, Cattram Nguyen, Sebastian King, Shivanthan Shanthikumar

ERJ Open Res 7: 00884-2020; DOI: 10.1183/23120541.00884-2020 Published 22 March 2021

Acknowledgement

Open Access
ERJ Open Research, list of peer reviewers 2020
ERJ Open Res 7: 10701-2021; DOI: 10.1183/23120541.10701-2021 Published 25 January 2021

Erratum

Open Access
“Steroid-sparing effects of benralizumab in patients with eosinophilic granulomatosis with polyangiitis” Alexandra M. Nanzer, Jaideep Dhariwal, Joanne Kavanagh, Andrew Hearn, Mariana Fernandes, Louise Thomson, Cris Roxas, Linda Green, Grainne D'Ancona, Sangita Agarwal, Brian D. Kent and David J. Jackson. ERJ Open Res 2019; 6: 00272-2019
ERJ Open Res 7: 50451-2020; DOI: 10.1183/23120541.50451-2020 Published 15 February 2021
Open Access
“Clinical experience with antifibrotics in fibrotic hypersensitivity pneumonitis: a 3-year real-life observational study” Vasilios Tzilas, Argyris Tzouvelekis, Evangelos Bouros, Theodoros Karampitsakos, Maria Ntassiou, Eleni Avdoula, Athena Trachalaki, Katerina Antoniou, Ganesh Raghu and Demosthenes Bouros. ERJ Open Res 2020; 6: 00152-2020.
ERJ Open Res 7: 50152-2020; DOI: 10.1183/23120541.50152-2020 Published 1 March 2021

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Table of Contents

Reviews

Congress highlights

Study protocol

Original articles

COVID-19

Respiratory infections

Tuberculosis

Cystic fibrosis

Primary ciliary dyskinesia

Lung biology

Critical care

Smoking

COPD

Asthma and COPD

Asthma

Airway diseases

Lung cancer

Lung cancer and IPF

Interstitial lung disease

Pulmonary vascular disease

Mechanical ventilation

Lung transplantation

Lung function

Neuromuscular disorders

Lung imaging

Sleep

Basic science

Cough

Clinical practice

Original research letters

Correspondence

Acknowledgement

Erratum

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