Skip to main content

Main menu

  • Home
  • Current issue
  • Early View
  • Archive
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • ERS Author FAQs
    • COVID-19 submission information
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • Early View
  • Archive
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • ERS Author FAQs
    • COVID-19 submission information
  • Alerts
  • Subscriptions

Near-normal aerobic capacity in long-term survivors after lung transplantation

Berta Saez-Gimenez, Miriam Barrecheguren, Maria Antònia Ramon, Alba Gomez-Garrido, Carlos Bravo, Víctor Monforte, Manuel López-Meseguer, Cristina Berastegui, Eva Revilla, Christian Romero, Rosalía Laporta, Sonia Fernández-Rozas, Javier Redel-Montero, Amparo Solé, Mercedes de la Torre, Luis Puente, Antonio Roman, Susana Gómez-Ollés, Iñigo Ojanguren
ERJ Open Research 2021 7: 00381-2020; DOI: 10.1183/23120541.00381-2020
Berta Saez-Gimenez
1Servicio de Neumología, Hospital Universitari Vall d'Hebron, Departamento de Medicina, Universidad Autónoma de Barcelona (UAB), Barcelona, Spain
10These authors contributed equally
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: bsaez@vhebron.net
Miriam Barrecheguren
1Servicio de Neumología, Hospital Universitari Vall d'Hebron, Departamento de Medicina, Universidad Autónoma de Barcelona (UAB), Barcelona, Spain
10These authors contributed equally
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maria Antònia Ramon
1Servicio de Neumología, Hospital Universitari Vall d'Hebron, Departamento de Medicina, Universidad Autónoma de Barcelona (UAB), Barcelona, Spain
2CIBER Enfermedades Respiratorias (CIBERES), Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Maria Antònia Ramon
Alba Gomez-Garrido
3Servicio de Rehabilitación, Hospital Universitario Vall d'Hebron, UAB, Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carlos Bravo
1Servicio de Neumología, Hospital Universitari Vall d'Hebron, Departamento de Medicina, Universidad Autónoma de Barcelona (UAB), Barcelona, Spain
2CIBER Enfermedades Respiratorias (CIBERES), Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Víctor Monforte
1Servicio de Neumología, Hospital Universitari Vall d'Hebron, Departamento de Medicina, Universidad Autónoma de Barcelona (UAB), Barcelona, Spain
2CIBER Enfermedades Respiratorias (CIBERES), Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Manuel López-Meseguer
1Servicio de Neumología, Hospital Universitari Vall d'Hebron, Departamento de Medicina, Universidad Autónoma de Barcelona (UAB), Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cristina Berastegui
1Servicio de Neumología, Hospital Universitari Vall d'Hebron, Departamento de Medicina, Universidad Autónoma de Barcelona (UAB), Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eva Revilla
1Servicio de Neumología, Hospital Universitari Vall d'Hebron, Departamento de Medicina, Universidad Autónoma de Barcelona (UAB), Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Eva Revilla
Christian Romero
1Servicio de Neumología, Hospital Universitari Vall d'Hebron, Departamento de Medicina, Universidad Autónoma de Barcelona (UAB), Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rosalía Laporta
4Servicio de Neumología, Hospital Universitario Puerta Hierro, Universidad Autónoma de Madrid, Madrid, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sonia Fernández-Rozas
5Servicio de Neumología, Hospital Marqués de Valdecilla, Santander, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Javier Redel-Montero
6Servicio de Neumología, Hospital Reina Sofía, Córdoba, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Amparo Solé
7Servicio de Neumología, Hospital Politécnico Universitario La Fe, Universidad de Valencia, Valencia, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mercedes de la Torre
8Servicio de Cirugía Torácica y Trasplante Pulmonar, Hospital Universitario A Coruña, A Coruña, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Luis Puente
9Servicio de Neumología, Hospital General Universitario Gregorio Marañón, Madrid, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Luis Puente
Antonio Roman
1Servicio de Neumología, Hospital Universitari Vall d'Hebron, Departamento de Medicina, Universidad Autónoma de Barcelona (UAB), Barcelona, Spain
2CIBER Enfermedades Respiratorias (CIBERES), Barcelona, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Susana Gómez-Ollés
1Servicio de Neumología, Hospital Universitari Vall d'Hebron, Departamento de Medicina, Universidad Autónoma de Barcelona (UAB), Barcelona, Spain
2CIBER Enfermedades Respiratorias (CIBERES), Barcelona, Spain
11These authors contributed equally
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Iñigo Ojanguren
1Servicio de Neumología, Hospital Universitari Vall d'Hebron, Departamento de Medicina, Universidad Autónoma de Barcelona (UAB), Barcelona, Spain
2CIBER Enfermedades Respiratorias (CIBERES), Barcelona, Spain
11These authors contributed equally
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Iñigo Ojanguren
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Figures

  • Tables
  • FIGURE 1
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 1

    Correlations between peak oxygen uptake (V′O2peak) (% predicted) and a) forced expiratory volume in 1 s (FEV1) (% predicted), b) forced vital capacity (FVC) (% predicted), c) total lung capacity (TLC) (% predicted) and d) diffusing capacity of the lungs for carbon monoxide (DLCO) (% predicted).

  • FIGURE 2
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 2

    Correlations between maximum work rate (WRmax) (watts) and a) age, b) haemoglobin (Hb) and c) forced expiratory volume in 1 s (FEV1) (L).

  • FIGURE 3
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 3

    Adjusted predicted maximal oxygen uptake (V′O2max) values (and 95% confidence interval) against diffusing capacity of the lungs for carbon monoxide (DLCO).

  • FIGURE 4
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 4

    Adjusted predicted maximum work rate (WRmax) values (and 95% confidence interval) against haemoglobin (Hb).

Tables

  • Figures
  • TABLE 1

    Clinical characteristics of lung transplant (LT) recipients

    Subjects n29
    Age years48.7±13.6
    Male sex n (%)14 (48)
    Age at the time of LT years34.7±14.0
    Years since LT14.0±3.1
    Diagnosis
     COPD3±10.3
     ILD4±13.7
     CF14±48.3
     Bronchiectasis1±3.5
     PH1±3.5
     Other6±20.7
    BMI kg·m−221.6±5.6
    FFMI kg·m−216.6±4.1
    Haemoglobin g·dL−113.3±1.5
    Arterial hypertension n (%)15 (51.7)
    Diabetes mellitus n (%)6 (20.7)
    Dyslipidaemia n (%)11 (37.9)
    Smoking history n (%)
     Never smoked21 (72.4)
     Former smoker8 (27.6)
     Packs per year29.7±23.4
    Lung function
     FVC L3.9±0.92
     FVC % predicted92.6±15.7
     FEV1 L3.1±0.7
     FEV1 % predicted97.9±14.5
      DLCO (mL·mmHg−1·min−1) median (IQR)77.1 (70–83.3)
     TLC % predicted96.1±18.3
     RV % predicted81.0±8.5
    Oral corticosteroids n (%)28 (96.6)
    Oral corticosteroids dosage mg3.9±1.6

    Data are presented as mean±sd, unless otherwise stated. Some variables have missing values: eight in FFMI, one in packs per year and one in corticosteroid dosage. ILD: interstitial lung disease; CF: cystic fibrosis; PH: pulmonary hypertension; BMI: body mass index; FFMI: fat-free mass index; FVC: forced vital capacity; FEV1: forced expiratory volume in 1 s; DLCO: diffusing capacity of the lung for carbon monoxide; IQR: interquartile range; TLC: total lung capacity; RV: residual volume.

    • TABLE 2

      Exercise capacity, physical activity and quality of life of lung transplant (LT) recipients

      Subjects n29
      V′O2 peak mL·kg−1·min−121.49±6.68
      V′O2 peak % pred75.24±15.6
      V′O2 AT %48.6±10.1
      V′CO2 peak L·min−1 median (IQR)1.68 (1.43–2.06)
      Work peak watts111.14±37.13
      V′E/V′CO2 AT32 (31–35)
      V′E peak L·min−1 median (IQR)54 (48–67.1)
      RER peak median (IQR)1.35 (1.25–1.4)
      HR peak beats·min−1141.5±21.4
      HRR peak17.5±13.6
      V′O2/HR90.5±19.4
      VR peak median (IQR)52 (48–57)
      Oximetry at V′O2 max %97.6±0.8
      Lactic acid peak mmol·L−17.35±1.89
      IPAQ METs-min·week−1 median (IQR)5497 (4007–9832)
      Euroqol 5-D1 (0.95–1)
      Euroqol >0.829±100

      Data are presented as mean±sd, unless otherwise stated.

      V′O2: oxygen uptake; V′CO2: carbon dioxide output; IQR: interquartile range; AT: aerobic threshold; V′E: minute ventilation; RER: respiratory exchange ratio; HR: heart rate; HRR: heart rate reserve; VR: ventilator reserve; IPAQ: International Physical Activity Questionnaire.

      • TABLE 3

        Results of stepwise multiple regression analysis for maximal oxygen uptake (V′O2max) and maximum workload

        V′O2max mL·kg−1·min−1Maximum workload watts
        Coefficient (95% CI)p-valueCoefficient (95% CI)p-value
        Age years−0.249 (−0.37–−0.13)<0.001−0.24 (−1.17–0.69)0.599
        Male sex5.35 (2.19–8.51)0.0024.72 (−34.75–25.30)0.748
        Haemoglobin g·dL−19.62 (2.21–17.02)0.013
        FEV1 L31.53 (8.88–54.17)0.008
        DLCO % predicted0.26 (0.15–0.36)<0.001
        Constant18.87 (16.80–20.95)<0.001
        Adjusted R20.6850.580

        FEV1: forced expiratory volume in 1 s; DLCO: diffusing capacity of the lung for carbon monoxide.

        PreviousNext
        Back to top
        Vol 7 Issue 1 Table of Contents
        ERJ Open Research: 7 (1)
        • Table of Contents
        • Index by author
        Email

        Thank you for your interest in spreading the word on European Respiratory Society .

        NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

        Enter multiple addresses on separate lines or separate them with commas.
        Near-normal aerobic capacity in long-term survivors after lung transplantation
        (Your Name) has sent you a message from European Respiratory Society
        (Your Name) thought you would like to see the European Respiratory Society web site.
        CAPTCHA
        This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
        Print
        Alerts
        Sign In to Email Alerts with your Email Address
        Citation Tools
        Near-normal aerobic capacity in long-term survivors after lung transplantation
        Berta Saez-Gimenez, Miriam Barrecheguren, Maria Antònia Ramon, Alba Gomez-Garrido, Carlos Bravo, Víctor Monforte, Manuel López-Meseguer, Cristina Berastegui, Eva Revilla, Christian Romero, Rosalía Laporta, Sonia Fernández-Rozas, Javier Redel-Montero, Amparo Solé, Mercedes de la Torre, Luis Puente, Antonio Roman, Susana Gómez-Ollés, Iñigo Ojanguren
        ERJ Open Research Jan 2021, 7 (1) 00381-2020; DOI: 10.1183/23120541.00381-2020

        Citation Manager Formats

        • BibTeX
        • Bookends
        • EasyBib
        • EndNote (tagged)
        • EndNote 8 (xml)
        • Medlars
        • Mendeley
        • Papers
        • RefWorks Tagged
        • Ref Manager
        • RIS
        • Zotero
        Share
        Near-normal aerobic capacity in long-term survivors after lung transplantation
        Berta Saez-Gimenez, Miriam Barrecheguren, Maria Antònia Ramon, Alba Gomez-Garrido, Carlos Bravo, Víctor Monforte, Manuel López-Meseguer, Cristina Berastegui, Eva Revilla, Christian Romero, Rosalía Laporta, Sonia Fernández-Rozas, Javier Redel-Montero, Amparo Solé, Mercedes de la Torre, Luis Puente, Antonio Roman, Susana Gómez-Ollés, Iñigo Ojanguren
        ERJ Open Research Jan 2021, 7 (1) 00381-2020; DOI: 10.1183/23120541.00381-2020
        del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
        Full Text (PDF)

        Jump To

        • Article
          • Abstract
          • Abstract
          • Introduction
          • Methods
          • Results
          • Discussion
          • Acknowledgement
          • Footnotes
          • References
        • Figures & Data
        • Info & Metrics
        • PDF

        Subjects

        • Lung structure and function
        • Tweet Widget
        • Facebook Like
        • Google Plus One

        More in this TOC Section

        Original articles

        • CF airway microbiota associated with NTM infection outcomes
        • Anxiety disorders and asthma among adolescents
        • Lung function improvements following inhaled IND/GLY/MF
        Show more Original articles

        Lung transplantation

        • dd-cfDNA levels are elevated in allograft rejection after LT
        • Antigravity muscles in patients undergoing LDLLT
        Show more Lung transplantation

        Related Articles

        Navigate

        • Home
        • Current issue
        • Archive

        About ERJ Open Research

        • Editorial board
        • Journal information
        • Press
        • Permissions and reprints
        • Advertising

        The European Respiratory Society

        • Society home
        • myERS
        • Privacy policy
        • Accessibility

        ERS publications

        • European Respiratory Journal
        • ERJ Open Research
        • European Respiratory Review
        • Breathe
        • ERS books online
        • ERS Bookshop

        Help

        • Feedback

        For authors

        • Instructions for authors
        • Submit a manuscript
        • ERS author centre

        For readers

        • Alerts
        • Subjects
        • RSS

        Subscriptions

        • Accessing the ERS publications

        Contact us

        European Respiratory Society
        442 Glossop Road
        Sheffield S10 2PX
        United Kingdom
        Tel: +44 114 2672860
        Email: journals@ersnet.org

        ISSN

        Online ISSN: 2312-0541

        Copyright © 2021 by the European Respiratory Society