Figures
- FIGURE 1
Correlations between peak oxygen uptake (V′O2peak) (% predicted) and a) forced expiratory volume in 1 s (FEV1) (% predicted), b) forced vital capacity (FVC) (% predicted), c) total lung capacity (TLC) (% predicted) and d) diffusing capacity of the lungs for carbon monoxide (DLCO) (% predicted).
- FIGURE 2
Correlations between maximum work rate (WRmax) (watts) and a) age, b) haemoglobin (Hb) and c) forced expiratory volume in 1 s (FEV1) (L).
- FIGURE 3
Adjusted predicted maximal oxygen uptake (V′O2max) values (and 95% confidence interval) against diffusing capacity of the lungs for carbon monoxide (DLCO).
- FIGURE 4
Adjusted predicted maximum work rate (WRmax) values (and 95% confidence interval) against haemoglobin (Hb).
Tables
- TABLE 1
Clinical characteristics of lung transplant (LT) recipients
Subjects n 29 Age years 48.7±13.6 Male sex n (%) 14 (48) Age at the time of LT years 34.7±14.0 Years since LT 14.0±3.1 Diagnosis COPD 3±10.3 ILD 4±13.7 CF 14±48.3 Bronchiectasis 1±3.5 PH 1±3.5 Other 6±20.7 BMI kg·m−2 21.6±5.6 FFMI kg·m−2 16.6±4.1 Haemoglobin g·dL−1 13.3±1.5 Arterial hypertension n (%) 15 (51.7) Diabetes mellitus n (%) 6 (20.7) Dyslipidaemia n (%) 11 (37.9) Smoking history n (%) Never smoked 21 (72.4) Former smoker 8 (27.6) Packs per year 29.7±23.4 Lung function FVC L 3.9±0.92 FVC % predicted 92.6±15.7 FEV1 L 3.1±0.7 FEV1 % predicted 97.9±14.5 DLCO (mL·mmHg−1·min−1) median (IQR) 77.1 (70–83.3) TLC % predicted 96.1±18.3 RV % predicted 81.0±8.5 Oral corticosteroids n (%) 28 (96.6) Oral corticosteroids dosage mg 3.9±1.6 Data are presented as mean±sd, unless otherwise stated. Some variables have missing values: eight in FFMI, one in packs per year and one in corticosteroid dosage. ILD: interstitial lung disease; CF: cystic fibrosis; PH: pulmonary hypertension; BMI: body mass index; FFMI: fat-free mass index; FVC: forced vital capacity; FEV1: forced expiratory volume in 1 s; DLCO: diffusing capacity of the lung for carbon monoxide; IQR: interquartile range; TLC: total lung capacity; RV: residual volume.
- TABLE 2
Exercise capacity, physical activity and quality of life of lung transplant (LT) recipients
Subjects n 29 V′O2 peak mL·kg−1·min−1 21.49±6.68 V′O2 peak % pred 75.24±15.6 V′O2 AT % 48.6±10.1 V′CO2 peak L·min−1 median (IQR) 1.68 (1.43–2.06) Work peak watts 111.14±37.13 V′E/V′CO2 AT 32 (31–35) V′E peak L·min−1 median (IQR) 54 (48–67.1) RER peak median (IQR) 1.35 (1.25–1.4) HR peak beats·min−1 141.5±21.4 HRR peak 17.5±13.6 V′O2/HR 90.5±19.4 VR peak median (IQR) 52 (48–57) Oximetry at V′O2 max % 97.6±0.8 Lactic acid peak mmol·L−1 7.35±1.89 IPAQ METs-min·week−1 median (IQR) 5497 (4007–9832) Euroqol 5-D 1 (0.95–1) Euroqol >0.8 29±100 Data are presented as mean±sd, unless otherwise stated.
V′O2: oxygen uptake; V′CO2: carbon dioxide output; IQR: interquartile range; AT: aerobic threshold; V′E: minute ventilation; RER: respiratory exchange ratio; HR: heart rate; HRR: heart rate reserve; VR: ventilator reserve; IPAQ: International Physical Activity Questionnaire.
- TABLE 3
Results of stepwise multiple regression analysis for maximal oxygen uptake (V′O2max) and maximum workload
V′O2max mL·kg−1·min−1 Maximum workload watts Coefficient (95% CI) p-value Coefficient (95% CI) p-value Age years −0.249 (−0.37–−0.13) <0.001 −0.24 (−1.17–0.69) 0.599 Male sex 5.35 (2.19–8.51) 0.002 4.72 (−34.75–25.30) 0.748 Haemoglobin g·dL−1 9.62 (2.21–17.02) 0.013 FEV1 L 31.53 (8.88–54.17) 0.008 DLCO % predicted 0.26 (0.15–0.36) <0.001 Constant 18.87 (16.80–20.95) <0.001 Adjusted R2 0.685 0.580 FEV1: forced expiratory volume in 1 s; DLCO: diffusing capacity of the lung for carbon monoxide.
