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Inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis

Aparna Iyer, Teodora Radonic, Lukas C. Heukamp, Erik Thunnissen, Johannes M.A. Daniels
ERJ Open Research 2021 7: 00151-2020; DOI: 10.1183/23120541.00151-2020
Aparna Iyer
1Dept of Pulmonary Medicine, Amsterdam University Medical Centre, Amsterdam, The Netherlands
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Teodora Radonic
2Dept of Pathology, Amsterdam University Medical Centre, Amsterdam, The Netherlands
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Lukas C. Heukamp
3Institute of Haematopathology Hamburg, Hamburg, Germany
4Lung Cancer Network NOWEL.org, Oldenburg, Germany
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Erik Thunnissen
2Dept of Pathology, Amsterdam University Medical Centre, Amsterdam, The Netherlands
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Johannes M.A. Daniels
1Dept of Pulmonary Medicine, Amsterdam University Medical Centre, Amsterdam, The Netherlands
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  • For correspondence: j.daniels@amsterdamumc.nl
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    FIGURE 1

    Bronchoscopic view a, c, e) before and b, d, f) after bronchoscopic resection of inflammatory myofibroblastic tumours.

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    FIGURE 2

    A representative overview and detail of inflammatory myofibroblastic tumour is shown. Haematoxylin and eosin stain a) 10× and b) 40×. c) Immunohistochemistry is positive in tumour cells for ALK (5A4 antibody, 20x), including the control appendix tissue showing negative myocytes and weakly positive ganglion cells (frame within panel (c)). d) Fluorescence in situ hybridisation analysis with an ALK rearrangement, note the split signals.

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Inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis
Aparna Iyer, Teodora Radonic, Lukas C. Heukamp, Erik Thunnissen, Johannes M.A. Daniels
ERJ Open Research Jan 2021, 7 (1) 00151-2020; DOI: 10.1183/23120541.00151-2020

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Inflammatory myofibroblastic tumour of the central airways: treatment and molecular analysis
Aparna Iyer, Teodora Radonic, Lukas C. Heukamp, Erik Thunnissen, Johannes M.A. Daniels
ERJ Open Research Jan 2021, 7 (1) 00151-2020; DOI: 10.1183/23120541.00151-2020
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