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Assessment of recent evidence for the management of patients with systemic sclerosis-associated interstitial lung disease: a systematic review

Anna-Maria Hoffmann-Vold, Toby M. Maher, Edward E. Philpot, Ali Ashrafzadeh, Oliver Distler
ERJ Open Research 2021 7: 00235-2020; DOI: 10.1183/23120541.00235-2020
Anna-Maria Hoffmann-Vold
1Dept of Rheumatology, Oslo University Hospital-Rikshospitalet, Oslo, Norway
7These authors contributed equally
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Toby M. Maher
2National Institute of Health Research Respiratory Clinical Research Facility, Royal Brompton Hospital, London, UK
3Fibrosis Research Group, National Heart and Lung Institute, Imperial College London, London, UK
7These authors contributed equally
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Edward E. Philpot
4Respiratory Center of Excellence, IQVIA, Durham, NC, USA
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Ali Ashrafzadeh
5Rheumatology Center of Excellence, IQVIA, San Diego, CA, USA
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Oliver Distler
6Dept of Rheumatology, University Hospital Zurich, Zurich, Switzerland
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    FIGURE 1

    Selection process of included publications (Preferred Reporting Items for Systematic Reviews and Meta-Analyses diagram).

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  • TABLE 1

    Critical appraisal of randomised controlled trials using National Institute for Health and Care Excellence standards#

    First author, year [ref.]RandomisationAllocation concealmentBlindingFollow-upSelective reportingStatistical analysis plan
    Tashkin, 2007 [12]YesUnclearYesNoNoUnclear
    Tashkin, 2016 [13]YesUnclearYesNoNoYes
    Sircar, 2017¶ [14]YesUnclearNoUnclearNoUnclear
    Pérez Campos, 2012 [15]YesYesYesNoNoUnclear
    Seibold, 2010 [16]UnclearUnclearYesNoNoUnclear

    #: a further study was underpowered and therefore not rated at the same evidence level [11]; ¶: please note that since the date of the literature search, this reference (abstract) has been published in full.

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      Supplementary material 00235-2020.SUPPLEMENT

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    Vol 7 Issue 1 Table of Contents
    ERJ Open Research: 7 (1)
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    Assessment of recent evidence for the management of patients with systemic sclerosis-associated interstitial lung disease: a systematic review
    Anna-Maria Hoffmann-Vold, Toby M. Maher, Edward E. Philpot, Ali Ashrafzadeh, Oliver Distler
    ERJ Open Research Jan 2021, 7 (1) 00235-2020; DOI: 10.1183/23120541.00235-2020

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    Assessment of recent evidence for the management of patients with systemic sclerosis-associated interstitial lung disease: a systematic review
    Anna-Maria Hoffmann-Vold, Toby M. Maher, Edward E. Philpot, Ali Ashrafzadeh, Oliver Distler
    ERJ Open Research Jan 2021, 7 (1) 00235-2020; DOI: 10.1183/23120541.00235-2020
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